Method for measuring thickness of coating layer of degradable drug eluting stent

A technology of coating thickness and measurement method, which is applied in the field of measurement of the coating thickness of degradable drug-coated stents, can solve the problem of small volume, thin coating integrity is easily damaged, and it is difficult to ensure polymer coating on the surface of the stent. Layer integrity and other issues, to avoid the effect of mutual dissolution

Active Publication Date: 2018-01-19
深圳市领先医疗服务有限公司
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  • Abstract
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Problems solved by technology

Another commonly used measurement method is the cold mounting microscopic analysis method, which uses the cold mounting solution to directly cure the stent and measure the coating thickness. However, due to the small size, thin coating and complete coating of the degradable drug It is difficult to accurately measure the thickness of metal coatings and polymer coatings at the same time by conventional cold mosaic microscopic analysis
When the two coatings exist at the same time, the polymer coating is easily soluble in the cold mounting solution because of similar miscibility, so it is difficult to ensure the integrity of the polymer coating on the surface of the stent by conventional cold mounting microscopic analysis

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  • Method for measuring thickness of coating layer of degradable drug eluting stent
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  • Method for measuring thickness of coating layer of degradable drug eluting stent

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Embodiment Construction

[0027] In order to better understand the technical solutions and beneficial effects of the present invention, the present invention will be described in detail below in conjunction with specific embodiments. It should be noted that any skilled person who implements the present invention should be a person skilled in the art, and should be familiar with common knowledge and routine experimental operations in this field. The solidification solution referred to in the present invention is a mixed solution commonly used for mounting samples in the cold mounting method.

[0028] Such as figure 1 and figure 2 As shown, the degradable drug-coated stent 1 to be measured in the present invention is made of a hollow tube body through laser cutting, the tube wall is hollowed out, and the inner and outer surfaces of the tube wall are coated with a coating, as figure 2 As shown, on the cross-section of the stent 1 perpendicular to the axis, a plurality of circumferential stent rod sect...

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Abstract

The invention discloses a method for measuring the thickness of a coating layer of a degradable drug eluting stent. Through the coating of a precious metal protection layer on the surface of a stent polymer coating, the contact of the polymer coating with solution for curing is prevented during the subsequent cold inset curing processing of a sample, thereby preventing the direct contact and mutual dissolving of the polymer coating and the solution from damaging the polymer coating and causing a problem that the subsequent measurement cannot be carried out. The method provided by the inventioncan maintain the integrity of the polymer coating after the cold inset curing processing, and achieves the accurate measurement of the thickness of the polymer coating and the metal coating under a scanning electron microscope.

Description

technical field [0001] The invention relates to the field of absorbable vascular stents, in particular to a method for measuring the coating thickness of a degradable drug-coated stent. Background technique [0002] In recent years, percutaneous implantation of degradable vascular stents has become a research hotspot in the treatment of coronary atherosclerosis. Degradable vascular stents are made of biodegradable or absorbable materials, which can support blood vessels and treat specific diseases , and eventually degrade and disappear in the body, avoiding the long-term foreign body impact of permanent metal stent implantation on the human body. [0003] The degradable drug-coated stent is mainly composed of a stent, a polymer carrier and a drug part, and the polymer carrier and drug are also collectively referred to as a polymer coating. The stents are usually metal stents, ceramic stents and polymer material stents. Metal stents are favored because of their superior mech...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01B21/08G01Q30/20G01Q30/02
Inventor 胡君源祁凤君
Owner 深圳市领先医疗服务有限公司
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