Device and method for rabies virus inactivation and inactivator hydrolysis by virtue of disposable bags

A rabies virus and virus inactivation technology, which is applied in the direction of viruses, virus/bacteriophage, biochemical cleaning equipment, etc., can solve the problems of insufficient inactivation, antigen loss, etc., to reduce the risk of material splashing, damage, and reduce The effect of production costs
CN107746797AActive Publication Date: 2018-03-02SHANDONG YIDU BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG YIDU BIOTECH
Publication Date
2018-03-02

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Abstract

The invention provides a device and method for rabies virus inactivation and inactivator hydrolysis by virtue of disposable bags, wherein an inactivating disposable bag is provided with three connecting ports; the three connecting ports include an inflating port which is arranged at the upper side and is connected to an inflating group, and a liquid inlet and a liquid outlet which are arranged atthe bottom; the liquid inlet is connected to a liquid filling group and the liquid outlet is connected to a drainage group; a built-in stirrer is arranged in the center of the bag, wherein the inflating group is composed of a bag-type filter, a silicone tube and a pipeline clamp, and the sterile bag covers the external part of the bag-type filter; the liquid filling group is formed by sequentiallyconnecting a connector B, a silicone tube, a pipeline clamp, a tee joint and an EZD valve; and another opening of the tee joint is connected to a silicone tube, a pipeline clamp and a connector A. The device provided by the invention has the advantages that the disposable bags are transformed and reasonably used, so that a virus liquid inactivation / hydrolysis method is improved; therefore, a riskof failing in virus inactivation is reduced, antigen loss is lowered and production cost is reduced.
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Description

technical field

[0001] The invention relates to the field of virus vaccine production, in particular to a device and method for inactivating rabies virus and hydrolyzing an inactivating agent using a disposable bag. Background technique

[0002] The containers used for the inactivation of the virus stock solution in the current vaccine production workshop are mainly 20L Nalgene plastic buckets or stainless steel tanks. Disposable bags are mainly used for the preparation, storage and transfer of solutions required in production. Before using 20L barrels or stainless steel tanks for rabies virus inactivation, autoclaving, cleaning verification, and detection of detergent / disinfectant residues are required. Disposable bags have complete manufacturer verification support and can be used directly for large-scale production It can reduce the cleaning and sterilization links, reduce the space occupied by equipment, and the cost is relatively low.

[0003] Using a 20L bucket or st...

Claims

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