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Application of natural pharmaceutical composition to preparation of anti-hypoxic and anti-radiation drugs or food

A technology of natural medicine and composition, applied in the field of medicine, can solve problems such as difficulty in widespread use, limitation, limited resources, etc., and achieve the effects of preventing acute altitude sickness, improving hypoxia tolerance and radiation resistance.

Active Publication Date: 2018-05-11
ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Anti-hypoxia and anti-radiation drugs are mainly divided into chemical drugs and Chinese patent medicines. Chemical drugs such as acetazolamide, dexamethasone, amifostine, nylestriol, etc., although they have good anti-hypoxia and / or Anti-radiation effect, but it is limited due to its obvious side effects; anti-hypoxia Chinese patent medicines include ginseng, rhodiola rosea, cordyceps, etc., although they can effectively improve the body's hypoxia tolerance and reduce radiation damage, but due to limited resources and Expensive and difficult to promote and use on a large scale

Method used

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  • Application of natural pharmaceutical composition to preparation of anti-hypoxic and anti-radiation drugs or food
  • Application of natural pharmaceutical composition to preparation of anti-hypoxic and anti-radiation drugs or food
  • Application of natural pharmaceutical composition to preparation of anti-hypoxic and anti-radiation drugs or food

Examples

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Effect test

Embodiment 1

[0040] The preparation of embodiment 1 coriander root polysaccharide

[0041] (1) get the tubers of Brassicaceae Brassica genus Cortex in Tibet at an altitude of more than 3000 meters, dry and pulverize to obtain dry powder;

[0042] (2) Take 20kg of dry powder, extract 2 times with 12 times the amount (mass multiple) of distilled water at 95°C, filter for 2 hours each time, and obtain the extract; combine the extracts obtained by the two filtrations, and concentrate to 1 / 4 of the volume of the extract to obtain a concentrated extract;

[0043] (3) Add 3 times volume of ethanol aqueous solution with a mass fraction of 95% to the concentrated extract under continuous stirring, precipitate the polysaccharide in the concentrated extract, filter, collect the precipitate, and freeze-dry the precipitate to obtain coriander root crude polysaccharide;

[0044] (4) After re-dissolving the crude polysaccharide from coriander root with water, use the Sevag method to remove the protein ...

Embodiment 2

[0047] The preparation of embodiment 2 seabuckthorn flavonoids

[0048] (1) take the ripe fruit of seabuckthorn, dry and pulverize to obtain dry powder;

[0049] (2) Take 20 kg of dry powder, use 8 times the amount (solid-liquid ratio) of ethanol with a mass fraction of 70% to reflux extract twice, each time for 2 hours, filter, and concentrate the filtrate under reduced pressure to no alcohol to obtain a crude extract;

[0050] (3) Add 3.0L distilled water to the crude extract, heat to 50°C to dissolve the crude extract, after cooling, extract 5 times with petroleum ether, 3.0L each time, remove the petroleum ether extract phase, and then saturate with n-butanol with water Extract 5 times, 3.0L each time, collect the n-butanol extract phase, concentrate under reduced pressure at 50°C to remove n-butanol, reclaim n-butanol, and freeze-dry to obtain the crude flavonoids of seabuckthorn. The total flavonoid content (aluminum nitrate-sodium nitrite Chromogenic method (mass fract...

Embodiment 3

[0054] This embodiment prepares refined astragalus polysaccharides, refined wolfberry polysaccharides and refined ginkgo flavonoids; wherein, the refined astragalus polysaccharides are extracted from the dried roots of Astragalus membranaceus, and the purity of the refined astragalus polysaccharides (determined by the phenol-sulfuric acid method) is 95.2% (mass fraction) (specific method See: Liu Rongqiang. Astragalus polysaccharide structure and anti-tumor activity [D]. Tianjin University of Science and Technology, 2011); refined Lycium barbarum polysaccharide is extracted from Lycium barbarum dried fruit, and the purity of refined Lycium barbarum polysaccharide (determined by phenol-sulfuric acid method) is 94.1% (mass fraction ) (for specific methods see: Liu Rongqiang. Astragalus polysaccharide structure and anti-tumor activity research [D]. Tianjin University of Science and Technology, 2011); refined ginkgo flavonoids were extracted from the dried leaves of Ginkgo biloba, a...

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Abstract

The invention discloses an application of natural pharmaceutical composition to preparation of anti-hypoxic and anti-radiation drugs or food. The natural pharmaceutical composition is prepared from components in parts by weight as follows: 10-90 parts of common turnip polysaccharide and 10-90 parts of seabuckthorn flavone. The common turnip polysaccharide and the seabuckthorn flavone are combined,and tests prove that the natural pharmaceutical composition has a synergistic effect, can remarkably improve hypoxia tolerance and radiation resistance of an organism and can be used for preparing the drugs and food for preventing acute altitude stress, altitude sickness and radiation damage.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of natural medicine composition in the preparation of anti-hypoxia and anti-radiation medicine or food. Background technique [0002] Oxygen is one of the material bases for the survival of human beings and many organisms, and is closely related to the reproduction and evolution of life. Insufficient intake of oxygen or oxygen metabolism disorder may lead to abnormal function or shape of cells, tissues and organs, and then lead to a series of diseases. [0003] Oxygen and hypoxia are important topics in the basic theory of life sciences. The formation of hypoxia can generally be divided into three categories: the first category is the reduction of oxygen content in the external environment, which makes it impossible to take in enough oxygen during normal physiological activities, such as hypoxia caused by special environments such as plateaus, diving and aviatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P39/00A23L33/105A23L33/125A61K31/715
CPCA23V2002/00A61K31/715A61K36/185A23L33/105A23L33/125A61K2300/00A23V2200/30A23V2250/2116A23V2250/21A23V2250/51
Inventor 楚秉泉何乐
Owner ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
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