Application of fructus chebulae in preparing medicine for inhibiting and killing BVDV (bovine viral diarrhea virus)

Abstract

The invention discloses application of fructus chebulae in preparing a medicine for inhibiting and killing BVDV (bovine viral diarrhea virus). The application of the fructus chebulae in preparing themedicine for inhibiting and killing the BVDV has the beneficial effects that the Tibetan medicine is used as a study object, and the screened fructus chebulae water extract has certain inhibition on the BVDV in a MDBK(Madin-darby-Bovine-Kidney) model; the direct killing function on viruses is better than both the adsorption blocking function and the duplicating blocking function, and a foundationis laid for the preventing and controlling of BVD diseases and the study and development of medicines; the novel pharmacologic action of the fructus chebulae is found, the fructus chebulae can be usedas a candidate medicine for preventing and controlling the BVDV and/or clearing the infection of BVDV, and the fructus chebulae can be singly used or jointly used.

Description

technical field [0001] The invention relates to the technical field of medical engineering, in particular to the application of Myrobalan in the preparation of medicines for inhibiting and killing bovine viral diarrhea virus BVDV. Background technique [0002] Bovine viral diarrhea (BVD), also known as bovine viral diarrhea-mucosal disease, is an acute infectious disease caused by bovine viral diarrhea virus (BVDV), which is listed as a second-class infectious disease in my country. Clinical symptoms include fever, loss of appetite, diarrhea, and typical mucosal lesions. Cattle of all ages are susceptible. But it mainly affects young cattle aged 6-24 months. According to the nucleotide sequence comparison of viral RNA, there are at least two genotypes of BVDV, BVDV-1 and BVDV-2, and each genotype can be divided into cytopathic type and non-cytopathic type. Serological survey showed that BVDV presents a global distribution. [0003] When infected with BVDV at the fertiliz...

AI Technical Summary

Problems solved by technology

However, there are limitations or deficiencies in use: 1) Because BVDV is susceptible to fetuses and can cause immunosuppression, it is not recommended to use attenuated vaccines for pregnant cows and cattle showing clinical symptoms

2) Inactivated vaccines can be used in pregnant cows, but the protection period is short and multiple immunizations are required

3) At present, the degree of antigenic variation between different genotypes and subgenotypes is not clear, and this antigenic difference will affect the immune protection effect of vaccination

4) However, when persistently infected cattle are re-infected with cytopathic BVDV, it will cause mucosal disease

Tibetan medicine is an important part of traditional Chinese pharmacy in my country. It has a unique theoretical system and strong national characteristics. It has a long history and clinical application foundation. However, some new uses and new pharmacological effects of medicines still need to be further explored. Research

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