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Apparatus and method for rapid crystallization of biomolecules

A biomolecular and rapid technology, applied in the direction of evaporation, separation and crystallization, solution crystallization, etc., can solve problems such as low efficiency and achieve the effect of improving work efficiency

Active Publication Date: 2020-03-17
恩施诚实通中药材产业发展有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the method of crystallization of biomolecules mainly adopts centrifugal treatment through a centrifugal device first, and then under the action of an external electric field, the material is separated, and finally crystallized in a crystallization tank. and crystallization tank for multiple transfers, and in this way centrifugation, external electric field and close treatment, this method is inefficient; so there is an urgent need for a device and method for rapid crystallization of biomolecules to solve this problem

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  • Apparatus and method for rapid crystallization of biomolecules

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Embodiment Construction

[0025] In order to make the purpose, technical solution and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0026] In the following description, references to "one embodiment," "an embodiment," "an example," "example," etc. indicate that such described embodiment or example may include a particular feature, structure, characteristic, property, element, or limitations, but not every embodiment or example necessarily includes the specific feature, structure, characteristic, property, element or limitation. Additionally, repeated use of the phrase "according to one embodiment of the present application" does not necessarily refer to the same embodiment, although it may.

[0027] For simplicity, some technical features known to those skilled in the art are omitted from the following description.

[0028] According to an embodiment of the prese...

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Abstract

The invention provides biomolecule rapid crystallization equipment and a method. The equipment includes a cylindrical main tank with a feeding tube connected at the bottom and other components, can realize the simultaneous treatment of centrifugation, application of an external electric field and crystallization, and also can perform drying treatment on the treated materials. The method includes centrifugal treatment of a feed solution and application of an external electric field at the same time, can realize feed solution separation and concentration, and other steps. The equipment and method provided by the invention can be employed to acquire crystals with almost identical purity to the existing process, and 4-6h working time can be saved.

Description

technical field [0001] The invention specifically relates to a device and method for rapid crystallization of biomolecules. Background technique [0002] Biomacromolecules are generally separated from fermentation broth or enzyme reaction liquid or animal and plant cells. Compared with general chemicals, the separation and purification of biomacromolecules has the following characteristics: the content of biomacromolecules in the raw material liquid is generally low; The raw material liquid is a mixture of multiple components with a wide molecular weight distribution, including large molecular weight substances such as nucleic acids, proteins, polysaccharides, lipids, phospholipids and lipopolysaccharides, as well as low molecular weight substances such as amino acids, organic acids and alkalis; the stability of biological macromolecules Its chemical properties are not stable enough, and it is easily degraded by heat and acid, which makes the separation and purification cond...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D9/02
CPCB01D9/0031
Inventor 邓仕明艾训儒邓志军姚兰刘欢
Owner 恩施诚实通中药材产业发展有限公司
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