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Method for extracting high-purity baicalein from scutellaria baicalensis

A technology of baicalein and baicalein, which is applied in the field of medicine, can solve the problems of complex process, high energy consumption, and long time consumption, and achieve the effects of convenient and quick operation, increased baicalein content, and reduced production costs

Inactive Publication Date: 2018-06-15
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process of the invention is complex, time-consuming, high energy consumption, and toxic organic solvents such as acetone, methanol and chloroform remain

Method used

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  • Method for extracting high-purity baicalein from scutellaria baicalensis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 50 g of Scutellaria baicalensis coarse powder, add a small amount of water to incubate at 50°C for 3 hours, add 450 ml of 30% ethanol to extract twice by flash extraction, and filter the extract. The content of baicalein in the extract was determined by high performance liquid chromatography according to the above conditions.

Embodiment 2

[0024] Weigh 50 g of Scutellaria baicalensis coarse powder, add a small amount of water to incubate at 50°C for 3 hours, add 450 ml of 50% ethanol to extract twice by flash extraction, and filter the extract. The content of baicalein in the extract was determined by high performance liquid chromatography according to the above conditions.

Embodiment 3

[0026] Weigh 50 g of Scutellaria baicalensis coarse powder, add a small amount of water to incubate at 50°C for 3 hours, add 450 ml of 70% ethanol to extract twice by flash extraction, and filter the extract. The content of baicalein in the extract was determined by high performance liquid chromatography according to the above conditions.

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Abstract

The invention relates to a method for extracting high-purity baicalein from scutellaria baicalensis. The method comprises the following steps: hydrolyzing scutellaria baicalensis, extracting by usinga flash extraction method, recycling a part of ethanol from an extract, adding a polymeric flocculant for adsorption and clarification, continuously concentrating an adsorption and clarification liquid, and adjusting the pH value of a concentrated liquid with an acid, thereby obtaining baicalein with relatively high purity. The method is simple and convenient in preparation process, good in energyconservation and environment protection, free of residue of toxic solvents in products and applicable to industrial production of baicalein with relatively high purity from scutellaria baicalensis.

Description

technical field [0001] The invention belongs to the field of medicine and relates to extraction and purification methods of active components of traditional Chinese medicines, in particular to a method for extraction and purification of baicalein from Scutellaria baicalensis. Background technique [0002] Scutellaria baicalensis is the dried root of Scutellaria baicalensis Georgi, a plant in the Labiatae family, which has the functions of clearing away heat and dampness, purging fire and detoxifying, stopping bleeding and preventing miscarriage. Pharmacological studies have shown that it has pharmacological activities such as anti-inflammatory, antibacterial, anti-allergic, diuretic, choleretic and antispasmodic. [0003] Patent Publication No. CN104130230A discloses a method for extracting and purifying baicalein from Scutellaria baicalensis. The specific steps are: adding water to the roots of Scutellaria baicalensis and enzymatically hydrolyzing, filtering, adding water t...

Claims

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Application Information

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IPC IPC(8): C07D311/30
CPCC07D311/30
Inventor 汤淮波张腾
Owner XIANGTAN UNIV