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Anti-leakage cold storage agent and preparation method thereof

A cold storage agent and anti-leakage technology, which is applied in the direction of chemical instruments and methods, reagents, educts, etc., can solve the problems of contaminating pharmaceutical biological products, easy leakage, and potential safety hazards of phase-change cold storage materials, etc., and achieves convenient preparation process. simple effect

Active Publication Date: 2018-07-13
ANHUI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, people ignore its important defect in the market at present: its own liquid state is easy to leak and contaminate pharmaceutical biological products
Therefore, in the process of circulation, this kind of phase change cold storage material has great potential safety hazards and poses a serious threat to people's property and life.
However, there are few reports on how to avoid the easy leakage of such materials

Method used

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  • Anti-leakage cold storage agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) the mass fraction is 1% K 2 HPO 4 The aqueous solution is added dropwise to an aqueous solution of polyethylene glycol (number average molecular weight: 600) with a mass fraction of 1%, and stirred and mixed at room temperature to obtain a solution A. The K 2 HPO 4 The volume ratio of polyethylene glycol solution is 1:100.

[0021] (2) Slowly add n-tetradecane dropwise to solution A, and stir at room temperature for 1 h to obtain solution B. The mass ratio of n-tetradecane in solution B to solution A is 90:1.

[0022] (3) At room temperature, mix sodium carboxymethyl cellulose aqueous solution (1% by mass fraction) and sodium lauryl sulfate (1% by mass fraction) at a volume ratio of 1:1, and stir for 30 minutes to obtain solution C.

[0023] (4) Add solution C dropwise to solution B, and continue stirring at room temperature for 1 hour to obtain a leak-proof cool storage agent. The volume ratio of solution C and solution B is 1:0.8.

[0024] The cold storage ...

Embodiment 2

[0026] (1) the mass fraction is 1% K 2 HPO 4 The aqueous solution is added dropwise to an aqueous solution of polyethylene glycol (number average molecular weight: 10,000) with a mass fraction of 1%, and stirred and mixed at room temperature to obtain a solution A. The K 2 HPO 4 The volume ratio of polyethylene glycol solution is 1:100.

[0027] (2) Slowly add n-tetradecane dropwise to solution A, and stir at room temperature for 1 h to obtain solution B. The mass ratio of n-tetradecane in solution B to solution A is 90:1.

[0028] (3) At room temperature, mix sodium carboxymethyl cellulose aqueous solution (2% by mass fraction) and sodium lauryl sulfate (2.5% by mass fraction) at a volume ratio of 2:1, and stir for 30 minutes to obtain solution C.

[0029] (4) Add solution C dropwise to solution B, and continue stirring at room temperature for 1 hour to obtain a leak-proof cool storage agent. The volume ratio of solution C and solution B is 1:2.6.

[0030] The cold sto...

Embodiment 3

[0032] (1) the mass fraction is 1% K 2 HPO 4 The aqueous solution is added dropwise to an aqueous solution of polyethylene glycol (number-average molecular weight: 8000) with a mass fraction of 1%, and stirred and mixed at room temperature to obtain a solution A. The K 2 HPO 4 The volume ratio of polyethylene glycol solution is 1:100.

[0033] (2) Slowly add n-tetradecane dropwise to solution A, and stir at room temperature for 1 h to obtain solution B. The mass ratio of n-tetradecane in solution B to solution A is 90:1.

[0034] (3) At room temperature, mix sodium carboxymethyl cellulose aqueous solution (1.6% by mass fraction) and sodium lauryl sulfate (2% by mass fraction) at a volume ratio of 1:1, and stir for 30 minutes to obtain solution C.

[0035] (4) Add solution C dropwise to solution B, and continue stirring at room temperature for 1 hour to obtain a leak-proof cool storage agent. The volume ratio of solution C and solution B is 1:0.8.

[0036] The cold stora...

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Abstract

The invention provides an anti-leakage cold storage agent and a preparation method thereof, belonging to the technical field of phase-change cold storage materials. The anti-leakage cold storage agentis jelly-like, does not easily flow, is leak-proof, and has a phase-change temperature of 5.8-6.6 DEG C and phase change latent heat of about 152-168 KJ / Kg. The specific preparation process comprisesthe following steps: firstly, mixing a K2HPO4 aqueous solution with a polyethylene glycol aqueous solution, and then slowly dropwise adding n-tetradecane so as to form a mixed solution; finally, adding a mixed solution of a sodium carboxymethylcellulose aqueous solution and sodium dodecyl sulfate, and stirring to obtain the anti-leakage cold storage agent. The anti-leakage cold storage agent provided by the invention is convenient in preparation process and simple in technology, thus being suitable for large-scale preparation; furthermore, the phase change temperature of the cold storage agent is within a range of 5.8-6.6 DEG C, and the cold storage agent has the phase change latent heat of about 152-168 KJ / Kg, so that the cold storage agent can guarantee transported objects to be in a range of 2-8 DEG C for a certain period of time in a process of circulation on the basis of preventing leakage; therefore, the cold storage agent is suitable for the cold chain transportation industry of medicines such as vaccines.

Description

technical field [0001] The invention belongs to the technical field of phase-change cold storage materials, and in particular relates to a leak-proof cold storage agent and a preparation method thereof. Background technique [0002] In recent years, with the rapid development of the pharmaceutical industry, especially after the Shandong vaccine incident, how to ensure the quality of vaccines and other medicines in the circulation process of storage, transportation, transfer, and distribution has become a key issue in the field of pharmaceutical cold chain. In the circulation process, using phase change cold storage materials and using refrigerators has always been a conventional method in the pharmaceutical cold chain industry, and phase change cold storage materials are the core of this method (Tao Wenbo et al., Journal of Refrigeration, Organic phase change cold storage materials. Research Advances, 2016, 37, 52-59). [0003] Vaccines and other medicines are biological pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K5/06
CPCC09K5/066Y02E60/14Y02P20/141
Inventor 夏友谊刘小辉刘宁
Owner ANHUI UNIVERSITY OF TECHNOLOGY
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