Medical dressing and its preparation method and application

A medical, mass percentage technology, applied in the field of biological materials and medical supplies, can solve the problems of aggravated inflammatory reaction at the wound site, uncontrolled material acidity and alkalinity, wound irritation, etc., to promote healing and analgesic scar formation, excellent moisture absorption and moisturizing Performance, effects of balancing inflammation

Inactive Publication Date: 2008-10-15
WUHAN RUIER BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these dressings have better effects, there are deficiencies, such as the low strength of alginate dressings, and the exchange of sodium and calcium ions between the wound and the dressing will easily cause the dressing to dissolve and have no antibacterial properties; proteins such as gelatin have poor strength and no antibacterial properties. In addition to the deficiency of antibacterial activity, it also has certain immunogenicity and the risk of spreading viruses due to its origin from heterogeneous mammals
Although it has good antibacterial properties, too high acidity (pH 3-5) can cause serious irritation to the wound, causing discomfort to the patient and affecting wound healing; in addition, the ability of shell polysaccharides and chitin to absorb and moisturize is also limited, and it is difficult to Meet the requirements of "wet therapy"
Wu Yiguang (CN 1500525A) introduced carboxymethyl groups into chitosan to obtain quasi-cationic chitin derivatives, but because of its low degr

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 2.86 million molecular weight, deacetylation degree of 15%, carboxymethylation degree of 0.7, 6-hydroxyl substitution degree of 0.6 carboxymethyl chitin 25g is dissolved in 4975ml of distilled water to obtain a solution with a mass percentage of 0.5%; the molecular weight is 480,000, the degree of deacetylation is 15%, and the degree of substitution is 100 grams of hydroxyethyl chitin of 0.5, which is dissolved in 3900ml distilled water to obtain a solution with a mass percentage of 4%; the molecular weight is 1500, the degree of deacetylation is 98%, and the carboxylated 50 grams of carboxymethyl chitosan with a degree of methylation of 1.45 and a degree of substitution of 6-hydroxyl of 0.97 was dissolved in 450 ml of distilled water to obtain a solution with a mass percentage of 10%. After mixing the three solutions evenly at room temperature, add 160ml of glycerin and 100ml of isopropanol, and continue mixing evenly and degassing under reduced pressure to obtain ...

Embodiment 2

[0019] Get molecular weight 1,890,000, deacetylation degree 70%, carboxymethylation degree is 0.65, the carboxymethyl chitosan 50g of the degree of substitution of 6 hydroxyl groups 0.6, be dissolved in 4950ml distilled water and obtain the solution that mass percent is 1%; Take 100 grams of hydroxypropyl chitin with a molecular weight of 450,000, a degree of substitution of 0.8, and a degree of deacetylation of 15% and a molecular weight of 30,000, a degree of deacetylation of 5%, a degree of carboxymethylation of 1.45, and the substitution of the 6-hydroxyl group 50 g of carboxymethyl chitin with a density of 0.95 was dissolved in 2350 ml of distilled water to obtain a solution with a mass percentage of 6%. After the above solution was mixed uniformly at room temperature, 200 ml of glycerin and 100 g of PEG400 were added, and the mixture was continued to obtain a hydrocolloid dressing with a pH value of 6.8.

[0020] The above hydrocolloid dressing is cast or coated in a sta...

Embodiment 3

[0024] Take molecular weight is 1.92 million, deacetylation degree is 52% water-soluble chitin 50 grams, be dissolved in 4950ml distilled water and obtain the solution that mass percent is 1%; Get molecular weight 450,000, deacetylation degree 85%, carboxymethylation degree is 1.1, 100 g of carboxymethyl chitosan with a degree of substitution of 6 hydroxyl groups of 0.85 is dissolved in 1900 ml of distilled water to obtain a solution with a mass percentage of 5%; take a hydroxyethyl group with a molecular weight of 600,000, a degree of deacetylation of 85%, and a degree of substitution of 0.9 Chitosan 50g was dissolved in 950ml distilled water to obtain a solution of 5% by mass; after the above solution was mixed uniformly at room temperature, 600ml of glycerin and 100ml of butanediol were added, and the mixture was continued to obtain a hydrocolloid dressing with a pH of 6.2.

[0025] The above-mentioned hydrocolloid dressing is cast or coated into a film in a stainless steel ...

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PUM

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Abstract

The invention discloses a dressing for medical use, a preparation method and an application thereof. The dressing comprises one or more of chitin derivative, chitosan derivative or water soluble chitin 1-100 wt%, water 0-99 wt%, and filler 0-60 wt%. The preparation method comprises respectively dissolving one or more of the chitin derivative, chitosan derivative or water soluble chitin into water to obtain 0.5-10 wt% aqueous solution, mixing intensively, adding 0-15 wt% filler, mixing intensively, vacuum de-bubbling to obtain hydrocolloid dressing, and subsequently obtaining filmy dressing, spongeous dressing or non-woven fabric dressing. The preparation method has simple process, and can be used for restoring skin wound such as operative incision in clinic, skin graft region, burn, scald, ulcer or bedsore.

Description

technical field [0001] The invention relates to a medical dressing and its preparation method and application, belonging to the field of medical supplies and also the field of biological materials. Background technique [0002] Medical dressings are materials used to cover wounds. Their primary function is to control wound exudate and protect the wound from contamination by bacteria and dust particles. Wounds that heal better after covering them have been documented as far back as 4,500 years ago. Over the millennia, there have been many different types of dressings, but wound dressings have long been designed on the premise of keeping the wound dry . This concept has undergone a fundamental change since the 1960s. In 1962, the British Winter found that wounds healed faster in a wet state than in a dry state. Since then, "wet therapy" has gradually become the main theoretical basis for the design of new medical dressings. Since the 1980s, western developed countries have...

Claims

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Application Information

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IPC IPC(8): A61L15/28
Inventor 杨建红吴斌
Owner WUHAN RUIER BIOTECH
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