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A carbon nanotube-reinforced injectable antibacterial conductive nanocomposite hemostatic crystal gel dressing and its preparation method and application

A technology of carbon nanotubes and conductive nanometers, which is applied in the field of injectable antibacterial conductive nanocomposite hemostatic gel dressing and its preparation, can solve the problems of loss of effect and achieve the effect of promoting healing and promoting the formation of blood vessels

Active Publication Date: 2020-05-19
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the aforementioned materials are often ineffective in applications that stop bleeding from irregular deep wounds from small-bore weapons or explosive devices

Method used

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  • A carbon nanotube-reinforced injectable antibacterial conductive nanocomposite hemostatic crystal gel dressing and its preparation method and application
  • A carbon nanotube-reinforced injectable antibacterial conductive nanocomposite hemostatic crystal gel dressing and its preparation method and application
  • A carbon nanotube-reinforced injectable antibacterial conductive nanocomposite hemostatic crystal gel dressing and its preparation method and application

Examples

Experimental program
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preparation example Construction

[0046] The preparation method of the present invention comprises the following steps:

[0047] 1) Preparation of QCSG (glycidyl methacrylate functionalized quaternized chitosan, glycidyl methacrylate functionalized quaternized chitosan) polymer: 0.8-1.2 g of chitosan was resuspended in 36 mL of deionized water, and then 180 μL of Glacial acetic acid was added dropwise with stirring, then it was heated at 50-60° C. and stirred for 30-60 min. Subsequently, 773 μL to 2319 μL of GTMAC (glycidyltrimethylammonium chloride, glycidyltrimethylammonium chloride) was added dropwise to the solution of chitosan. Subsequently, stirring was continued at 50-60° C. and the reaction was carried out for 15-18 h. After the reaction, 382.16-764.32 μL of GMA (glycidyl methacrylate, glycidyl methacrylate) was added to the above reaction solution respectively, and the reaction was continued at 50-60° C. for 15-18 h in the dark. The preferred reaction is to use 1.0 g of chitosan, heat the reaction a...

Embodiment 1

[0054] 1) One-pot preparation of QCSG polymer: 1 g of chitosan was resuspended in 36 mL of deionized water, and then 180 μL of glacial acetic acid was added dropwise with stirring, and then it was heated at 55° C. and stirred for 30 min. 2319 μL of GTMAC was then added dropwise to the solution of chitosan. Then continued stirring at 55°C for 15h. After the reaction, 382.16 μL of GMA was added dropwise to the reaction solution, and the reaction was continued at 55° C. in the dark for 15 h. After the reaction, the reaction solution was centrifuged at 7000 rpm for 20 min, and then the supernatant was precipitated in pre-cooled acetone to obtain the crude product of QCSG. The crude QCSG product was then dissolved in deionized water and dialyzed for three days using a dialysis bag with a molecular cut-off of 3500 DA. After dialysis, the purified QCSG product was obtained by freeze-drying.

[0055] 2) Preparation of QCSG / CNT0 gel: QCSG polymer was prepared into a 5 wt% solution i...

Embodiment 2

[0057] 1) One-pot preparation of QCSG polymer: 1 g of chitosan was resuspended in 36 mL of deionized water, and then 180 μL of glacial acetic acid was added dropwise with stirring, and then it was heated at 55° C. and stirred for 30 min. 2319 μL of GTMAC was then added dropwise to the solution of chitosan. Then continued stirring at 55°C for 15h. After the reaction, 382.16 μL of GMA was added dropwise to the reaction solution, and the reaction was continued at 55° C. in the dark for 15 h. After the reaction, the reaction solution was centrifuged at 7000 rpm for 20 min, and then the supernatant was precipitated in pre-cooled acetone to obtain the crude product of QCSG. The crude QCSG product was then dissolved in deionized water and dialyzed for three days using a dialysis bag with a molecular cut-off of 3500 DA. After dialysis, the purified QCSG product was obtained by freeze-drying.

[0058] 2) Preparation of PF127-DA polymer: 2.54 g of PF127 and 0.061 g of triethylamine w...

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Abstract

The invention relates to a carbon nanotube (CNT) reinforced injectable antibacterial conductive nano composite haemostatic cryogel dressing as well as a preparation method and application thereof. The preparation method comprises the following steps of firstly adding glycidyl methacrylate functionalized quaternized chitosan (QCSG) into a solvent, and preparing into a QCSG solution; adding a CNT and PF127 into a solvent, and preparing into CNT dispersion liquid; mixing the QCSG solution and the CNT dispersion liquid, meanwhile, adding an initiator solution and a TEMED (Tetramethylethylenediamine) solution, and uniformly mixing, so that mixed liquid is obtained; placing the mixed liquid at subzero 18 to subzero 20 DEG C, and carrying out a reaction for 18h to 24h, so that a cross-linked cryogel network in a frozen state is obtained; putting the cross-linked cryogel network in the frozen state into a solvent, and thawing, so that the CNT reinforced injectable antibacterial conductive nano composite haemostatic cryogel dressing is obtained. The cryogel dressing provided by the invention has high elasticity and ultrafast shape restoration capacity, can be used for quickly absorbing blood, and has photothermal antibacterial performance and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a carbon nanotube-reinforced injectable antibacterial conductive nano-composite hemostatic crystal glue dressing and a preparation method and application thereof. Background technique [0002] Worldwide, uncontrolled bleeding is responsible for more than 30% of trauma deaths, and more than half of these deaths occur before emergency care is reached. Therefore, the development of hemostatic materials for efficient and rapid control of bleeding is crucial for trauma emergency care. However, currently commonly used hemostatic materials, such as acrylic resin-based adhesives, glutaraldehyde-crosslinked albumin, etc., exhibit toxicity and potential mutagenicity. In addition, the widely used zeolite-based QuickClot hemostatic agent can generate heat and cause tissue burns, and studies have also demonstrated that QuickClot or HemCon have no significant survival...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61L26/00
CPCA61L26/0004A61L26/0019A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L26/0085A61L2300/216A61L2300/41A61L2300/602A61L2400/04A61L2400/06A61L2400/16C08L5/08C08L71/02
Inventor 郭保林赵鑫屈锦
Owner XI AN JIAOTONG UNIV
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