Traditional Chinese medicine composition for treating neurodegenerative disease

Abstract

The invention discloses a traditional Chinese medicine composition for treating neurodegenerative diseases, which consists of the following traditional Chinese medicines in parts by weight: 2-60 parts of Smilax smilax, 1-30 parts of Gastrodia elata, and 1-30 parts of Angelica sinensis. The traditional Chinese medicine composition can obviously promote the proliferation of nerve cells and inhibit the death of nerve cells, and the combination of traditional Chinese medicines can play a synergistic effect compared with a single traditional Chinese medicine; it can be used in the Parkinson's disease model caused by MPTP in vitro. Reduce nerve cell death and restore the normality of mice, and be used in the Parkinson's disease model caused by rat 6-hydroxydopa, which can restore function and reduce brain necrosis area; the traditional Chinese medicine composition of the present invention can regenerate and replace dead Nerve area, to treat or prevent neurodegenerative diseases, reduce the activation of microglial cells in diseased tissue, and then protect nerve tissue, thereby reducing or alleviating, or even improving neuromotor function and improving a series of symptoms .

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating neurodegenerative diseases. Background technique [0002] Neurodegenerative disease is a disease state in which cells and neurons of the brain and spinal cord are lost. The brain and spinal cord are composed of neurons. Neurons have different functions. Neurodegenerative diseases are caused by the loss of neurons or their myelin sheath. Aggravating over time to lead to functional impairment, neurodegenerative diseases are phenotypically divided into two groups: those affecting movement and those affecting memory and associated dementia. [0003] Parkinson's Disease (PD) is a diagnostic concept commonly used by clinical neurologists, specifically referring to the following symptoms caused by various reasons (cerebrovascular disease, cerebral arteriosclerosis, infection, poisoning, trauma, drugs and genetic degener...

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Problems solved by technology

[0004] At present, PD is still mainly treated with drugs to restore the balance of striatal DA (dopamine) and Ach (acetylcholine) transmitter systems, and to use drugs that can resist cholinergic and improve DA transmitter function. Commonly used drugs for the treatment of Parkinson's disease include compound Levodopa preparations, dopamine receptor agonists, monoamine oxidase inhibitors, anticholinergic agents, and amantadine, etc., the main effect of these drug treatments is to improve symptoms, but they cannot prevent the progression of the disease. Dependence will aggravate the disease over time, making various physiological functions worse or even exhausted

In recent years, with the vigorous development of traditional Chinese medicine in my country, more and more scholars have extended the research and exploration of PD treatment to the field of traditional Chinese medicine, and screened out some traditional Chinese medicine compositions that are effective in the treatment of PD from many traditional Chinese medicine compounds, but In the past, the use of traditional Chinese medicine was mainly based on experience summarization, lacking strict scientific proof basis, unable to be widely used in clinical treatment, and it is difficult to promote research on the mechanism of action of traditional Chinese medicine compositions

[0005] Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and progressive development. Behavior changes and other generalized dementia are characterized by symptoms, and the etiology is unknown so far. Similarly, there are some traditional Chinese medicine compositions used to treat AD in the prior art. However, traditional Chinese medicines used in the past are mainly based on experience summaries, lacking strict scientific evidence, and cannot be widely used. It is also difficult to promote the research on the mechanism of action of traditional Chinese medicine compositions when applied to clinical treatment

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