A kind of preparation method of lath octacalcium phosphate fiber

An octacalcium phosphate fiber and lath-shaped technology is applied in the field of preparation of lath-shaped octacalcium phosphate fibers, and can solve the problem that it is difficult to obtain OCP, it is difficult to control the phase composition and morphology of the product, and it is difficult to obtain lath-shaped OCP fibers. problem, to achieve the effect of uniform morphology, single phase, and high synthesis yield.

Active Publication Date: 2021-02-19
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, OCP fibers are often prepared by the hydrolysis reaction of calcium hydrogen phosphate dihydrate (DCPD) and α-tricalcium phosphate (α-TCP), but it is difficult to obtain OCP in a single phase; the synthesis temperature, It is also difficult to control the phase composition and morphology of the product if the initial pH value is used to study the synthesis of OCP, and it is necessary to use the layering phenomenon of OCP and calcium hydrogen phosphate in the solution to extract relatively pure fibrous OCP.
Therefore, there are still many problems in the synthesis of OCP particles or fibers with a single phase composition, and it is more difficult to obtain lath-shaped OCP fibers.

Method used

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  • A kind of preparation method of lath octacalcium phosphate fiber
  • A kind of preparation method of lath octacalcium phosphate fiber
  • A kind of preparation method of lath octacalcium phosphate fiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Take an appropriate amount of calcium nitrate tetrahydrate and ammonium dihydrogen phosphate, and prepare respectively a calcium-containing solution containing 0.5mol / L and a phosphorus-containing solution containing 0.3mol / L;

[0031] (2) Ca / P is prepared as 1.67 mixed solution with above-mentioned solution, wherein the concentration of calcium ion is 0.1mol / L;

[0032] (3) In the configured calcium-phosphorus solution, add dropwise 1mol / L nitric acid solution and ammonia water with a volume ratio of 1:1, and adjust the initial pH=3.0 of the calcium-phosphorus solution under magnetic stirring conditions;

[0033] (4) Add urea and acetamide (1:1 equivalent concentration) containing 1mol / L to the above-mentioned prepared solution, and stir evenly until the urea and acetamide are completely dissolved;

[0034] (5) Pour the prepared calcium-phosphorus mixed solution into the synthesis container, and place it in a constant temperature water bath device with a water temp...

Embodiment 2

[0040] (1) Take an appropriate amount of calcium nitrate tetrahydrate and ammonium dihydrogen phosphate, and prepare respectively a calcium-containing solution containing 0.5mol / L and a phosphorus-containing solution containing 0.3mol / L;

[0041] (2) Ca / P is prepared as 1.67 mixed solution with above-mentioned solution, wherein the concentration of calcium ion is 0.1mol / L;

[0042] (3) In the configured calcium-phosphorus solution, add dropwise 1mol / L nitric acid solution and ammonia water with a volume ratio of 1:1, and adjust the initial pH=3.0 of the calcium-phosphorus solution under magnetic stirring conditions;

[0043] (4) Add urea and acetamide (1:1 equivalent concentration) containing 1mol / L to the above-mentioned prepared solution, and stir evenly until the urea and acetamide are completely dissolved;

[0044] (5) Pour the prepared calcium-phosphorus mixed solution into a synthesis container, and place it in a constant temperature water bath device with a water temper...

Embodiment 3

[0048] (1) Take an appropriate amount of calcium nitrate tetrahydrate and ammonium dihydrogen phosphate, and prepare respectively a calcium-containing solution containing 0.5mol / L and a phosphorus-containing solution containing 0.3mol / L;

[0049] (2) prepare Ca / P as 2 mixed solution with above-mentioned solution, wherein the concentration of calcium ion is 0.3mol / L;

[0050] (3) In the configured calcium-phosphorus solution, add dropwise 1mol / L nitric acid solution and ammonia water with a volume ratio of 1:1, and adjust the initial pH=3.0 of the calcium-phosphorus solution under magnetic stirring conditions;

[0051] (4) Add urea and acetamide (1:1 equivalent concentration) containing 1mol / L to the above-mentioned prepared solution, and stir evenly until the urea and acetamide are completely dissolved;

[0052] (5) Pour the prepared calcium-phosphorus mixed solution into the synthesis container, and place it in a constant temperature water bath device with a water temperature...

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Abstract

The invention provides a method for preparing lath-shaped octacalcium phosphate fiber. The main raw materials used are calcium nitrate tetrahydrate and ammonium dihydrogen phosphate. Nitric acid and ammonia water are selected to adjust the initial pH value of the calcium-phosphorus solution, and urea and acetamide are used as the preparation method. Additives are used to adjust the pH of the synthesis solution. The initial Ca / P ratio of the synthesis solution, the concentration of additives, the temperature and time of the synthesis system have a direct impact on the phase composition of the synthesis sample, the length and aspect ratio of the OCP fibers in the sample. Lath-shaped OCP single crystal fibers with a length of 20-50 μm and an aspect ratio of 4-20 can be prepared by controlling the synthesis conditions, and the synthesized product has a single phase composition, uniform appearance, and no agglomeration. The invention has wide sources of raw materials, simple preparation process and equipment, convenient operation, high production efficiency and uniform product phase.

Description

technical field [0001] The invention belongs to the technical field of preparation of bioceramic materials, and in particular relates to a method for preparing lath-shaped octacalcium phosphate fibers. Background technique [0002] Bioactive ceramic materials have good biocompatibility and bioactivity, and can form a firm bond with bone tissue, but their brittle characteristics severely restrict the application of such materials in the repair or replacement of biological hard tissues. In recent years, although the research on bioactive glass fiber and hydroxyapatite fiber reinforced bioceramics and polymer composites has attracted attention, these materials still lack corresponding bio-osteoinductive and biodegradable properties. [0003] Octacalcium phosphate (Ca 8 (HPO 4 ) 2 (PO 4 ) 4 ·5H 2 O, referred to as OCP), has a mineral composition and structure similar to that of vertebrate hard tissues, such as bones and teeth, and hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B35/447C04B35/622D01F9/08
CPCC04B35/447C04B35/62231D01F9/08
Inventor 张宏泉文进祁玲玲
Owner WUHAN UNIV OF TECH
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