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Nitrendipine medicine composition for treating hypertensive heart failure

A technology of nitrendipine and its composition, which is applied in the field of compound western medicine, can solve the problems of not preventing or treating hypertension complications, and achieve the effects of preventing various complications, reducing adverse reactions, and preventing heart failure

Inactive Publication Date: 2018-02-02
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the combined application of nitrendipine and sodium alginate in the prior art, especially no report on the prevention or treatment of hypertensive complications after the combined application of the two

Method used

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  • Nitrendipine medicine composition for treating hypertensive heart failure
  • Nitrendipine medicine composition for treating hypertensive heart failure
  • Nitrendipine medicine composition for treating hypertensive heart failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 Preparation of nitrendipine / sodium alginate diester compound tablet

[0022] Prescription composition:

[0023]

[0024] Preparation Process:

[0025] Weigh nitrendipine and sodium alginate diester according to the prescription, use microcrystalline cellulose and starch as fillers, cross-linked sodium carboxymethyl cellulose and cross-linked povidone as disintegrants, 5% PVP 60% Ethanol solution is used as binder, magnesium stearate is used as lubricant, and it is granulated by fluidized bed in one step, and then compressed into tablets.

Embodiment 2

[0026] Embodiment 2 Preparation of nitrendipine / sodium alginate diester compound tablet

[0027] Prescription composition:

[0028]

[0029] Preparation Process:

[0030] Weigh nitrendipine and sodium alginate diester according to the prescription, use microcrystalline cellulose and starch as fillers, cross-linked sodium carboxymethyl cellulose and cross-linked povidone as disintegrants, 5% PVP 60% Ethanol solution is used as binder, magnesium stearate is used as lubricant, and it is granulated by fluidized bed in one step, and then compressed into tablets.

Embodiment 3

[0031] Example 3 Study on the curative effect of combined application of nitrendipine / sodium alginate on chronic heart failure

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PUM

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Abstract

The invention relates to a nitrendipine-containing medicine composition. Active ingredients of the nitrendipine-containing medicine composition comprise nitrendipine and polysaccharide sulfate, preferably, the weight ratio of nitrendipine to polysaccharide sulfate is 1 to (5 to 10). According to the medicine composition disclosed by the invention, all complicating diseases of hypertensive patientscan be effectively cooperatively prevented, a long-term survival rate of patients is increased, and meanwhile, the nitrendipine-containing medicine composition has a good prevention effect on heart failure for the hypertensive patients.

Description

technical field [0001] The invention relates to a western medicine compound, in particular to a nitrendipine pharmaceutical composition for treating hypertension and heart failure, which contains a small dose of nitrendipine. Background technique [0002] Heart failure is a common complication of hypertension. Epidemiological studies have shown that 40%-50% of heart failure is caused by hypertension. The higher your blood pressure, without treatment, the more likely you are to develop heart failure. Someone followed up 5314 hypertensive patients for 14.1 years, and 392 cases developed heart failure. Hypertension has been considered as the main risk of left ventricular hypertrophy and myocardial infarction, and left ventricular hypertrophy and myocardial infarction can cause cardiac insufficiency. Therefore, Hypertension plays an important role in the course of heart failure. Nitrendipine, used for coronary heart disease and hypertension, especially in patients with these t...

Claims

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Application Information

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IPC IPC(8): A61K31/737A61K31/4422A61P9/12A61P9/04
CPCA61K31/737A61K31/4422A61K2300/00
Inventor 赵明亮
Owner NANJING ZHENGLIANG MEDICAL TECH
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