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Application of loganin in preparation of medicine and health product for treating or alleviating ache

A pain-relieving and loganin technology, applied in the field of medicine, can solve problems such as no research, no literature and relevant patents showing loganin, etc., to improve pain threshold, prolong pain reaction time, and reduce writhing. effect of times

Inactive Publication Date: 2017-12-19
CHINA JAPAN FRIENDSHIP HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pharmacological effects and clinical application of loganin in relieving or treating pain symptoms have not been studied so far.
[0005] At present, the Chinese invention patents related to loganin can only be seen in the preparation method (CN104447910A), the content determination method (CN103808811A), the drug for treating diabetes (CN103110651A), the application in the drug for improving sleep (CN105902536A) and the prevention and treatment of depression and anxiety. In terms of drugs for mental disorders such as schizophrenia (CN106176789A), there is no literature or related patents showing that loganin has analgesic activity and can be used for drug treatment of pain

Method used

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  • Application of loganin in preparation of medicine and health product for treating or alleviating ache
  • Application of loganin in preparation of medicine and health product for treating or alleviating ache
  • Application of loganin in preparation of medicine and health product for treating or alleviating ache

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Comparison of pharmacodynamic characteristics of loganin's analgesic effect on mouse acetic acid writhing model.

[0031] The purpose of this example is to induce peritonitis in mice by intraperitoneal injection of glacial acetic acid to produce pain manifestations, to simulate a chronic persistent pathological visceral pain experimental model of abdominal inflammation, and to observe the analgesic effect of loganin on the mouse model.

[0032] 20-24g male ICR mice were used as experimental animals, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (animal certificate number: SCXK (Beijing) 2012-0001). The breeding temperature was 23±2°C, the lighting time was 12 mice / day (lights were turned on from 7:00 to 19:00), and the experiment was carried out after one week of feeding. The mice were randomly divided into 8 groups according to body weight, 10 in each group, respectively blank control group (distilled water), aspirin group (10...

Embodiment 2

[0040] Example 2: Time-effect relationship of loganin on analgesic effect of mouse acetic acid writhing model

[0041] Screen experimental animals according to the method described in Example 1, be divided into 5 groups, every group of 10, before acetic acid treatment different pretreatment time (10,30,60,90 minutes) tail vein injection loganin (50mg / kg), intraperitoneally inject 0.7% glacial acetic acid (0.2ml / 20g), observe the mouse writhing number of times in 20 minutes. One-way analysis of variance was used for statistics, and the results were as follows: figure 1 shown.

[0042] Experimental results show that after loganin 50mg / kg is administered, analgesic effect is produced in 10 minutes, and the number of times of mouse acetic acid writhing is significantly reduced. 10-60 minutes, P<0.05), when more than 90 minutes after administration, the effect disappeared. After long-term administration, the drug was suddenly withdrawn, and no abnormal drug withdrawal reaction ...

Embodiment 3

[0043] Example 3: Comparison of pharmacodynamic characteristics of loganin's analgesic effect on mouse hot plate model.

[0044]This example aims to observe the analgesic effect of loganin on mice by the hot plate method. In the hot plate method, because the testes of male mice are extremely sensitive to heat, female mice are selected as the research objects.

[0045] 20-24g female ICR mice were used as experimental animals, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (animal certificate number: SCXK (Beijing) 2012-0001). The breeding temperature was 23±2°C, the lighting time was 12 hours / day (lights were turned on from 7:00 to 19:00), and the experiment was carried out after one week of feeding. During the experiment, the female mice were placed on an intelligent constant temperature hot plate apparatus (55±0.5)°C, and the latency period of the mice licking the rear paw was used as the pain threshold index. Before the experiment, those whose...

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Abstract

The invention belongs to the field of a compound medicine, relates to a novel purpose of a loganin medicine, and especially relates to an application of loganin in preparation of the medicine and a health product for treating or alleviating ache. The single acute administration of a loganin medicinal preparation can effectively reduce the body torsion frequency of mice after acetic acid injection, the mice pain threshold in a hot plate teat is increased, and the mice ache reaction time is prolonged. Long-term chronic administration has pain ease effect, and generation of tolerance and addiction cannot be observed. The loganin can be used for medical treatment on various clinical aches, especially inflammation ache, or can be used for preparing the health products capable of alleviating the ache, and the dosage forms comprise tablets, capsules, particulate agents, electuary, oral liquid, dripping pills, pellets or injection. The tablets are prepared by loganin, hydroxypropyl methyl cellulose, a hydrophilic accessory and a lubricant, wherein the weight ratio of loganin to hydroxypropyl methyl cellulose is 1:2-5.

Description

technical field [0001] The invention belongs to the field of medicaments, and relates to a new drug application of loganin, in particular to the application of loganin in preparing a drug for treating pain or a health care product for relieving pain. technical background [0002] Pain is a complex physiological and psychological activity. It is a pathophysiological process accompanied by emotional responses when the body receives noxious stimuli from the internal and external environment. It is one of the most common clinical symptoms. According to the nerve part, it can be divided into central neuropathic pain, peripheral neuropathic pain and autonomic neuropathic pain. The impact of pain on the body is multifaceted from local to overall, and severe cases can lead to physiological dysfunction and even painful shock. [0003] At present, the drugs used clinically for pain treatment mainly include the following categories: opioid analgesics, centrally acting non-opioid analg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/04A23L33/105
CPCA61K31/7048A23L33/105A23V2002/00A23V2200/30A23V2250/21
Inventor 张维库续洁琨赫军阎雨乔灏祎韩炎
Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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