Target feasible region extracting method of X-ray luminescence tomography

Abstract

The invention belongs to the technical field of molecular imaging, and discloses a target feasible region extracting method of X-ray luminescence tomography. The method is based on the theory of optical transmission and a finite element method and adopts such prior information as optical property parameters, anatomical structures and the like; N groups of different grids are designed and are subjected to global reconstruction, and statistical analysis is conducted on the basis of reconstruction results of the N pieces of grids; and a group of new feasible regions are extracted in accordance with a region overlapping degree, and the feasible regions, as reconstruction regions, are subjected to target reconstruction once again. The method, which diminishes the reconstruction regions, can reduce the ill-posed nature of a problem and effectively improve a reconstruction result of the X-ray luminescence tomography; and the method has an important application value in such fields as molecular imaging, reconstruction algorithm and the like. With the application of the method provided by the invention, the ill-posed nature of the optical imaging inverse problem is relieved and reconstruction quality is effectively improved; and the method is also applicable to bioluminescence tomography (BLT), fluorescence molecular tomography (FML) and other optical molecular imaging fields.

Description

technical field [0001] The invention belongs to the technical field of molecular imaging, in particular to a method for extracting a target feasible area of ​​X-ray luminescence tomography. Background technique [0002] X-Ray Luminescence Computed Tomography (XLCT for short) is a new type of molecular imaging technology that can simultaneously perform functional imaging and molecular imaging. Specifically, with the help of modern optical molecular probe synthesis technology, a molecular probe synthesized by nano-luminescent particles with luminescent properties is used to construct a new type of optical molecular imaging system combined with Micro-CT; X-rays are used to irradiate nano-luminescent materials in vivo to excite It generates near-infrared light and collects it through a high-sensitivity CCD (Charge coupled device, CCD) camera, combined with reconstruction methods to invert the three-dimensional distribution of nano-luminescent targets. Compared with other optica...

AI Technical Summary

Problems solved by technology

[0003] To sum up, the problems existing in the existing technology are: in the reconstruction of X-ray luminescence tomography imaging, the optical data collected by the optical detector is only the surface data of the imaging target, the number is limited, and the number of internal points in the solution area is very large

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