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Application of merremia yunnanensis extract in drug preparation

A technology of white cloud melon and extract, applied to the new use field of white cloud melon extract in the pharmaceutical field, can solve the problems of increasing the carotid artery and cerebral blood flow of rabbits, prolonging the survival time of mice, etc., and improving the blood flow state. , the effect of improving microcirculation and prolonging survival time

Inactive Publication Date: 2018-06-22
YUNNAN INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Preliminary research on the chemical composition of Baiyun melon mainly contains flavonoids and saponins. Preliminary pharmacodynamics shows that its alcohol extract has a significant relaxation effect on isolated bovine cerebral artery strips, and can significantly prolong the vascularity after ligation of the common carotid artery. The survival time of rats can significantly increase the carotid artery and cerebral blood flow of rabbits, and it has obvious protective effects on acute pulmonary embolism, respiratory distress and death caused by arachidonic acid antithrombotic, but there is no pharmacological effect related to Baiyun melon extract. and its usage reports

Method used

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  • Application of merremia yunnanensis extract in drug preparation
  • Application of merremia yunnanensis extract in drug preparation
  • Application of merremia yunnanensis extract in drug preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. The white cloud melon medicinal material is cleaned and dried, and then coarsely crushed;

[0027] 2. Take the above-mentioned coarsely crushed medicinal materials and add water to extract twice, add 12 times the amount for the first time, add 8 times the amount for the second time, extract for 1 hour each time, and combine the two extracts;

[0028] 3. The extract was filtered with a membrane, and the filtrate was concentrated under reduced pressure to a specific gravity of 1.30 (60°C) to obtain Baiyun melon liquid extract with a yield of 33.6%;

[0029] 4. Take the above fluid extract and dissolve it in water, then add 0.7% potassium sorbate and 5% glycerin, and finally add water to the specified amount, so that the prepared solution contains 2 grams of Baiyun melon medicinal material per ml, and then use 40% NaOH solution Adjust the pH value to 6.5, mix well, and sterilize to obtain the required Baiyungua oral liquid or mixture for treating cerebrovascular disease...

Embodiment 2

[0031] 1. The white cloud melon medicinal material is cleaned and dried, and then coarsely crushed;

[0032] 2. Take the above coarsely crushed medicinal materials and add 10% ethanol to heat reflux for extraction twice, add 6 times the amount of solvent each time, reflux for 2 hours each time, combine the extracts twice to recover ethanol;

[0033] 3. Add 2 times the amount of water to the extract after recovering the ethanol, boil it, cool it to room temperature, filter it with a membrane, concentrate the filtrate under reduced pressure to a specific gravity of 1.29 (60°C), and set it aside.

[0034] 4. Take the above-mentioned fluid extract, add appropriate amount of sugar powder and dextrin, mix evenly, make granules, vacuum-dry at 60°C, sieve and granulate, pack, and obtain Baiyungua granules for treating cerebrovascular diseases.

Embodiment 3

[0036] 1. The white cloud melon medicinal material is cleaned and dried, and then coarsely crushed;

[0037] 2. Take the above coarsely crushed medicinal materials and add 60% ethanol to heat reflux for extraction 3 times, add 4 times the amount of solvent each time, reflux for 1 hour each time, combine the extracts 3 times to recover ethanol;

[0038] 3. Add 2 times the amount of water to the extract after recovering ethanol, boil it, cool it to room temperature, filter it with a membrane, concentrate the filtrate under reduced pressure until the specific gravity is above 1.30 (60°C), then vacuum dry it at 60°C, crush it, and pass it through 80 mesh Sieve to get the extract powder, the yield is 16.2%;

[0039] 4. Mix 50% by weight extract powder and 50% starch, put it in a ball mill and grind it for 2 hours, mix thoroughly, and make granules with a particle size of over 40 mesh through dry granulation or one-step granulation machine. Add 0.8% magnesium stearate by weight of ...

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Abstract

The invention relates to new application of a natural plant extract in drug preparation, in particular to the application of the natural plant extract in preparing drugs for treating cerebrovascular diseases. The invention relates to application of merremia yunnanensis extract in preparing the drugs for treating the cerebrovascular diseases. The extract is merremia yunnanensis ethanol extract or merremia yunnanensis water extract. According to the merremia yunnanensis extract, underground parts of merremia yunnanensis serve as raw materials, and water or ethanol is adopted to carry out heatingextraction to obtain extract dry powder or liquid extract. Experiment results show that the merremia yunnanensis extract can significantly prolong the survival time of mice under an ordinary pressureand oxygen deficient condition, wherein the average P is smaller than 0.01; the merremia yunnanensis extract has the effect of resisting mouse brain ischemia caused by carotid artery occlusion and has a good protection effect on mouse brain ischemia reperfusion injuries caused by a suture method, and the survival time of the mice can be obviously prolonged after collagen-adrenaline induced in-vivo thrombosis. Besides, the merremia yunnanensis extract can obviously improve the blood flow states of mouse auricle capillaries, can significantly expand the arteriole diameters of the mouse auriclecapillaries and has the effect of improving microcirculation.

Description

technical field [0001] The invention relates to the application of a natural plant extract in pharmacy, in particular to the new application of the Baiyun melon extract in the field of pharmacy. Background technique [0002] Baiyun melon, also known as blue soil melon, is the root tuber of Convolvulaceae blue flower soil melon (Merremia yunnanensis), which is a unique plant in China. Baiyun melon is distributed in Yunnan, Sichuan and other places in mainland China. It grows in areas with an altitude of 1,400 meters to 3,000 meters. It is generally born in shrubs, hillside grasses, and grassy slopes. The roots are dug in autumn and winter, and the soil is removed and sliced. dry. This product was first recorded in "Southern Yunnan Materia Medica", which says: "Baiyun melon is sweet and non-toxic. There is water near the Jinsha River when it is raw. The stem is very hard. Green and light black leaves. Purple flowers. Melon under the root, eaten raw Not hungry.". Baiyun melo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/39A61P9/10A61P25/00
CPCA61K36/39A61K2236/331A61K2236/333
Inventor 万近福符德欢赵春梅周培军杨顺丽苏梅袁明睿何维颖梅双喜
Owner YUNNAN INST OF MATERIA MEDICA
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