The preparation method of 1,7-bis(4-phenylhydroxyl)heptyl-3,5-diol ester

Abstract

The invention discloses a preparation method of 1,7-bis(4-phenylhydroxyl)heptyl-3,5-diol ester, which comprises the following steps: (1) taking bisdemethoxycurcumin as raw material, first carrying out- The reduction reaction of C=C-gets the product 3; (2) then carries out the reduction reaction of the carbonyl under the premise of protecting the hydroxyl group on the benzene ring to get the product 5; (3) the product 5 is subjected to an esterification reaction to get the product 6, and the product 6 is then carried out The deprotection group reaction is to obtain the final product 1,7-bis(4-phenylhydroxyl)heptyl-3,5-diol ester. 1,7-bis(4-phenylhydroxyl)heptyl-3,5-diol ester can be obtained by chemical reaction and deprotection reaction, the reaction procedure is simple, the operation is simple, the cost of raw materials used is low, and the yield is high , suitable for large-scale industrial production of 1,7-bis(4-phenylhydroxy)heptyl-3,5-diol ester.

Description

technical field [0001] The invention relates to the technical field of compound synthesis, more specifically, to a preparation method of 1,7-di(4-phenylhydroxy)heptyl-3,5-diol ester. Background technique [0002] Diphenylheptane compounds are a general term for a class of natural compounds with a 1,7-diphenylheptane core, which can be divided into linear and cyclic compounds according to their structures, and are mainly found in Zingiberaceae plants Compounds with special structures. Its active ingredients have various physiological activities, such as anti-hepatotoxicity, anti-tumor, anti-inflammatory, bile excretion, insecticide, anti-oxidation, etc.; natural linear diphenylheptane compounds, typical structure, diverse and significant physiological activities, in recent years Becoming the focus of attention, 1,7-bis(4-phenylhydroxy)heptyl-3,5-diol ester is also known as 3,5-diacetoxy-1,7-bis(4-hydroxyphenyl) Heptane, which has been proved to have the biological activity ...

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Problems solved by technology

Its active ingredients have various physiological activities, such as anti-hepatotoxicity, anti-tumor, anti-inflammatory, bile excretion, insecticide, anti-oxidation, etc.; natural linear diphenylheptane compounds, typical structure, diverse and significant physiological activities, in recent years Becoming the focus of attention, 1,7-bis(4-phenylhydroxy)heptyl-3,5-diol ester is also known as 3,5-diacetoxy-1,7-bis(4-hydroxyphenyl) Heptane, which has been proved to have the biological activity of inhibiting the proliferation of human T-cell lymphoma cell line HH cells, can be applied to the preparation of medicine or food for the prevention and treatment of psoriasis; prior art for 1,7-two (4-phenylhydroxy ) Heptyl-3, the preparation of 5-diol ester mostly is to obtain through a series of procedures such as purification, chemical chromatography from Zingiberaceae Curcuma rhizome, yet this method prepares 1,7-two (4-phenylhydroxyl) heptane Base-3, the productive rate of 5-diol ester is low, procedure is complicated, and uses various chemical chromatography, and preparation cost is high, is unfavorable for present industry for 1,7-bis(4-phenylhydroxyl) heptyl-3, Large-scale production of 5-diol esters

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