Preparation method of filler for efficiently purifying phosphatidylcholine

A high-efficiency technology for purifying phosphatidylcholine, applied in separation methods, chemical instruments and methods, alkali metal compounds, etc., to achieve the effects of improving stability, good mechanical strength, and high purity

Inactive Publication Date: 2018-02-09
常州嘉众新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the defect that it is difficult to avoid mixing heavy metals such as Al and produce a large amount of discarded Al2O3 when purifying phosphatidylcholine by the all-solvent method in the prior art, the present invention provides a method for preparing a filler for efficiently purifying phosphatidylcholine

Method used

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  • Preparation method of filler for efficiently purifying phosphatidylcholine
  • Preparation method of filler for efficiently purifying phosphatidylcholine
  • Preparation method of filler for efficiently purifying phosphatidylcholine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method for a filler for efficiently purifying phosphatidylcholine, comprising the following steps:

[0034] 1), uniformly mix high-purity water with a resistivity greater than 18.2MΩ and a surfactant to obtain an aqueous solution with a surfactant concentration of 30g / L, that is, the water phase; the surfactant consists of 1.8% by weight Tween 20 and 0.01% by weight % sodium dodecyl sulfonate composition;

[0035] 2), according to the weight ratio of 10 parts by weight of methyl acrylate, 80 parts by weight of divinylbenzene and 10 parts by weight of N-vinylpyrrolidone, mix uniformly to obtain an oil phase; The total content of m-divinylbenzene and p-divinylbenzene is greater than 80%;

[0036] 3) Add the oil phase to the water phase under shearing and stirring to form a uniform and stable oil-in-water O / W emulsion, use free radicals to initiate and heat up to 40°C to initiate polymerization, filter with filter membrane or filter paper and wash 3 times, ...

Embodiment 2

[0039] A preparation method for a filler for efficiently purifying phosphatidylcholine, comprising the following steps:

[0040] 1), the resistivity is greater than the high-purity water of 18.2MΩ and tensio-active agent are evenly mixed, obtain the aqueous solution that tensio-active agent concentration is 18g / L, i.e. water phase; Surfactant is made up of Triton X-65 of 1.2% by weight and Composition of 0.2% sodium dodecylbenzenesulfonate by weight percentage;

[0041] 2), according to the weight ratio of 16 parts by weight of 2-ethyl methacrylate, 70 parts by weight of divinylbenzene and 14 parts by weight of N-vinylpyrrolidone, mix uniformly to obtain an oil phase; The total content of divinylbenzene, m-divinylbenzene and p-divinylbenzene is greater than 80%.

[0042] 3) Add the oil phase to the water phase under shearing and stirring to form a uniform and stable oil-in-water O / W emulsion, use free radicals to initiate and heat up to 80°C to initiate polymerization, filter...

Embodiment 3

[0045]A preparation method for a filler for efficiently purifying phosphatidylcholine, comprising the following steps:

[0046] 1), the resistivity is greater than the high-purity water of 18.2MΩ and tensio-active agent are evenly mixed, obtain the aqueous solution that tensio-active agent concentration is 3g / L, i.e. water phase; Surfactant consists of Triton X-100 of 0.3% by weight and Composition of 0.5% sodium dodecyl sulfonate by weight percentage;

[0047] 2), according to the weight ratio of 35 parts by weight of 2-methyl methacrylate, 60 parts by weight of divinylbenzene and 20 parts by weight of N-vinylpyrrolidone, mix uniformly to obtain an oil phase; The total content of divinylbenzene, m-divinylbenzene and p-divinylbenzene is greater than 80%.

[0048] 3), at room temperature, add azobisisobutyronitrile (0.2 g) to the above oil phase solution, stir to dissolve, then add to the above water phase solution, shear and stir (domestic S312-90 mechanical stirrer, The rot...

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Abstract

The invention discloses a preparation method of filter for efficiently purifying phosphatidylcholine. The preparation method comprises the following steps: firstly, mixing a non-ionic surfactant and an anionic surfactant with water to obtain an aqueous phase; secondly, mixing 10 to 35 parts of acrylate, 60 to 80 parts of divinyl benzene and 10 to 20 parts of N-vinylpyrrolidone according to the mass ratio to obtain an oil phase; thirdly, mixing the aqueous phase with the oil phase to obtain oil-in-water emulsion; igniting emulsion polymerization by free radical, filtering by filtering, washingand drying filter paper to obtain macroporous resin microsphere filler; fourthly, reacting a weak polar reagent or a weak ion reagent to obtain weak polar exchange resin or weak ion exchange resin. The prepared material has the advantages of high purity, good mechanical strength, controllable particle size (100 to 1000 microns), controllable pore volume (0.3 to 1.2cm<3> / g) and controllable pore diameter. The prepared material is suitable for being used as a macroporous resin adsorption material for high-grade chromatography; the separation and purification effect of PC is good, and heavy metals are not easily doped; the material is repeatedly utilized for multiple times, so that generation of solid wastes is greatly reduced.

Description

technical field [0001] The invention belongs to the technical field of preparation of fillers, in particular to a method for preparing fillers for highly efficient purification of phosphatidylcholine. Background technique [0002] Lecithin is a class of natural surfactants. Each phospholipid molecule has a lipophilic part—including two fatty acid chains attached to the glycerin backbone structure, and one composed of phosphorylcholine, choline or Hydrophilic part composed of inositol etc. Due to its amphiphilicity and some special properties, it can form two kinds of emulsifiers, oil-in-water and water-in-oil. Therefore, it has unique biological activity and physiological functions, and is widely used in food, cosmetics, medicine and other industries. Domestically produced lecithin products are generally obtained from hydration oil feet of vegetable oils such as soybean oil and rapeseed oil, or animal brains and egg yolks. Extracted from. With the advancement of soybean p...

Claims

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Application Information

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IPC IPC(8): C08F212/36C08F220/14C08F226/10C08F2/26C08F2/30B01J20/26B01J20/28B01J20/30B01D15/10
CPCC08F212/36B01D15/10B01J20/264B01J20/28004B01J20/28011B01J20/28073B01J20/28076B01J20/28083C08F2/26C08F2/30C08F220/14C08F226/10
Inventor 黄晓张猛刘钰
Owner 常州嘉众新材料科技有限公司
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