Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Carbon nanotube (CNT) reinforced injectable antibacterial conductive nano composite haemostatic cryogel dressing as well as preparation method and application thereof

A carbon nanotube and conductive nanotechnology, applied in the field of injectable antibacterial conductive nanocomposite hemostatic crystal glue dressing and its preparation, can solve problems such as loss of effect, and achieve the effects of promoting healing and promoting the formation of vascularization

Active Publication Date: 2017-12-08
XI AN JIAOTONG UNIV
View PDF4 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the aforementioned materials are often ineffective in applications that stop bleeding from irregular deep wounds from small-bore weapons or explosive devices

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Carbon nanotube (CNT) reinforced injectable antibacterial conductive nano composite haemostatic cryogel dressing as well as preparation method and application thereof
  • Carbon nanotube (CNT) reinforced injectable antibacterial conductive nano composite haemostatic cryogel dressing as well as preparation method and application thereof
  • Carbon nanotube (CNT) reinforced injectable antibacterial conductive nano composite haemostatic cryogel dressing as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0046] The preparation method of the present invention comprises the following steps:

[0047] 1) Preparation of QCSG (glycidyl methacrylate functionalized quaternized chitosan, glycidyl methacrylate functionalized quaternized chitosan) polymer: 0.8-1.2 g of chitosan was resuspended in 36 mL of deionized water, and then 180 μL of Glacial acetic acid was added dropwise while stirring, and then heated at 50-60°C and stirred for 30-60 minutes. Subsequently, 773 μL˜2319 μL of GTMAC (glycidyltrimethylammonium chloride, glycidyltrimethylammonium chloride) was added dropwise to the chitosan solution. Then keep stirring at 50-60°C and react for 15-18 hours. After the reaction, 382.16-764.32 μL of GMA (glycidyl methacrylate, glycidyl methacrylate) was added to the above reaction solution respectively, and then the reaction was continued at 50-60° C. in the dark for 15-18 hours. A preferred reaction is to use 1.0 g of chitosan, heat the reaction at 55°C, 2319 μL of GTMAC, and 382.16 μ...

Embodiment 1

[0054] 1) One-pot preparation of QCSG polymer: 1 g of chitosan was resuspended in 36 mL of deionized water, then 180 μL of glacial acetic acid was added dropwise with stirring, and then heated at 55°C and stirred for 30 min. Then 2319 μL of GTMAC was added dropwise to the chitosan solution. Subsequently, stirring was continued at 55° C. for 15 h. After the reaction was completed, 382.16 μL of GMA was added dropwise to the reaction solution, and then the reaction was continued for 15 h at 55° C. in the dark. After the reaction, the reaction solution was centrifuged at 7000 rpm for 20 min, and then the supernatant was precipitated in pre-cooled acetone to obtain a crude product of QCSG. The crude QCSG product was subsequently dissolved in deionized water and dialyzed for three days using a dialysis bag with a molecular cutoff of 3500 DA. After dialysis, the purified QCSG product was obtained by lyophilization.

[0055] 2) Preparation of QCSG / CNT0 gel: the QCSG polymer was pre...

Embodiment 2

[0057] 1) One-pot preparation of QCSG polymer: 1 g of chitosan was resuspended in 36 mL of deionized water, then 180 μL of glacial acetic acid was added dropwise with stirring, and then heated at 55°C and stirred for 30 min. Then 2319 μL of GTMAC was added dropwise to the chitosan solution. Subsequently, stirring was continued at 55° C. for 15 h. After the reaction was completed, 382.16 μL of GMA was added dropwise to the reaction solution, and then the reaction was continued for 15 h at 55° C. in the dark. After the reaction, the reaction solution was centrifuged at 7000 rpm for 20 min, and then the supernatant was precipitated in pre-cooled acetone to obtain a crude product of QCSG. The crude QCSG product was subsequently dissolved in deionized water and dialyzed for three days using a dialysis bag with a molecular cutoff of 3500 DA. After dialysis, the purified QCSG product was obtained by lyophilization.

[0058] 2) Preparation of PF127-DA polymer: Dissolve 2.54g of PF1...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a carbon nanotube (CNT) reinforced injectable antibacterial conductive nano composite haemostatic cryogel dressing as well as a preparation method and application thereof. The preparation method comprises the following steps of firstly adding glycidyl methacrylate functionalized quaternized chitosan (QCSG) into a solvent, and preparing into a QCSG solution; adding a CNT and PF127 into a solvent, and preparing into CNT dispersion liquid; mixing the QCSG solution and the CNT dispersion liquid, meanwhile, adding an initiator solution and a TEMED (Tetramethylethylenediamine) solution, and uniformly mixing, so that mixed liquid is obtained; placing the mixed liquid at subzero 18 to subzero 20 DEG C, and carrying out a reaction for 18h to 24h, so that a cross-linked cryogel network in a frozen state is obtained; putting the cross-linked cryogel network in the frozen state into a solvent, and thawing, so that the CNT reinforced injectable antibacterial conductive nano composite haemostatic cryogel dressing is obtained. The cryogel dressing provided by the invention has high elasticity and ultrafast shape restoration capacity, can be used for quickly absorbing blood, and has photothermal antibacterial performance and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a carbon nanotube-reinforced injectable antibacterial and conductive nanocomposite hemostatic gel dressing, a preparation method and application thereof. Background technique [0002] Worldwide, uncontrolled bleeding is responsible for more than 30% of trauma deaths, and more than half of these deaths occur before emergency care can be reached. Therefore, the development of hemostatic materials for efficient and rapid control of bleeding is essential for trauma first aid. However, currently commonly used hemostatic materials, such as acrylic resin-based adhesives, glutaraldehyde-crosslinked albumin, etc., exhibit toxicity and potential mutagenicity. In addition, the widely used zeolite-based QuickClot hemostatic agent can generate heat and cause tissue burns. Studies have also proved that QuickClot or HemCon has no significant advantage in survival rate ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0019A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L26/0085A61L2300/216A61L2300/41A61L2300/602A61L2400/04A61L2400/06A61L2400/16C08L5/08C08L71/02
Inventor 郭保林赵鑫屈锦
Owner XI AN JIAOTONG UNIV
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com