Carbon ion radiotherapy method established based on individualized relative biological effectiveness of patient-derived tumor tissue xenograft transplantation model

A technology of tumor tissue and xenotransplantation, applied in radiation therapy, X-ray/γ-ray/particle irradiation therapy, treatment, etc., to reduce medical expenses, ensure medical quality, and improve accuracy

Inactive Publication Date: 2018-07-31
上海市质子重离子医院有限公司
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of carbon ion beam therapy system to treat patients involves a series of complicated processes and decisions, which require the close cooperation of various clinical departments. At present, there is no effective

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Carbon ion radiotherapy method established based on individualized relative biological effectiveness of patient-derived tumor tissue xenograft transplantation model
  • Carbon ion radiotherapy method established based on individualized relative biological effectiveness of patient-derived tumor tissue xenograft transplantation model
  • Carbon ion radiotherapy method established based on individualized relative biological effectiveness of patient-derived tumor tissue xenograft transplantation model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0019] Such as Figure 1 to Figure 3 As shown, a carbon ion radiotherapy method established based on the individualized relative biological effects of the patient-derived tumor tissue xenograft model, the carbon ion radiotherapy method is aimed at the individual patient, and the PDX model established by the patient's cancer tumor cells is used to Obtain the value of individualized tumor tissue RBE, so as to establish the process and method of carbon ion radiotherapy; obtain the tumor tissue RBE value obtained from the PDX model of preclinical patients according to the factors that comprehensively affect the relative biological effect, and combine the RBE based on The carbon ion beam dose distribution calculation method of radiation dosimetry is applied to the carbon ion beam intensity-modulated radiotherapy planning software system to quickly...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a carbon ion radiotherapy method established based on an individualized tumor tissue relative biological effectiveness determined by a patient-derived tumor tissue xenograft transplantation model. For an individual patient, the values of the individualized tumor tissue relative biological effectiveness are obtained by the patient-derived tumor tissue xenograft transplantation animal model, and a process and method of the carbon ion radiotherapy are established. According to the invention, a precise individualized treatment scheme of cancer patients can be given, due tothe individualized precise medical treatment, the treatment accuracy can be improved, and the side effects caused by the treatment of a patient can be effectively reduced, so that the damage to the patient can be reduced, and the medical quality can be well ensured, the treatment effect is improved, the patient is benefited, and the device is easier to popularize and use. According to the invention, the indirect economic loss caused by the disease due to treatment can be reduced, more targeted individualized and accurate carbon ion treatment is provided for the patient through a prediction means, and unnecessary recovery drug cost is avoided.

Description

technical field [0001] The present invention belongs to the technical field of medical systems, and in particular relates to an individualized relative biological effect (Relative Biological Effectiveness - RBE) based on a patient-derived xenograft model (Patient-derived xenograft model, PDX model) to Established carbon ion precision radiation therapy. Background technique [0002] Carbon ion beam radiation therapy is a cancer treatment technology that uses high-energy carbon ion beams to penetrate the patient's body and deposit therapeutic doses into the target tumor area to kill cancer cells and avoid damage to normal tissues. A carbon ion beam therapy system usually includes an ion source system, an entry orbit, an acceleration system, a beam transmission system, several treatment delivery systems and several treatment planning systems. The carbon ions generated from the ion source system flow into the acceleration system through the entry orbit, and are synchronized. Th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61N5/10G16H50/20
CPCA61N5/1031A61N5/1039A61N5/1071A61N2005/1035A61N2005/1041A61N2005/1087
Inventor 陆嘉德林鹏裕
Owner 上海市质子重离子医院有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap