A system for classifying atherosclerotic plaque

Abstract

The invention discloses a system for classifying atherosclerotic plaques, which includes: an angiography device, used to obtain vascular contrast-enhanced ultrasound images; a basic parameter acquisition device, used to analyze the vascular contrast-enhanced ultrasound images, To obtain the maximum plaque area A, intraluminal-time-intensity curve and intra-plaque-time-intensity curve, and extract intraluminal contrast agent peak time TTP1, peak intensity IMAX1, and curve from the intraluminal-time-intensity curve The area under the area AUC1, and from the intra-plaque-time-intensity curve extract the intra-plaque contrast agent peak time TTP2, peak intensity IMAX2 and area under the curve AUC2; the plaque quantitative parameter calculation device is used to obtain the enhanced intensity IMAX, Maximum enhanced density DMAX, relative peak time △TTP, area under the curve △AUC and relative average transit time △mTT; classification result output device: used to classify atherosclerotic plaques according to the above plaque quantitative parameters.

Description

technical field [0001] The invention relates to the medical field of atherosclerosis, in particular to a system for classifying atherosclerotic plaques. Background technique [0002] The main lesions of atherosclerosis are characterized by subintimal lipid deposition in some parts of the artery, accompanied by the proliferation of smooth muscle cells and fibrous matrix components, and gradually develop into atherosclerotic plaques. It is a lesion characterized by patchy subintimal thickening (atheroma) of medium and large arteries that can reduce or block blood flow. The arterial wall at the plaque site thickens and hardens, and the tissue inside the plaque is necrotic and combines with deposited lipids to form atherosclerosis, which is called atherosclerosis. [0003] Intra-plaque neovascularization is an important factor leading to plaque instability, and contrast-enhanced angiography can quantitatively evaluate the number of intra-plaque neovascularization. At present, ...

AI Technical Summary

Problems solved by technology

At present, the indicators commonly used abroad for evaluating plaque stability by ultrasound software are generally peak intensity (PI), time to peak (TTP), and mean transit time (mTT), but they are susceptible to individual differences in patients, different injection doses of contrast agents, Due to the influence of factors such as vascular variation and plaque size, the error between the evaluation results and the actual situation is large, and the clinical application is limited.

Recently, it has been found that the maximum enhancement density (DMAX), relative time to peak (△TTP), relative area under the curve (△ACU), relative mean transit time (△mTT), and enhancement intensity (IMAX) are indicators for accurately evaluating neovascularization. However, the above indicators cannot be directly measured under the current technical level, and a large number of manual measurements and calculations are required in the later stage. In addition, there is no unified and clear reference range for plaque quantitative analysis, resulting in the inability to obtain plaque properties. quantitative report

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