MiRNA marker related to colorectal cancer metastasis in tissues and application thereof

A colorectal cancer and marker technology, applied in the fields of biotechnology and medicine, can solve the problems of high complications, difficult to become a patient with colorectal cancer liver metastases, insufficient typical indications, etc., and achieve the effect of improving accuracy

Active Publication Date: 2018-05-08
广西壮族自治区肿瘤防治研究所
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Problems solved by technology

[0006] Traditional screening methods such as laparoscopy, fine-needle aspiration cytology and imaging methods such as enhanced computed tomography (CT), magnetic resonance imaging (MRI) are invasive, high in complications or insufficient in typical indications, Therefore, it is difficult to become an effective method for early screening of patients with colorectal cancer liver metastases

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  • MiRNA marker related to colorectal cancer metastasis in tissues and application thereof
  • MiRNA marker related to colorectal cancer metastasis in tissues and application thereof
  • MiRNA marker related to colorectal cancer metastasis in tissues and application thereof

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Embodiment Construction

[0023] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0024] It should be noted that the experimental methods described in the following embodiments, unless otherwise specified, are conventional methods, and the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0025] Part I: Bioinformatics analysis and screening of miRNAs associated with colorectal cancer metastasis

[0026] Materials and Methods

[0027] 1. Technical methods and data analysis process (see figure 1 )

[0028] 2. Acquisition of miRNA and gene expression data

[0029] The search keywords of this study in the GEO database are "Colorectal cancer", "Colon cancer", "rectal cancer", "Colonic carcinoma", "Metastasis", "Hepatic metastasis", "livermetastasis", "MicroRNAs". In addition, Google Scholar and Baidu Academic wer...

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Abstract

The invention discloses a miRNA marker related to colorectal cancer metastasis in tissues and application thereof, belonging to fields of biological technology and medical technology. The miRNA markerrelated to colorectal cancer metastasis in tissues is any one or more of miR-96, miR-99b, miR-155, let-7a and let-7b. The screened out miRNA marker related to colorectal cancer metastasis in tissueshas much higher specificity and sensitivity than the tumor marker CEA in clinical use at present in detection of colorectal cancer metastasis, thereby greatly improving the diagnosis accuracy.

Description

technical field [0001] The invention relates to the fields of biotechnology and medical technology. More specifically, the present invention relates to miRNA markers associated with colorectal cancer metastasis in tissues and applications thereof. Background technique [0002] Colorectal cancer (CRC) is one of the most common gastrointestinal cancers and the third leading cause of cancer-related death worldwide. The occurrence of colorectal cancer liver metastasis is a multifactorial and multistep process. Approximately 20–25% of CRC patients are initially diagnosed with liver metastases, and up to 40–50% of patients develop liver metastases after primary tumor resection. Most patients with colorectal liver metastases are not suitable for radical surgical resection, and the five-year survival rate is ≤10%. [0003] The occurrence of liver metastasis in colorectal cancer patients is not only related to abnormal or loss of expression of proto-oncogenes and tumor suppressor ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 张力图刘海洲利基林宁淑芳韦文娥陈伊谭晓玉谢雨萱
Owner 广西壮族自治区肿瘤防治研究所
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