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A kind of preparation method of antibacterial coating based on polyimidazolium salt

A technology of polyimidazolium salt and antibacterial coating is applied in the field of preparation of antibacterial coating, which can solve problems such as endangering life safety, bacterial infection, loss of patients, etc., and achieve good sterilization ability, good biocompatibility, and controllable conditions. Effect

Active Publication Date: 2020-12-04
CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it also has serious challenges in clinical use, such as the problem of bacterial infection caused
Bacterial infection problems lead to nosocomial infections, causing great losses to patients, and even causing disabilities and endangering life safety

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] In the present embodiment, the preparation method of the antibacterial coating based on polyimidazolium salt, concrete steps are as follows:

[0018] (1) Taking the silica gel sheet as an example, the surface area selected here is 0.25cm 2 The substrate pretreatment steps: first, wash with water and absolute ethanol in turn, repeat 3 times and then dry in a 30°C oven for 24 hours; second step, prepare solution A: 1g of epoxy resin and 9mL of Mix dichloromethane, put in the silica gel sheet, soak it, then take it out and dry it in an oven at 30°C for 30 minutes, repeat the above steps twice; finally, prepare solution B: dissolve 1g of azobisisobutyronitrile in 9ml of acetone, mix A, Mix B solutions (A:B=1:0.5), put the silica gel sheet into the mixed solution, soak it, take it out and dry it in an oven at 30°C for 24 hours, and produce a coating with an initiator on the surface of the silica gel sheet.

[0019] (2) Select acrylic acid for use, and prepare the transition...

Embodiment 2

[0022] In the present embodiment, the preparation method of the antibacterial coating based on polyimidazolium salt, concrete steps are as follows:

[0023] (1) Taking the silica gel sheet as an example, the surface area selected here is 0.25cm 2 The substrate pretreatment steps: first, wash with water and absolute ethanol in turn, repeat 3 times and then dry in a 30°C oven for 24 hours; second step, prepare solution A: 1g of epoxy resin and 9mL of Mix dichloromethane, put in the silica gel sheet, soak it, then take it out and dry it in an oven at 30°C for 30 minutes, repeat the above steps twice; finally, prepare solution B: dissolve 1g of azobisisobutyronitrile in 9ml of acetone, mix A, Mix B solutions (A:B=1:0.5), put the silica gel sheet into the mixed solution, soak it, take it out and dry it in an oven at 30°C for 24 hours, and produce a coating with an initiator on the surface of the silica gel sheet.

[0024] (2) Select acrylic acid for use, and prepare the transition...

Embodiment 3

[0027] In the present embodiment, the preparation method of the antibacterial coating based on polyimidazolium salt, concrete steps are as follows:

[0028] (1) Taking the glass sheet as an example, the surface area selected here is 0.25cm 2 The substrate pretreatment steps: first, wash with water and absolute ethanol in turn, repeat 3 times and then dry in a 30°C oven for 24 hours; second step, prepare solution A: 1g of epoxy resin and 9mL of Mix the dichloromethane, put the glass piece in, soak it, then take it out and dry it in a 30°C oven for 30 minutes, repeat the above steps twice; finally, prepare solution B: dissolve 1g of azobisisobutyronitrile in 9ml of acetone, mix A, Mix B solutions (A:B=1:0.5), put the glass piece into the mixed solution, soak it, take it out and dry it in a 30°C oven for 24 hours, and produce a coating with an initiator on the surface of the glass piece.

[0029] (2) select acrylic acid for use, and prepare the transition coating and include the...

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Abstract

The invention relates to the field of the function coating, and specifically relates to a preparation method of antibacterial coating based on polyimidazole salt. The preparation method comprises thefollowing steps: (1) pretreating substrate; (2) preparing transition coating; and (3) preparing polyimidazole salt coating. The method disclosed by the invention is simple in operation and controllable in condition; the formed antibacterial coating has relatively good adhesive resistance and bactericidal ability, and the antibacterial effect is obvious.

Description

technical field [0001] The invention relates to the field of functional coatings, in particular to a method for preparing an antibacterial coating based on polyimidazolium salt. Background technique [0002] Biomedical materials play an important role in diagnosis, treatment, organ repair and regeneration, and prolonging the life of patients. However, it also has serious challenges in clinical use, such as the problem of bacterial infection caused. Bacterial infection problems lead to nosocomial infections, causing heavy losses to patients, and even disability and life-threatening. [0003] Bacterial infection first adheres to the surface of the material, followed by bacterial aggregation. After reaching a certain concentration, extracellular matrix proteins are secreted to form a biofilm. The biofilm can protect bacteria from escaping host immunity and the killing of antibacterial drugs, weakening the ineffectiveness of antibacterial drugs on cells in the membrane, which ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/16C08F120/06C08G73/06C09D163/00C09D133/02C09D179/04C09D5/14A61L29/08A61L29/14
CPCA61L29/08A61L29/14A61L2420/02C08F120/06C08G73/06C08J7/16C08J2383/04C08J2433/02C08J2463/00C08J2479/04C09D5/14C09D133/02C09D163/00C09D179/04C08L79/04
Inventor 刘博梁敬时张霏霏周超伍明
Owner CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY