Medical dressing and its preparation method and application

Abstract

The invention discloses a dressing for medical use, a preparation method and an application thereof. The dressing comprises one or more of chitin derivative, chitosan derivative or water soluble chitin 1-100 wt%, water 0-99 wt%, and filler 0-60 wt%. The preparation method comprises respectively dissolving one or more of the chitin derivative, chitosan derivative or water soluble chitin into water to obtain 0.5-10 wt% aqueous solution, mixing intensively, adding 0-15 wt% filler, mixing intensively, vacuum de-bubbling to obtain hydrocolloid dressing, and subsequently obtaining filmy dressing, spongeous dressing or non-woven fabric dressing. The preparation method has simple process, and can be used for restoring skin wound such as operative incision in clinic, skin graft region, burn, scald, ulcer or bedsore.

Description

technical field [0001] The invention relates to a medical dressing and its preparation method and application, belonging to the field of medical supplies and also the field of biological materials. Background technique [0002] Medical dressings are materials used to cover wounds. Their primary function is to control wound exudate and protect the wound from contamination by bacteria and dust particles. Wounds that heal better after covering them have been documented as far back as 4,500 years ago. Over the millennia, there have been many different types of dressings, but wound dressings have long been designed on the premise of keeping the wound dry . This concept has undergone a fundamental change since the 1960s. In 1962, the British Winter found that wounds healed faster in a wet state than in a dry state. Since then, "wet therapy" has gradually become the main theoretical basis for the design of new medical dressings. Since the 1980s, western developed countries have...

AI Technical Summary

Problems solved by technology

Although these dressings have better effects, there are deficiencies, such as the low strength of alginate dressings, and the exchange of sodium and calcium ions between the wound and the dressing will easily cause the dressing to dissolve and have no antibacterial properties; proteins such as gelatin have poor strength and no antibacterial properties. In addition to the deficiency of antibacterial activity, it also has certain immunogenicity and the risk of spreading viruses due to its origin from heterogeneous mammals

Although it has good antibacterial properties, too high acidity (pH 3-5) can cause serious irritation to the wound, causing discomfort to the patient and affecting wound healing; in addition, the ability of shell polysaccharides and chitin to absorb and moisturize is also limited, and it is difficult to Meet the requirements of "wet therapy"

Wu Yiguang (CN 1500525A) introduced carboxymethyl groups into chitosan to obtain quasi-cationic chitin derivatives, but because of its low degree of carboxymethylation, it can only be dissolved in acidic solutions, and the dressings made by it have greater irritation

In recent years people such as Liu Wanshun (CN1813786A, CN101049513A, CN101053669A, CN1887358A), Wu Qingji et al. (CN1833731A, CN1833732A) also adopt carboxymethyl chitosan or chitin to prepare type dressings such as hydrogel, fiber, sponge, but all do not have right The structure of carboxymethyl chitin or chitosan material such as molecular weight, degree of deacetylation and degree of carboxymethylation is controlled, and the acidity and alkalinity of the material are not controlled, so the ideal effect cannot be achieved. Amino groups can aggravate the inflammatory response at the wound site, too high or too low acidity can irritate the wound, and the molecular weight and degree of substitution can have a serious impact on the moisture retention and healing speed of the wound site

Thus these technologies have limited the application of chitin and chitosan in wound repair