Compound terbinafine hydrochloride cream and preparation method thereof
A technology of terbinafine hydrochloride and nafine cream, which is applied in the field of cream, can solve the problems of low healing efficiency, poor application effect, slow antipruritic onset, etc., and achieve high cure rate and fast antipruritic onset , the effect of low production cost
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[0048] A preparation method for compound terbinafine hydrochloride emulsifiable paste, comprises the following steps:
[0049] 1) Weigh terbinafine hydrochloride, Moutan bark extract, dissolving agent, penetrating agent, cooling agent, emulsifier, diluent, thickener, humectant and water respectively according to the above-mentioned parts by weight.
[0050] 2) Mix the diluent, the thickener, the moisturizing agent and the water, heat to 75°C-85°C to melt, and stir evenly to prepare a mixed solution. Optionally, the stirring speed is 170r / min-180r / min.
[0051] Specifically, the diluent, the thickener, the humectant and the water are heated to 80° C. in a sealed heated stirring tank, mixed and melted / dissolved completely (until clarification), continuously stirred at a speed of 180 r / min, and kept warm.
[0052] 3) Add the emulsifier into the mixed solution, heat to 75°C-85°C for emulsification, and stir evenly to prepare a cream base. Optionally, the stirring speed is 190r / m...
Embodiment 1-6 and comparative example 1-4
[0066] The composition of the compound terbinafine hydrochloride cream in Examples 1-6 and Comparative Examples 1-4 is shown in Table 1. The numerical values corresponding to various raw materials in Table 1 are parts by weight of the raw materials.
[0067] The composition of table 1 compound terbinafine hydrochloride cream
[0068]
Embodiment 1-6 and comparative example 4
[0069] The preparation method of embodiment 1-6 and comparative example 4 is as follows:
[0070] 1) Weigh the diluent, thickener, humectant and water in the amount of the above formula, heat to 80°C in a sealed heating and stirring tank, mix and melt / dissolve completely (until clarification), and then at a speed of 180r / min Stir continuously and keep warm.
[0071] 2) Heat the emulsifier to 30°C to melt it, stir it evenly and add it to the mixture prepared in step 1), stir at a temperature of 80°C at a speed of 200r / min for 20min, and start to cool down after the emulsification is complete. During the process, stir at a speed of 180r / min until the temperature is lowered to 60°C, and keep stirring at the same speed to obtain a cream base.
[0072] 3) Weigh the terbinafine hydrochloride, Moutan cortex extract, cooling agent and penetrating agent in the above formula, mix them with the dissolving agent, heat and dissolve completely at 60° C., keep warm, and prepare the medicina...
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