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A Simultaneous Measurement Method of Angle and Relaxation Time Constant t1 of Gas Spectrum

A technology of relaxation time and gas, which is applied in the direction of using nuclear magnetic resonance spectrum to measure, measure devices, measure magnetic variables, etc., can solve the problems of long sampling time, large fitting error, high hardware requirements, etc., and achieve simple and easy data processing methods The operation and engineering are simple and easy to implement, and the effect of reducing hardware requirements

Active Publication Date: 2019-08-16
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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  • Claims
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Problems solved by technology

In addition, on the one hand, limited by the hardware of the instrument, only a limited number of RF pulses with different excitation angles can be set in the experiment; collection time of
Currently commonly used methods for measuring the RF pulse angle θ are susceptible to T 1 Influenced by relaxation, the sampling time is too long, the fitting error is large, multiple excitation angles need to be set, and the hardware requirements are high
[0004] There are also magnetic resonance imaging methods for excitation angle measurements of hyperpolarized gases, but these methods require multiple breath-holds, resulting in long acquisition times and are susceptible to varying gas volumes at different breath-holds

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  • A Simultaneous Measurement Method of Angle and Relaxation Time Constant t1 of Gas Spectrum
  • A Simultaneous Measurement Method of Angle and Relaxation Time Constant t1 of Gas Spectrum

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Embodiment Construction

[0034] The specific implementation process and effects of the present invention are given below in conjunction with specific examples.

[0035] Angle and relaxation time constant T of a gas spectrum disclosed by the invention 1 Simultaneous measurement method comprising the following steps:

[0036] Step 1. Collect hyperpolarized gas. where hyperpolarized gases include 3 He or 129 Xe or 131 Xe or 83 Kr et al. The collected hyperpolarized gas is stored as a gas or as a solid, wherein the solid is sublimated to a gas upon use.

[0037] Step 2. The research object obtains hyperpolarized gas. The research object includes liquid or solid or biological tissue or animal or human etc.

[0038] Step 3. In a breath-hold, fix the excitation angle θ of the radio frequency pulse, collect the magnetic resonance spectrum of the hyperpolarized gas of the research object, and obtain the free induction decay (FID) of the hyperpolarized gas of the research object under variable repetitio...

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Abstract

The invention discloses an angle and T1 simultaneous measurement method based on a hyperpolarized gas spectrum, and the method comprises the steps: collecting hyperpolarized gas; enabling a research object to obtain the hyperpolarized gas; fixing an excitation angle theta of a radio frequency pulse in one breath holding process, collecting a magnetic resonance spectrum of the hyperpolarized gas ofthe research object, and obtaining a free induction decay signal FID1 of the hyperpolarized gas of the research object in a variable repetition time TR1 and a free induction decay signal FID2 of thehyperpolarized gas of the research object in a fixed repetition time TR2; processing the FID1 and FID2 signals, and obtaining an actual excitation angle theta(r) of the radio frequency pulse and the spin-lattice relaxation time constant T1 of the hyperpolarized gas of the research object. According to the invention, the method can achieve the simultaneous obtaining of the angle and an analytical solution of T1, shortens the sampling time, reduces the requirements for hardware, is easy for engineering implementation, and is simple in data processing.

Description

technical field [0001] The invention relates to the technical field of magnetic resonance spectroscopy, in particular to a gas spectrum angle and relaxation time constant T 1 Simultaneous measurement method. Suitable for precise control of the excitation angle of radio frequency pulses using hyperpolarized gas as a contrast agent, T 1 measurement etc. Background technique [0002] Magnetic Resonance Spectroscopy (MRS) is based on the observation that the nucleus in the sample is excited by a radio frequency (RF) pulse in a magnetic field to generate nuclear magnetic resonance. The electronic system receives the magnetic resonance signal generated by the sample, and the obtained The digital signal is subjected to spectral transformation, and the magnetic resonance spectrum can be reconstructed. Conventional MRS is mostly used for H atoms in water or lipids. For inert gas atoms, the method of spin exchange optical pump is usually used, so that the magnetization vector at n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01R33/44G01R33/46
CPCG01R33/448G01R33/46
Inventor 周欣谢军帅李海东孙献平叶朝辉
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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