Carbon ion radiotherapy method established based on individualized relative biological effectiveness of patient-derived tumor tissue xenograft transplantation model

Abstract

The invention discloses a carbon ion radiotherapy method established based on an individualized tumor tissue relative biological effectiveness determined by a patient-derived tumor tissue xenograft transplantation model. For an individual patient, the values of the individualized tumor tissue relative biological effectiveness are obtained by the patient-derived tumor tissue xenograft transplantation animal model, and a process and method of the carbon ion radiotherapy are established. According to the invention, a precise individualized treatment scheme of cancer patients can be given, due tothe individualized precise medical treatment, the treatment accuracy can be improved, and the side effects caused by the treatment of a patient can be effectively reduced, so that the damage to the patient can be reduced, and the medical quality can be well ensured, the treatment effect is improved, the patient is benefited, and the device is easier to popularize and use. According to the invention, the indirect economic loss caused by the disease due to treatment can be reduced, more targeted individualized and accurate carbon ion treatment is provided for the patient through a prediction means, and unnecessary recovery drug cost is avoided.

Description

technical field [0001] The present invention belongs to the technical field of medical systems, and in particular relates to an individualized relative biological effect (Relative Biological Effectiveness - RBE) based on a patient-derived xenograft model (Patient-derived xenograft model, PDX model) to Established carbon ion precision radiation therapy. Background technique [0002] Carbon ion beam radiation therapy is a cancer treatment technology that uses high-energy carbon ion beams to penetrate the patient's body and deposit therapeutic doses into the target tumor area to kill cancer cells and avoid damage to normal tissues. A carbon ion beam therapy system usually includes an ion source system, an entry orbit, an acceleration system, a beam transmission system, several treatment delivery systems and several treatment planning systems. The carbon ions generated from the ion source system flow into the acceleration system through the entry orbit, and are synchronized. Th...

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Problems solved by technology

The application of carbon ion beam therapy system to treat patients involves a series of complicated processes and decisions, which require the close cooperation of various clinical departments. At present, there is no effective process and method for this treatment system in my country. Based on this, a high-energy carbon therapy system is designed. The process and method of ion beam precision therapy system diagnosis and treatment are still necessary

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