Application of Ganqing Aconitum in the preparation of drugs for inhibiting and killing bovine viral diarrhea virus bvdv
A technology of bovine viral diarrhea and Ganqing aconitum, which is applied in the field of medical engineering, can solve problems such as short protection period, affecting the immune protection effect of vaccines, and mucosal diseases
Active Publication Date: 2020-11-27
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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Problems solved by technology
However, there are limitations or deficiencies in use: 1) Because BVDV is susceptible to fetuses and can cause immunosuppression, it is not recommended to use attenuated vaccines for pregnant cows and cattle showing clinical symptoms
2) Inactivated vaccines can be used in pregnant cows, but the protection period is short and multiple immunizations are required
3) At present, the degree of antigenic variation between different genotypes and subgenotypes is not clear, and this antigenic difference will affect the immune protection effect of vaccination
4) However, when persistently infected cattle are re-infected with cytopathic BVDV, it will cause mucosal disease
Whether Ganqing Aconitum is effective in the prevention and treatment of BVDV is unknown
Method used
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Embodiment 1
[0020] Drug Examples:
[0021] The Tibetan medicine for inhibiting or killing BVDV is prepared by the following method:
[0022] Ganqing aconitum, a Tibetan medicine, was purchased from the Huanghe Traditional Chinese Medicine Market in Lanzhou City. Take 100g of Ganqing aconitum and add 1L of water to extract it by water extraction for 30 minutes, then concentrate the extract to about 200mL, and freeze-dry it into powder by lyophilizer Finally, seal it and store it in the dark at 4°C for later use.
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The invention discloses application of aconitum tanguticum to preparation of medicines for inhibiting and killing bovine viral diarrhea virus (BVDV). The application has the following beneficial effects: the invention provides the application of the aconitum tanguticum to preparation of the medicines for inhibiting and killing BVDV, a Tibetan medicine serves as a research object, the aconitum tanguticum aqueous extract is screened out and has a certain inhibition effect on the BVDV on an MDBK cell model, the effect of directly killing the virus is better than the adsorbing and blocking effectand the coping and blocking effect. Foundation is laid for prevention and treatment of the BVD disease and research and development of medicines; and the application has the following advantages: thenovel pharmacological action of the aconitum tanguticum is discovered, the aconitum tanguticum can serve as a candidate medicine for preventing and treating BVDV and / or eliminating BVDV infection, canbe used singly and can also be used in a formula.
Description
technical field [0001] The invention relates to the technical field of medical engineering, in particular to the application of Ganqing Aconitum in the preparation of medicines for inhibiting and killing bovine viral diarrhea virus BVDV. Background technique [0002] Bovine viral diarrhea (BVD), also known as bovine viral diarrhea-mucosal disease, is an acute infectious disease caused by bovine viral diarrhea virus (BVDV), which is listed as a second-class infectious disease in my country. Clinical symptoms include fever, loss of appetite, diarrhea, and typical mucosal lesions. Cattle of all ages are susceptible. But it mainly affects young cattle aged 6-24 months. According to the nucleotide sequence comparison of viral RNA, there are at least two genotypes of BVDV, BVDV-1 and BVDV-2, and each genotype can be divided into cytopathic type and non-cytopathic type. Serological survey showed that BVDV presents a global distribution. [0003] When infected with BVDV at the f...
Claims
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IPC IPC(8): A61K36/714A61P1/12A61P31/14
CPCA61K36/714A61K2236/331A61K2236/51
Inventor 李建喜王旭荣张康王学智王丹阳张凯张景艳王磊仇正英
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS