Degradable skin expander

A skin expansion and balloon technology, which is used in medical science, surgery, diagnosis, etc.

Active Publication Date: 2018-07-31
SUZHOU NANOCRYSTAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, no absorbable and biodegradable skin expander has been launched. With the upgrading of consumption, people's requirements for the aesthetics of skin repair are increasing. The launch of this product will definitely bring patients a better consumer experience and is expected to replace the traditional The market of non-absorbable skin expanders, bringing good social and economic benefits, has a bright prospect

Method used

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  • Degradable skin expander
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] S1-1 Dissolve degradable polyurethane (PU with propylene glycol as the initiator, random copolymerization of PDO and GA as the soft segment and lysine diisocyanate as the hard segment, with a number average molecular weight of 50,000-80,000) in chloroform solution , made into a 12-18% solution, and spun into an absorbable medical membrane with a pore size of 10-150 μm and a thickness of 0.1-0.4 mm by electrospinning technology;

[0042] S1-2 Evenly coating sodium hyaluronate gel or polyamino acid gel on the absorbable medical film obtained in step S1-1, drying or air-drying;

[0043] S1-3 Degradable polyurethane is dissolved in chloroform solution, and a breathable and impermeable film is made by solvent evaporation method. The membrane obtained in step S1-2 is spread on the breathable and impermeable surface, and after folding, the four sides are melted to form a dilator shape , which forms figure 1 A skin expander with tissue-inducing functionality is shown.

Embodiment 2

[0045] S2-1 Dissolve degradable polyurethane (with PEG400 as the initiator, PDO and LA randomly copolymerized as soft segment, lysine diisocyanate as hard segment PU, number average molecular weight 80,000-100,000) in chloroform solution , made into a 10-15% solution, and spun into a membrane with a pore size of 10-150 μm and a thickness of 0.05-0.1 mm by electrospinning technology, and evenly coated with a layer of polylysine PU (first formulated with 1% hydrogel glue for use), that is, the absorbable medical film;

[0046] S2-2 The degradable polyurethane is dissolved in chloroform solution, and the air-permeable and water-impermeable film is made by the solvent evaporation method. The absorbable medical film obtained in step S2-1 is spread on the air-permeable and water-impermeable film, and the four sides are melted after folding. dilator shape, that forms figure 1 A skin expander with tissue-inducing functionality is shown.

Embodiment 3

[0048] S3-1 Make PLGA (number average molecular weight 50,000, LA:GA=6:4) into 15-20% chloroform solution, and use electrospinning technology to spin it into a product with a pore size of 100-300μm and a thickness of 0.2-0.3mm film, made of absorbable medical film;

[0049] S3-2 Dissolve degradable polyurethane (PU with PEG200 as the initiator, random copolymerization of CL and LA as the soft segment and lysine diisocyanate as the hard segment, with a number average molecular weight of 60,000-80,000) in chloroform solution , made into a 10-15% solution, and made into a breathable and water-impermeable film by solvent evaporation, and the absorbable medical film obtained in step S3-1 was spread on the air-permeable and water-impermeable film, folded and melted on all sides to form a dilator shape , which forms figure 1 A skin expander with tissue-inducing functionality is shown.

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Abstract

The invention discloses a degradable skin expander. The skin expander comprises a bag which has the tissue regeneration inducing function and is made of an absorbable medical membrane; the absorbablemedical membrane is mainly made from degradable polyurethane, in the skin opening process, cells are promoted to crawl and grow through a membrane support to form incremental skin, and the skin expander can be used for skin grafting and scar repair. The skin expander has the advantages of being fast in skin growth, low in infection rate and high in wound healing speed, and no second operation is needed for removing the skin expander.

Description

technical field [0001] The invention belongs to the technical field of medical devices used in dermatology, and in particular relates to a skin expander with tissue-inducing function that does not require secondary operations to be taken out. The skin expander with tissue-inducing function includes an absorbable medical diaphragm, In the process of stretching, it promotes the cells to adsorb and crawl on the absorbable medical membrane support to form incremental skin, which can be used for skin transplantation and scar repair. The advantages of the present invention are that the skin grows fast, the infection rate is low, and no two The skin expander was removed in the first operation, and the wound healed quickly. Background technique [0002] Skin dilatation is a technique that expands the covered skin area by implanting a dilator deep in the skin and gradually expanding it. Skin expansion provides additional skin augmentation to repair and replace adjacent scars or othe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B90/00A61L31/06A61L31/14A61L31/16
CPCA61L31/06A61L31/14A61L31/146A61L31/148A61L31/16A61L2300/406A61L2300/41A61L2300/606A61B90/02
Inventor 张文芳
Owner SUZHOU NANOCRYSTAL PHARMA
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