Combined medicine for treating colorectal cancer

A technology of colorectal cancer and medicine, which is applied in the field of medicine, achieves the effect of definite curative effect and overcomes large side effects

Active Publication Date: 2018-06-15
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the adverse reactions caused by it include vomiting, delayed diarrhea, neutropenia syndrome, acute cholinergic syndrome, etc. Among them, delayed diarrhea is the main adverse reaction of irinotecan, which is dose-dependent. 24 hours, the incidence rate can reach 90%, severe cases can be fatal
[0003] There are reports on the treatment of colorectal cancer with chemical drugs such as irinotecan and traditional Chinese medicine compositions with large prescriptions. However, there is no drug with small side effects and effective treatment of colorectal cancer.

Method used

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  • Combined medicine for treating colorectal cancer
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0034] 1. Raw materials: Pueraria 90g, Scutellaria baicalensis 54g, Coptidis 54g, Licorice 36g, Paeoniae Alba 30g, Atractylodes macrocephala 30g, Fangfeng 20g, Chenpi 20g, Jujube 30g.

[0035] 2. Preparation method:

[0036] a, weigh the bulk drug of weight ratio;

[0037] b. Put the kudzu root in a round bottom flask, add 15 times the amount of water, decoct for 1 hour, then add the rest of the medicinal materials, decoct for 1.5 hours, filter, combine the two filtrates, and concentrate under reduced pressure at 55°C;

[0038] c. Pour the concentrated medicinal solution into a separatory funnel, perform liquid-liquid extraction with 3 times the amount of chloroform, extract 3 times, combine the extracts, concentrate under reduced pressure at 45°C, and place the concentrated solution in a water bath at 85°C on, dried into a dry paste, that is.

Embodiment 2

[0039] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0040] 1. Raw materials: Pueraria 50g, Scutellaria baicalensis 20g, Coptidis 20g, Licorice 10g, Radix Paeoniae Alba 20g, Atractylodes macrocephala 20g, Fangfeng 10g, Chenpi 10g, Jujube 10g.

[0041] 2. Preparation method:

[0042] a, weigh the bulk drug of weight ratio;

[0043] b. Put the kudzu root in a round bottom flask, add 15 times the amount of water, decoct for 1 hour, then add the rest of the medicinal materials, decoct for 1 hour, filter, combine the two filtrates, and concentrate under reduced pressure at 65°C;

[0044] c. Pour the concentrated medicinal solution into a separatory funnel, perform liquid-liquid extraction with 2 times the amount of chloroform, extract 3 times, combine the extracts, concentrate under reduced pressure at 40°C, and place the concentrated solution in a water bath at 80°C on, dried into a dry paste;

[0045] d, take by weighing 50g of dry past...

Embodiment 3

[0046] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0047] 1. Raw materials: Pueraria 150g, Scutellaria baicalensis 80g, Coptidis 80g, Licorice 50g, Radix Paeoniae Alba 80g, Atractylodes macrocephala 80g, Fangfeng 50g, Chenpi 50g, Jujube 50g.

[0048] 2. Preparation method:

[0049] a, weigh the bulk drug of weight ratio;

[0050] b. Put the kudzu root in a round bottom flask, add 10 times the amount of water, decoct for 1 hour, then add the rest of the medicinal materials, decoct for 1 hour, filter, combine the two filtrates, and concentrate under reduced pressure at 65°C;

[0051] c. Add the concentrated medicinal solution to a chromatographic column equipped with AB-8 weakly polar macroporous adsorption resin, fill the column by wet method, and dynamically adsorb for 2 hours, then elute it with pure water until it is colorless, and then use 50 % ethanol solution was eluted to colorless, collected 50% ethanol eluate, concentrated un...

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Abstract

The invention provides a combined medicine for treating colorectal cancer. The combined medicine comprises medicine compositions for simultaneous or respective administration of preparations with thesame or different specifications and units and irinotecan, as well as a pharmaceutically acceptable carrier. The combined medicine can effectively treat colorectal cancer, can reduce side effects, particularly delayed-onset diarrhea, caused by irinotecan, and provides a new choice for clinical medication.

Description

technical field [0001] The invention relates to a combination drug for treating colorectal cancer, belonging to the field of drugs. Background technique [0002] Colorectal cancer is a common malignant tumor of the digestive tract, accounting for the second place among gastrointestinal tumors. Predilection sites are the rectum and the junction of the rectum and the sigmoid colon, accounting for 60%. The incidence is mostly after the age of 40, and the ratio of male to female is 2:1; the mortality rate accounts for the fourth place, which has a serious threat to human health. With the improvement of my country's economic strength and the improvement of national living standards, its incidence has become increasing trend year by year. Colon cancer is often treated with combined regimens. However, the combination of several drugs has also led to a great increase in drug toxicity, so that the 3-year survival rate and 5-year survival rate of patients are not higher than those of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P1/00A61P35/00A61K31/4745
CPCA61K31/4745A61K36/238A61K36/284A61K36/484A61K36/488A61K36/539A61K36/65A61K36/71A61K36/718A61K36/725A61K36/752A61K2236/331A61K2236/51A61K2236/55A61K2300/00
Inventor 章津铭吴亿晗傅超美杨晓琴王婷游宇张臻刘芳
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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