Bacteriostatic agent with branched polyamino acid and application

A technology of polyamino acid and bacteriostatic agent, applied in the direction of application, bactericide, antifungal agent, etc., to achieve the effect of simple preparation process, low cost, and easy-to-obtain materials

Inactive Publication Date: 2018-07-13
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of branched polyamino acid in the antibacterial field has not been reported so far

Method used

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  • Bacteriostatic agent with branched polyamino acid and application
  • Bacteriostatic agent with branched polyamino acid and application
  • Bacteriostatic agent with branched polyamino acid and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Add 80 grams of arginine and 20 grams of alanine into a 500-mL round-bottomed flask, connect the water separator, pump nitrogen three times, each time for more than 10 minutes, and finally keep the nitrogen atmosphere, stir and heat the reaction at 180°C for 4 hours, stop After heating, the reaction system was cooled to room temperature, and the polymer was dissolved in methanol and settled in ether to obtain 78.7 grams of hyperbranched polyamino acids.

Embodiment 2

[0064] Add 50 grams of ornithine, 50 grams of leucine and 10 mg of scandium trifluoromethanesulfonate into a 500 mL round bottom flask, connect the water diversion device, pump nitrogen three times, each time more than 10 minutes, and finally maintain the nitrogen atmosphere, Stir and heat at 180°C for 4 hours, stop heating, dissolve the polymer in methanol and settle in ether to obtain 81.5 g of hyperbranched polyamino acid.

Embodiment 3

[0066] Add 91.32 grams of lysine hydrochloride, 28.05 grams of KOH and 20 grams of alanine into a 500mL round bottom flask, connect the water separator, pump nitrogen three times, each time more than 10 minutes, and finally maintain nitrogen atmosphere, 180 ° C The reaction was heated under stirring for 4 hours, the heating was stopped, and then the reaction system was cooled to room temperature, and the polymer was dissolved in methanol and settled in ether to obtain 75.2 grams of branched polyamino acids.

[0067] The 1H NMR spectrum of the synthesized branched polyamino acid is as follows: figure 1 shown.

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Abstract

The invention provides a bacteriostatic agent with branched polyamino acid. The bacteriostatic agent comprises branched polyamino acid, wherein the branched polyamino acid is obtained by copolymerization of two or more than two types of amino acid units; the amino acid units have structural formulas shown in a formula I. The raw materials used by the invention are various amino acids, are naturalbiological materials without toxicity and side effects respectively, is a green and environment-friendly novel bacteriostatic agent and is easily accepted by a user. Due to a branched structure of thepolyamino acid, the bacteriostatic agent can be further modified due to a large amount of active function groups, has good biocompatibility, can tear bacterial membranes to cause death of bacteria, and can not generate drug resistance after long-time use. The formula I is shown in the description.

Description

technical field [0001] The invention relates to the technical field of antibacterial agents, in particular to a branched polyamino acid antibacterial agent and its application. Background technique [0002] The invention of antibiotics has saved the lives of hundreds of millions of people and saved human beings from the pain of bacterial infection. It can be said to be a revolution in medicine. However, with the abuse of small molecule antibiotics, coupled with the short life cycle of bacteria and the characteristics of horizontal gene transfer, various drug-resistant bacteria have emerged. The spread of pathogenic bacteria is a serious threat to people's normal life. If left unchecked, superbugs could kill around 10 million people a year by 2050, according to a new study. Drug-resistant bacteria has become a hot issue of widespread concern around the world, which is related to global human health, economic development and social stability. [0003] Compared with small mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/10A01N37/46A01N47/44A61K31/785A61K31/787A01P1/00A01P3/00A61P31/04A61P31/10A61K8/88A61Q11/00A61Q19/10A61Q17/00A61P31/02
CPCA61Q11/00A61Q17/005A61Q19/10A01N37/46A01N47/44A61K8/88A61K31/785A61K31/787C08G69/10A61P31/04A61P31/10A61P31/02
Inventor 季生象刘骁韩苗苗刘亚栋郭建伟
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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