Dropping pills containing spica prunellae extract and preparation method of dropping pills

A technology of Prunella vulgaris extract, which is applied to drop pills containing Prunella vulgaris extract, and the field of preparation of the drop pills can solve the problems of not disclosing the preparation of Prunella vulgaris extract, etc.

Active Publication Date: 2018-04-17
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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  • Dropping pills containing spica prunellae extract and preparation method of dropping pills
  • Dropping pills containing spica prunellae extract and preparation method of dropping pills
  • Dropping pills containing spica prunellae extract and preparation method of dropping pills

Examples

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Effect test

preparation example 1

[0052] Preparation Example 1-Prunella vulgaris Extract A

[0053] The preparation method of Prunella vulgaris extract of the present invention is:

[0054] (1) Extract Prunella vulgaris with water as the extraction solvent, heat and reflux for extraction twice, add 10 times the amount of water for extraction for 1 hour each time, combine the extracts, concentrate the extracts under reduced pressure, and dry to obtain the crude extract of Prunella vulgaris.

[0055] (2) The Prunella vulgaris crude extract is dispersed in deionized water to obtain a sample solution whose content of the Prunella vulgaris crude extract is 31g / 100ml, the sample solution is placed on an AB-8 macroporous resin column, and 2 Double volume of deionized water, 3 times of volume of 20 vol% ethanol aqueous solution and 5 times of volume of 50 vol% ethanol aqueous solution were used as eluent, and gradient elution was carried out.

[0056] (3) Collect the eluate after elution with 50 vol% ethanol aqueous...

preparation example 2

[0057] Preparation Example 2-Prunella vulgaris Extract B

[0058] (1) Use 70vol% ethanol aqueous solution as the extraction solvent to extract Prunella vulgaris by ultrasonic method, ultrasonically extract twice at 45°C, add 20 times the amount of ethanol aqueous solution for extraction for 1 hour each time, combine the extracts, concentrate under reduced pressure until there is no alcohol smell, and dry , to obtain the crude extract of Prunella vulgaris.

[0059] (2) Disperse the Prunella vulgaris crude extract in water to obtain a sample solution whose content of the Prunella vulgaris crude extract is 31g / 100ml, place the sample solution on an AB-8 macroporous resin column, and use 2 times the volume successively Deionized water, 3 times the volume of 20 vol% ethanol aqueous solution and 5 times the volume of 70 vol% ethanol aqueous solution were used as eluents to carry out gradient elution.

[0060] (3) Collect the eluate after elution with 70 vol% ethanol aqueous solut...

preparation example 3

[0062] (1) Extract Prunella vulgaris with water as the extraction solvent, ultrasonically extract 3 times, ultrasonic temperature is 35°C, add 10 times the amount of water for extraction for 1.5 hours each time, combine the extracts, concentrate the extracts under reduced pressure, and dry to obtain the crude extract of Prunella vulgaris ;

[0063] (2) The Prunella vulgaris crude extract is dispersed in deionized water to obtain a sample solution whose content of the Prunella vulgaris crude extract is 50g / 100ml, and the sample solution is placed on an AB-8 macroporous resin column, followed by Using 4 times the volume of deionized water, 2 times the volume of 15vol% ethanol aqueous solution and 5 times the volume of 60vol% ethanol aqueous solution as the eluent, carry out gradient elution;

[0064] (3) Collect the eluate after elution with 60 vol% ethanol aqueous solution, concentrate and dry to obtain Prunella vulgaris extract.

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Abstract

The invention discloses dropping pills containing a spica prunellae extract. The dropping pills comprise the spica prunellae extract and a matrix, wherein the spica prunellae extract is obtained through the following steps: spica prunellae is extracted with water or an ethanol aqueous solution as an extraction solvent, and a crude spica prunellae extract is obtained; the crude spica prunellae extract is loaded on a macroporous resin column and sequentially subjected to gradient elution with water, 10vol%-30vol% of an ethanol aqueous solution and 50vol%-95vol% of an ethanol aqueous solution; aneluate obtained after elution with 50vol%-95vol% of the ethanol aqueous solution is concentrated and dried, and the dropping pills are obtained. The dropping pills containing the spica prunellae extract have significant ahypnia prevention and treatment effects.

Description

technical field [0001] The invention relates to a drop pill with sedative and hypnotic effect, especially a drop pill containing Prunella vulgaris extract, and also relates to a preparation method of the drop pill. Background technique [0002] Insomnia refers to a subjective experience of patients who are not satisfied with sleep time and (or) quality and affect daytime social function. Clinical intervention methods for insomnia can be divided into non-drug treatment and drug treatment. Drug treatment is mainly Western medicine, but the main purpose of most drugs is not to treat insomnia. Long-term use of sleeping pills may cause adverse reactions such as drowsiness, forgetfulness, and allergies, and even produce tolerance and addiction, which will aggravate insomnia symptoms and induce insomnia. depression etc. People pay more and more attention to the therapeutic effect of traditional Chinese medicine on insomnia. [0003] Insomnia is called insomnia, insomnia, dim eye...

Claims

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Application Information

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IPC IPC(8): A61K36/536A61K9/20A61P25/20
CPCA61K9/006A61K9/2031A61K36/536A61K2236/331A61K2236/333A61K2236/39A61K2236/55
Inventor 王庆国王雪茜屈会化程发峰赵琰孔慧魏震孙良明
Owner BEIJING UNIV OF CHINESE MEDICINE
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