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Microreaction system and method for synthesis of anisole and derivatives thereof

A synthesis method and micro-reaction technology, which is applied in the field of micro-reaction systems for synthesizing anisole and its derivatives, can solve problems such as energy consumption and low production efficiency, and achieve the goals of increasing utilization, increasing production efficiency, and reducing energy consumption Effect

Active Publication Date: 2018-01-26
TSINGHUA UNIV +1
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Problems solved by technology

The production efficiency of the above-mentioned traditional methods is low, and the refrigeration process also causes a large amount of energy consumption

Method used

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  • Microreaction system and method for synthesis of anisole and derivatives thereof
  • Microreaction system and method for synthesis of anisole and derivatives thereof
  • Microreaction system and method for synthesis of anisole and derivatives thereof

Examples

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Embodiment 1

[0026] Embodiment 1: the synthesis of anisole

[0027] The micro-reaction system in this embodiment consists of a micro-sieve mixing reactor, a tubular heat exchanger and a clarification tank in series. The synthetic steps of anisole are as follows:

[0028] (1) Use a metering pump to transport the reaction raw materials sodium phenate and dimethyl sulfate to the micro-sieve mixing reactor, monitor the temperature of the key position of the reaction (reaction raw material and the outlet of the heat exchanger) in real time, and mix the raw materials to initiate the reaction to form a high-temperature reaction Liquid C;

[0029] (2) After the high-temperature reaction liquid C flows out from the micro-sieve mixing reactor, the temperature of the product is controlled through a tubular heat exchanger to form a low-temperature reaction liquid D;

[0030] (3) After the low-temperature reaction solution D flows out from the heat exchanger, it is separated through a phase separator...

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Abstract

Belonging to technical field of chemical product synthesis, the invention discloses a microreaction system and method for synthesis of anisole and derivatives thereof. The system is formed by connection of a microreactor, a heat exchanger and a phase separator in series successively. The synthesis method includes: mixing a sodium salt water solution of phenol or its derivatives and dimethyl sulfate in the microreactor and initiating reaction, controlling the product temperature by the heat exchanger, and performing separation by the phase separator to obtain anisole and derivatives thereof. The system and method provided by the invention can realize low-energy consumption and continuous production of anisole and its derivatives, improve the utilization rate of dimethyl sulfate, and can achieve a sodium phenolate conversion rate of 98% or more under the condition of a dimethyl sulfate / sodium phenolate mole ratio of slightly larger than 1.0, and the product purity reaches 99% or more.

Description

technical field [0001] The invention belongs to the technical field of chemical product synthesis, and in particular relates to a micro-reaction system and method for synthesizing anisole and its derivatives. Background technique [0002] Anisole, methyl anisole and other substances are important dyes and pharmaceutical intermediates, which are often used in the process of organic synthesis. These substances are mainly obtained through the methylation of phenolic hydroxyl groups. Taking anisole as an example, the traditional synthesis method is to mix phenol and dimethyl sulfate at a reaction temperature of about 5°C, and then gradually add NaOH aqueous solution to the mixture at this low temperature. The reaction occurs first to form sodium phenate, which then reacts with dimethyl sulfate to form anisole. The basic principle of the reaction is shown in the following formula: [0003] [0004] Wherein R is H or CnHm (n=1, 2, 3...; m=2n-1) and the like. [0005] Since d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C41/16C07C43/205C07C41/38
Inventor 王凯骆广生张鹏王德强卢凤阳
Owner TSINGHUA UNIV
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