Nitrendipine medicine composition for treating hypertensive heart failure

A technology of nitrendipine and its composition, which is applied in the field of compound western medicine, can solve the problems of not preventing or treating hypertension complications, and achieve the effects of preventing various complications, reducing adverse reactions, and preventing heart failure

Inactive Publication Date: 2018-02-02
NANJING ZHENGLIANG MEDICAL TECH
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the combined application of nitrendipine and sodium alginate in the prior art, e

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nitrendipine medicine composition for treating hypertensive heart failure
  • Nitrendipine medicine composition for treating hypertensive heart failure
  • Nitrendipine medicine composition for treating hypertensive heart failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 Preparation of nitrendipine / sodium alginate diester compound tablet

[0022] Prescription composition:

[0023]

[0024] Preparation Process:

[0025] Weigh nitrendipine and sodium alginate diester according to the prescription, use microcrystalline cellulose and starch as fillers, cross-linked sodium carboxymethyl cellulose and cross-linked povidone as disintegrants, 5% PVP 60% Ethanol solution is used as binder, magnesium stearate is used as lubricant, and it is granulated by fluidized bed in one step, and then compressed into tablets.

Embodiment 2

[0026] Embodiment 2 Preparation of nitrendipine / sodium alginate diester compound tablet

[0027] Prescription composition:

[0028]

[0029] Preparation Process:

[0030] Weigh nitrendipine and sodium alginate diester according to the prescription, use microcrystalline cellulose and starch as fillers, cross-linked sodium carboxymethyl cellulose and cross-linked povidone as disintegrants, 5% PVP 60% Ethanol solution is used as binder, magnesium stearate is used as lubricant, and it is granulated by fluidized bed in one step, and then compressed into tablets.

Embodiment 3

[0031] Example 3 Study on the curative effect of combined application of nitrendipine / sodium alginate on chronic heart failure

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a nitrendipine-containing medicine composition. Active ingredients of the nitrendipine-containing medicine composition comprise nitrendipine and polysaccharide sulfate, preferably, the weight ratio of nitrendipine to polysaccharide sulfate is 1 to (5 to 10). According to the medicine composition disclosed by the invention, all complicating diseases of hypertensive patientscan be effectively cooperatively prevented, a long-term survival rate of patients is increased, and meanwhile, the nitrendipine-containing medicine composition has a good prevention effect on heart failure for the hypertensive patients.

Description

technical field [0001] The invention relates to a western medicine compound, in particular to a nitrendipine pharmaceutical composition for treating hypertension and heart failure, which contains a small dose of nitrendipine. Background technique [0002] Heart failure is a common complication of hypertension. Epidemiological studies have shown that 40%-50% of heart failure is caused by hypertension. The higher your blood pressure, without treatment, the more likely you are to develop heart failure. Someone followed up 5314 hypertensive patients for 14.1 years, and 392 cases developed heart failure. Hypertension has been considered as the main risk of left ventricular hypertrophy and myocardial infarction, and left ventricular hypertrophy and myocardial infarction can cause cardiac insufficiency. Therefore, Hypertension plays an important role in the course of heart failure. Nitrendipine, used for coronary heart disease and hypertension, especially in patients with these t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/737A61K31/4422A61P9/12A61P9/04
CPCA61K31/737A61K31/4422A61K2300/00
Inventor 赵明亮
Owner NANJING ZHENGLIANG MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap