Complex probiotic for treating and preventing allergic diseases as well as preparation method and preparation of complex probiotic

A technology for compounding probiotics and allergic diseases, applied in allergic diseases, respiratory diseases, bacteria used in food preparation, etc., can solve the problems of immaturity development, etc. Effects of abundance and diversity

Inactive Publication Date: 2018-02-09
宁波绿康康复科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the specific prevention and treatment of asthma (asthma) by biotechnology in the current medical field has not yet maturely developed.

Method used

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  • Complex probiotic for treating and preventing allergic diseases as well as preparation method and preparation of complex probiotic
  • Complex probiotic for treating and preventing allergic diseases as well as preparation method and preparation of complex probiotic
  • Complex probiotic for treating and preventing allergic diseases as well as preparation method and preparation of complex probiotic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Present embodiment formula is as follows:

[0044] Strain Composition 0.05g

[0045] fructooligosaccharides 1.45g

[0046] Wherein the formula (weight composition) of bacterial strain composition is as follows:

[0047]

[0048] The preparation method of this compound probiotic is as follows:

[0049] The preparation method of above-mentioned composite probiotics is characterized in that comprising the following steps:

[0050] 1) Select a single colony of Lactobacillus salivarius, Lactobacillus salivarius, Bifidobacterium animalis, Lactobacillus johnsonii, Lactobacillus paracasei, and Lactobacillus reuteri to inoculate into a 2L culture bottle, and let stand at 35°C for 24 hours;

[0051] 2) Then move to the fermenter to carry out fermentation culture in the presence of culture medium, and scale up the culture to 200L within 24 hours at 35°C;

[0052] 3) Continue the scale-up culture in the presence of the culture medium in the fermenter, and scale up to 2T with...

Embodiment 2

[0058]Present embodiment formula is as follows:

[0059] Strain Composition 0.05g

[0060] fructooligosaccharides 1.45g

[0061] Wherein the formula (weight composition) of bacterial strain composition is as follows:

[0062]

[0063] All the other contents are the same as in Example 1.

[0064] In this example, the obtained powdery composite probiotics are prepared into capsules for convenient consumption.

Embodiment 3

[0066] Present embodiment formula is as follows:

[0067]

[0068] The powdery bacterial strain composition is added into olive oil to prepare oil drops; the powdery bacterial strain composition: olive oil=0.01 g: 5 ml.

[0069] Olive oil can also be substituted with sunflower oil.

[0070] The effect of the probiotic composition prepared in Example 3 was verified.

[0071] 【Experimental animals】

[0072] The present invention is through 6~8 week SPF level (Specific pathogen Free (SPF)), BALB / c male mouse (purchased from the albino laboratory mouse of Fourth Military Medical University Experimental Animal Center) is randomly divided into 3 The control group (Control), the asthma group (OVA) and the probiotic composition intervention group (OVA+LK) were divided into two groups, 25 rats in each group. They were raised in the animal room of the Basic Department of the Fourth Military Medical University, with a constant room temperature of 21-25°C, a humidity of 50%-65%, and...

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Abstract

The invention relates to complex probiotic for treating and preventing allergic diseases as well as a preparation method and a preparation of the complex probiotic. The complex probiotic is characterized by being prepared from strain composition shown in the description in percentage by weight.

Description

technical field [0001] The present invention relates to a compound probiotic formula, a food composition and a pharmaceutical composition prepared by using the compound probiotic, in particular to a compound probiotic for treating and preventing allergic diseases, a preparation method thereof, a food composition and a medicine Formulation of the composition. Background technique [0002] Asthma (also known as asthma) is a chronic inflammatory disease of the airway. Due to its recurrent symptoms and various variations, it can cause patients to have symptoms such as wheezing, coughing, chest tightness, chest tightness, and dyspnea. Therefore, a considerable number of patients are troubled. The medical profession generally believes that asthma is not only caused by genes, but also related to allergens (allergens) in environmental factors to a considerable extent. [0003] Usually there is immunoglobulin E (Immunoglobulin E, referred to as IgE) in the antibody of mammals, this ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A61P37/08A61P11/06A23L33/135A23G3/36
CPCA23G3/366A23L33/135A61K35/747A23V2002/00A23V2400/145A23V2400/151A23V2400/165A23V2400/173A23V2400/181A23V2400/515A61K2300/00A23V2200/304
Inventor 陈信岳
Owner 宁波绿康康复科技有限公司
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