Method for establishing early metastasis model of esophageal squamous carcinoma

A technology for esophageal squamous cell carcinoma and metastasis model, which is applied in the field of biomedicine, can solve the problems such as the inability to effectively study the rules and characteristics of esophageal squamous cell carcinoma metastasis, and less detection of lymph node metastasis, so as to facilitate the construction and increase the spread.
CN107361024AInactive Publication Date: 2017-11-21ZHENGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHENGZHOU UNIV
Publication Date
2017-11-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for establishing an early metastasis model of esophageal squamous carcinoma, and belongs to the field of biomedicine. The method can effectively study the clinical regularity and characteristics of esophageal squamous carcinoma metastasis according to the early metastasis model of esophageal squamous carcinoma. The establishing method includes the steps of screening esophageal squamous carcinoma cells to obtain the subline cells of esophageal squamous carcinoma; inoculating the subline cells of esophageal squamous carcinoma to the inside of the renal capsule of a mouse to make the subline cells of esophageal squamous carcinoma grow under the renal capsule of the mouse, and obtaining the early metastasis model of esophageal squamous carcinoma. The method for establishing the early metastasis model of esophageal squamous carcinoma is used for studying the clinical regularity and characteristics of esophageal squamous carcinoma metastasis.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and in particular relates to a method for establishing an early metastasis model of esophageal squamous cell carcinoma. Background technique

[0002] Esophageal squamous cell carcinoma metastasis model is an animal model of esophageal cancer with simple preparation method, fast tumor formation, high tumor formation rate, and low cost. It is widely used in the study of invasion and metastasis mechanisms of esophageal squamous cell carcinoma.

[0003] In the prior art, when preparing the metastasis model of esophageal squamous cell carcinoma, the method of injecting esophageal squamous cell carcinoma cells into the tail vein or intraperitoneal cavity is used to inoculate the esophageal squamous cell carcinoma cells into the mice, and the esophageal squamous cell carcinoma cells mostly produce lung, Liver and peritoneal metastasis, and lymph node metastasis is rarely found, and clinical metastasis is most...

Claims

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