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Compound ivermectin tablet and preparation method thereof

A technology of ivermectin tablets and ivermectin, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of large differences in properties and difficulty in making tablets by compounding, and achieve uniformity Good degree, improve the use effect and safety performance, and promote the effect of dissolution

Inactive Publication Date: 2018-03-06
佛山市雷米高动物营养保健科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traits of ivermectin, fenbendazole and praziquantel are quite different, and the traits of each drug excipient are also different
Therefore, ivermectin, fenbendazole and praziquantel are difficult to compound into tablets

Method used

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  • Compound ivermectin tablet and preparation method thereof
  • Compound ivermectin tablet and preparation method thereof
  • Compound ivermectin tablet and preparation method thereof

Examples

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Effect test

preparation example Construction

[0052] A preparation method of compound ivermectin tablets includes the following steps:

[0053] 1) Weighing and sieving: Weigh ivermectin, fenbendazole, praziquantel, disintegrants, fillers, lubricants, adhesives and other auxiliary materials according to the above-mentioned parts by weight. Ivermectin, fenbendazole, praziquantel and auxiliary materials were crushed and passed through a 60-120 mesh sieve for processing. Optionally, the auxiliary material also includes a flavoring agent and a preservative, and the flavoring agent and the preservative are respectively weighed according to the aforementioned weight parts.

[0054] 2) Preparation of ivermectin solid dispersion: add the sieved ivermectin to absolute ethanol to completely dissolve it, then add part of the sieved filler and mix well, then dry, crush and sieving treatment , The ivermectin solid dispersion is prepared, wherein the ivermectin content in the ivermectin solid dispersion is 1%-5%.

[0055] In one embodiment, ...

Embodiment 1-12

[0076] The components of the compound ivermectin tablets in Examples 1-12 are shown in Table 1. The values ​​corresponding to various raw materials in Table 1 are the weight parts of the raw materials.

[0077] Table 1 Composition of compound ivermectin tablets

[0078]

[0079] 1. The preparation methods of Examples 1-6 are as follows:

[0080] 1) Weigh ivermectin, fenbendazole, praziquantel, crospovidone, lactose, microcrystalline cellulose, maltodextrin, beef flavor, magnesium stearate, Povidone and ethyl p-hydroxybenzoate. The weighed raw materials are respectively pulverized and passed through a 100-mesh sieve for processing.

[0081] 2) Add the ivermectin and ethyl p-hydroxybenzoate to absolute ethanol to completely dissolve it, and then add part of the lactose to mix well, and dry it in an oven at a temperature of 55℃-60℃ for 4-5 After hours, pulverized and sieved through a 100-mesh sieve to prepare an ivermectin solid dispersion containing 1% ivermectin.

[0082] 3) The povi...

Embodiment 10-12

[0093] 3. The preparation methods of Examples 10-12 are as follows:

[0094] 1) Weigh ivermectin, fenbendazole, praziquantel, crospovidone, lactose, beef flavor, magnesium stearate, ethyl p-hydroxybenzoate, and polyvinyl chloride according to the above-mentioned weight parts. ketone. The weighed raw materials are respectively pulverized and passed through a 100-mesh sieve for processing.

[0095] 2) Add the ivermectin and ethyl p-hydroxybenzoate to absolute ethanol to completely dissolve, and then add part of lactose to mix well, and dry it in an oven at a temperature of 55°C-60°C for 4-5 hours. It is crushed and sieved through a 100-mesh sieve to prepare an ivermectin solid dispersion containing 1% ivermectin.

[0096] 3) The povidone sieved in step 1) is added to purified water to prepare an aqueous solution of povidone with a concentration of 3% (w / v).

[0097] 4) The fenbendazole, praziquantel, crospovidone, beef flavor, remaining lactose and the ivermectin solid dispersion prep...

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Abstract

The invention relates to a compound ivermectin tablet and a preparation method thereof. The compound ivermectin tablet is mainly prepared from the following raw materials in parts by weight: 0.01-0.05part of ivermectin, 5-10 parts of fenbendazole, 2-5 parts of praziquantel, 3-10 parts of a disintegrating agent, 61-91 parts of a filling agent, 1-3 parts of a lubricating agent and 0.3-1 part of anadhesive. The compound ivermectin tablet is high in uniformity and excellent in using effect.

Description

Technical field [0001] The invention relates to the technical field of antiparasitic drugs, in particular to a compound ivermectin tablet and a preparation method thereof. Background technique [0002] With the improvement of economic capacity, more and more people keep dogs and cats as pets. For example, dogs can not only add fun to people's ordinary life, but also relieve people's inner loneliness and stress. However, dogs are mammals and are susceptible to parasitic diseases such as nematodes, tapeworms, and trematodes. If they cannot be treated in time, it will not only affect the health of the dogs, but also increase the risk of human infection with parasitic diseases. In addition, because dogs and other mammals are also prone to cross-infection with pathogenic parasites in their daily lives, and different pathogens and parasites can infect each other, they may suffer from multiple causes of diseases. [0003] Ivermectin is a new type of low-toxic antibiotic antiparasitic dr...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/4184A61K31/4985A61K9/20A61K47/32A61P33/10
CPCA61K31/7048A61K9/2027A61K9/2095A61K31/4184A61K31/4985A61K2300/00
Inventor 刘晓琳高敏易静文
Owner 佛山市雷米高动物营养保健科技有限公司
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