Application of spermine as marker in preparation of product for diagnosing pulmonary arterial hypertension and medical apparatus thereof
A pulmonary arterial hypertension and marker technology, applied in the field of biomedicine, can solve problems such as the inability to effectively carry out right heart catheterization, and achieve the effects of assessing severity, reducing technical difficulty, and reducing risk
Active Publication Date: 2017-12-05
FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE +1
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Problems solved by technology
Right heart catheterization is an invasive procedure with certain operational risks.
At the same time, due to technical and equipment reasons, some primary hospitals cannot effectively carry out right heart catheterization
Method used
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Embodiment
[0051] In this example, healthy people were taken as controls, and patients with pulmonary arterial hypertension were taken as research objects to verify the close relationship between plasma spermine levels and pulmonary arterial hypertension.
[0052] 1. Subjects:
[0053] Subject group: The subjects were from patients diagnosed and treated by Fuwai Hospital of Chinese Academy of Medical Sciences and healthy people recruited.
[0054] Inclusion and exclusion criteria for patients with pulmonary arterial hypertension: at rest at sea level, right heart catheterization detects mean pulmonary artery pressure ≥ 25 mm Hg), pulmonary arteriole wedge pressure ≤ 15 mm Hg; congenital heart disease, systemic lung shunt, drug-induced, viral Infection, pulmonary embolism, autoimmune disease and other factors, and no comorbid symptoms such as tumor, infection, abnormal liver and kidney function.
[0055] A total of 30 cases in the pulmonary hypertension group and 30 cases in the healthy ...
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The invention provides an application of spermine as a marker in preparation of a product for diagnosing pulmonary arterial hypertension and a medical apparatus thereof, which belong to the technical field of biomedicine. The research result finds that spermine and the pulmonary arterial hypertension are closely related, the spermine is firstly taken as the marker, and can be used for preparing the relative products for discriminating, diagnosing, and screening the pulmonary arterial hypertension. The compound is taken as the marker for predicting the pulmonary arterial hypertension, and accurately and sensitively predicts and discriminates the disease at an early stage and the malignant degree of the pulmonary arterial hypertension, so that the invasive operation risk of right heart catheterization employed during the pulmonary arterial hypertension diagnosis process in the prior art is reduced, and the technical difficulty of the pulmonary arterial hypertension is reduced, and the invention provides the brand new objective index for discriminating, diagnosing, screening the pulmonary arterial hypertension or evaluating curative effect of the medicines.
Description
technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of spermine as a marker in the preparation of diagnostic products for pulmonary arterial hypertension and medical equipment. Background technique [0002] Pulmonary hypertension is a malignant cardiovascular disease in which pulmonary artery resistance continues to increase due to pulmonary vascular remodeling and progressive stenosis. It also refers to a hemodynamic and pathophysiological state in which pulmonary artery pressure increases beyond a certain limit. Generally, at rest at sea level, the mean pulmonary artery pressure detected by right heart catheterization is ≥25 mm Hg as the diagnostic standard. Pulmonary hypertension has strong heterogeneity, unknown etiology, hidden symptoms, and poor prognosis. It can be called a "cancer" of the cardiovascular system. Pulmonary hypertension is characterized hemodynamically by a resting mean pulmonary artery p...
Claims
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Login to View More IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 荆志成何阳阳王晓建颜艺张宏达赵隽涵吕子超连天宇叶珏韩志岩
Owner FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE