37 results about "Carbon ion beam" patented technology

An apparatus, method and system for measurement of radiation during or directly following hadron therapy treatment for dose and range verification purposes accomplished through measurement of prompt gamma and other beam-induced radiation. One example includes the measurement of secondary prompt gamma radiation during proton and carbon ion beam irradiation. The measurement can also be made of other beam-induced radiation results. The measurement of gamma radiation or other beam-induced radiation allows for optimization of radiation dose disposition to the target tissue, with improved sparing of surrounding critical structures and normal tissue. Adjustments to a radiation treatment may be made as needed based on actual and measured applied dosages.

Normal tissue complications limit curative broadbeam radiotherapy to tumors including lung cancer. Radiation retinitis causing blindness limits quality of life and long term survival for patients with ocular melanoma. This invention pertains to alternative, normal tissue sparing 100 to 1,000 Gy microbeam radiations with least normal tissue complications and concomitant radio-immunotherapy by innate immune response of epidermis and dermis to low dose radiation with 50 kV X-rays. Total body skin radiation with former airport passenger screening machines with 50 kV X-ray is disclosed. Microbeams are generated without contaminating scatter and neutron radiations from collinear gamma ray and electron beam produced by inverse Compton interaction with high energy laser and electron beam and from proton and carbon ion beams in tissue equivalent cylindrical collimators. Extracorporeal immunotherapy and chemotherapy and apheresis of mutated subcellular particles released into circulation in response to cancer-therapies are by clinical continuous flow ultracentrifugation combined chromatography.

This invention relates to adaptive resistance inhibiting 100 to 10,000 Gy, single fraction proton and carbon ion microbeam and nanobeam radiosurgery, proton spray chemotherapy and proton spray gadolinium and boron neutron capture therapy with least normal tissue toxicity. Secondary neutrons, protons, ions and radiation from the accelerator and the patient specific collimator are removed with tissue equivalent collimator that also generates proton and carbon ion microbeam and nanobeam. Laser interaction with micrometer and nanometer thick metallic and diamond like carbon targets are also used for proton and carbon ion beam generation. Polyenergetic proton beam is spatially separated. Ion beam and Laser ion beam is accelerated in a hybrid RF accelerator. It is split into microbeam and nanobeam. Secondary neutrons, protons and gamma radiation are removed with tissue equivalent collimators that also generate microbeams and nanobeams. Adaptive resistance to cancer treatment is inhibited by dual target radiation, DNA strands break and enzymes inactivation.

Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.

Isotopically-enriched graphene and isotope junctions are epitaxially grown on a catalyst substrate using a focused carbon ion beam technique. The focused carbon ion beam is filtered to pass substantially a single ion species including a single desired carbon isotope. The ion beam and filtering together provide a means to selectively isotopically-enrich the epitaxially-grown graphene from given carbon precursor and to selectively deposit graphene enriched with different carbon isotopes in different regions.

A charged particle cancer therapy system is used to accelerate an anion, such a C−, and to convert the anion to a cation, such as C6+, through use of one or more electron extraction subsystems. A first example of an electron extraction subsystem is a hydrogen gas electron stripping system. A second example of an electron extraction subsystem is a carbon foil electron stripping system. The resultant cation is accelerated in a synchrotron, transported along a beam-line, and targeted to a tumor resulting in ablation of the tumor.

A medical proton heavy ion accelerator comprises ion sources, a low energy injector, a cyclotron and a traveling wave linear accelerator connected in sequence; the ion sources comprise a hydrogen ionsource and a carbon ion source, and can provide hydrogen ions and carbon ions, thus enabling the medical proton heavy ion accelerator to has two radiotherapy modes that include a proton ray mode and aheavy ion ray mode; said two radiotherapy modes are mutually implemented, and can be selected according to real treatment demands; the cyclotron can directly accelerate a hydrogen ion beam or a carbon ion beam from a low energy level to a high energy level, thus providing higher acceleration efficiency and effect; the energy of the proton beam or carbon ion beam emitted by the traveling wave linear accelerator can be adjusted, thus obtaining the proton beam or carbon ion beam of different energy values, satisfying different dosage demands for curing cancers, providing a strong adaptability, and improving the cancer treatment effect.

The invention comprises a charged particle cancer therapy system used to seal a periphery of a tumor, such as through use of a proton or carbon ion beam searing the outer edges of the tumor, which prevents / hinders nutrient delivery to the tumor resultant in stunted growth of the tumor, halted growth of the tumor, and / or starvation / necrosis of the tumor. Optionally, a tumor sealing layer is formed using multiple passes, of a treatment beam of the charged particle cancer therapy system, across a tumor / healthy tissue boundary layer or voxel.

The invention relates to a cordyceps militaris mutant strain for obtaining high-yield cordycepin and application of the cordyceps militaris mutant strain. A heavy carbon ion beam injection mutagenesistechnology is utilized for breeding a cordyceps militaris mutant strain CGMCC No.14800 for obtaining high-yield cordycepin and fruiting bodies, and the cordyceps militaris mutant strain serves as a fermenting strain for performing liquid fermentation to prepare the cordycepin; the maximum yield of the cordycepin in the obtained fermentation liquid can reach 929.390mu g / mL which is 8.15 times theyield of the cordycepin in the fermentation liquid obtained in the original strain; the strain CGMCC No.14800 is subjected to solid culture, and the maximum yield of the fruiting bodies can reach 22.376g / bottle which is 1.72 times the yield of the fruiting bodies of the original strain; and the maximum yield of the cordycepin in the fruiting bodies can reach 11777.094mu g / g which is 1.75 times theyield of the cordycepin in the fruiting bodies of the original strain. The invention provides a new way for development of cordyceps militaris strains for obtaining high-yield cordycepin.

Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.

Isotopically-enriched graphene and isotope junctions are epitaxially grown on a catalyst substrate using a focused carbon ion beam technique. The focused carbon ion beam is filtered to pass substantially a single ion species including a single desired carbon isotope. The ion beam and filtering together provide a means to selectively isotopically-enrich the epitaxially-grown graphene from given carbon precursor and to selectively deposit graphene enriched with different carbon isotopes in different regions.

The invention relates to a carbon-ion-beam superconductive rotary Gantry. The carbon-ion-beam superconductive rotary Gantry comprises a rotary bracket, a vacuum channel, a combined magnet and scanningmagnets, wherein the vacuum channel is formed in the rotary bracket and is used for providing a vacuum environment for transmission of ion beam currents; the combined magnet is arranged on the periphery of the vacuum channel and is used for carrying out direction guiding and envelope control on carbon ion beams; and the scanning magnets are arranged in front of the last magnet entrance of the combined magnet and are used for regulating positions of ion beam spots in an irradiation field plane at the tail end of the rotary Gantry. Compared with a traditional normal-temperature rotary Gantry, the small-sized and light-weight carbon-ion-beam superconductive rotary Gantry provided by the invention has the advantages that a system adopts currently the most forefront thermo-iron superconductingtechnique in the world, and the volumes and weights of all magnets are substantially reduced except the scanning magnets.

The invention belongs to the technical field of preparation of modified starch, and provides water-resisting starch-based biodegradable plastic master batch and a preparation method thereof. The preparation method of the water-resisting starch-based biodegradable plastic master batch comprises the following steps: after carrying out accelerated focusing on an ion beam generated by an ion source, colliding with starch grains; enabling part of starch molecules to be subjected to chain breakage due to the acidity of particles with positive charges, so as to obtain modified starch; then enabling the modified starch, a cross-linking agent, a starch modifier and an auxiliary agent to commonly react; extruding to obtain the water-resisting starch-based biodegradable plastic master batch. According to the water-resisting starch-based biodegradable plastic master batch and the preparation method provided by the invention, starch molecules are modified by utilizing a carbon ion beam, so that thecrystallization degree of the starch is reduced and the movement of a molecule chain at high temperature is reinforced, and furthermore, the starch has thermal plasticity, high flowability and low viscosity; then the modified starch molecules are subjected to cross-linking modification and extruding processing to prepare the starch-based plastic master batch; the water-resisting starch-based biodegradable plastic master batch has the advantages of simple processing technology, low cost, excellent water resistance and mechanical properties, greenness and environment protection.

The invention comprises a charged particle cancer therapy system used to seal a periphery of a tumor, such as through use of a proton or carbon ion beam searing the outer edges of the tumor, which prevents / hinders nutrient delivery to the tumor resultant in stunted growth of the tumor, halted growth of the tumor, and / or starvation / necrosis of the tumor. Optionally, a tumor sealing layer is formed using multiple passes, of a treatment beam of the charged particle cancer therapy system, across a tumor / healthy tissue boundary layer or voxel.

The invention, which belongs to the field of radiotherapy and radiation detection, discloses a carbon ion range / energy measurement method and device, thereby realizing real-time, in-vivo and non-invasive carbon ion range / energy measurement. With the disclosed method and device, the range uncertainty in the process of carbon ion radiotherapy can be reduced; and the method and device are mainly applied to application occasions needing acquisition of the range / energy of the carbon ion beam in the object. The method comprises: acquiring a prompt gamma energy spectrum generated in the carbon ion treatment process by a measuring device; quantifying a Doppler offset peak position of the characteristic gamma in the energy spectrum; and carrying out calculation based on a numerical algorithm to obtain carbon ion energy and a range. Besides, the device includes a single-slit collimator, a main detector, an active shielding device, a signal amplifying device, a multi-channel data registration andcollecting module, and a computer processing unit. Compared with the traditional method, the carbon ion range / energy measurement method and device have advantages of a non-invasive mode, real-time measurement and detection array avoidance and has the broad application prospects.

The invention discloses a tantalum surface carbonization modification method and a product prepared through the tantalum surface carbonization modification method. The method aims to solve the problems that the melting point of a tantalum material is high, an existing tantalum carbonization surface modification technology is complex in technique, and modified layer structures cannot be controlled easily. According to the method, on the premise that the state of impurities in a vacuum chamber is controlled, methane gas is ionized, a carbon element is introduced to the surface of metal tantalum through bombardment of carbon ion beams, heat generated by bombardment of the ion beams is used for heating so as to help the carbon element diffuse into the metal tantalum, a carbide modified layer is formed on the surface of the metal tantalum, and thus, the melt corrosion resistance of the surface of the metal tantalum is improved. The preparation technique is simple, the production efficiency is high, cost is low, and requirements of industrial large-scale application can be met. Meanwhile, the product prepared through the method has good melt corrosion resistance and is worthy of large-scale application and popularization.

The invention discloses a method for obtaining leymus chinensis mutants by using heavy ion beams to irradiate seed calluses, relates to the technical field of leymus chinensis breeding biology, and solves the three-low problems of low heading rate, low maturing rate and low germination rate of leymus chinensis seeds. After the leymus chinensis callus is subjected to induction culture, selecting faint yellow granular callus obtained by induction culture, and transferring the faint yellow granular callus into a culture dish filled with an induction culture medium for subculture; carrying out irradiation treatment by using a 5Gy carbon ion beam, transferring the callus subjected to irradiation treatment into a sterile culture bottle filled with a differential culture medium, and culturing to obtain adventitious buds; cutting off callus adhered to the base under a sterile condition, and inserting into a rooting culture medium for rooting culture after a rooting point is exposed; and after obvious root systems grow out, carrying out potting culture to obtain the leymus chinensis mutant. According to the invention, new genetic variation can be created, early in-vitro selection is realized, more effective mutants are obtained as new germplasm resources of leymus chinensis, and the breeding process of leymus chinensis is accelerated.

The invention relates to a carbon-based multilayer film which is characterized in that the carbon-based multilayer film comprises a base body, a transition layer and a ta-C layer, wherein the transition layer comprises a metal Ta layer, a metal Ti layer and a TiC layer, and the metal Ta layer, the metal Ti layer, the TiC layer and the ta-C layer are sequentially arranged on the base body in a stacked mode. According to the method, the electric arc is combined with the bias voltage to generate a high-energy carbon ion beam to bombard the metal Ti surface layer, and the TiC layer is formed by implanting the carbon ions into the Ti surface, so that the metal Ti layer and the ta-C layer have very strong interface bonding, the use performance of the film can be remarkably improved, and the service life of the film can be remarkably prolonged.

The invention belongs to the technical field of preparation of modified starch, and provides a water-resistant starch-based biodegradable plastic masterbatch and a preparation method thereof. The invention discloses a method for preparing a water-resistant starch-based biodegradable plastic masterbatch. The ion beam generated by the ion source collides with starch granules after being accelerated and focused, and the positively charged particles break chains of some starch molecules due to their acidity, thus obtaining Modified starch is reacted with cross-linking agent, starch modifier and auxiliary agent to extrude. The present invention uses carbon ion beams to modify starch molecules, reduces the crystallinity of starch, strengthens the movement of its molecular chains at high temperatures, and thus has thermoplasticity, high fluidity and low viscosity, and then cross-links and modifies the modified starch molecules. Starch-based plastic masterbatch can be prepared through chemical and extrusion processing, the processing technology is simple, the cost is low, the water resistance and mechanical properties are excellent, and it is green and environmentally friendly.

The invention discloses a method for screening and cultivating a bolete mutant strain, which belongs to the field of microorganisms, and mainly comprises the following steps: obtaining the bolete mutant strain by using a carbon ion beam irradiation technology, naming the bolete mutant strain as ng2, and preserving the bolete mutant strain with the preservation number of CCTCC (China Center for Type Culture Collection) M 2025077; inoculating the ng2 strain into a hypha rapid germination and propagation solid culture medium PDA or PDA + peptone + beef extract + yeast extract powder, wherein hypha begins to germinate after 4 days; the method comprises the following steps: inoculating a solid strain into a hypha rapid propagation liquid culture medium including cane sugar, corn flour, soybean flour, wheat bran, monopotassium phosphate and yeast extract powder, and generating a large amount of fungus balls within 7 days; inoculating a liquid strain into a fruiting culture raw material self-made fermentation material, corn straw, turfy soil and rice, wherein hyphae overgrow in 30 days; the ng2 strain is high in activity, high in growth speed and suitable for being used as an excellent bolete strain in the Heilongjiang region; the screening and cultivating method of the bolete mutant strain is mainly used for solving the problems that the propagation efficiency of the bolete strain is low, germplasm resources in northern areas such as Heilongjiang are deficient and the like.

The invention relates to a carbon ion source device with a reflector power supply. The carbon ion source device with the reflector power supply comprises an arc chamber, a cover plate, a lamp filament, a cathode, a reflector and a vent hole, the arcing chamber is used as a chamber for generating plasmas by collision of electrons and gas molecules; the cover plate is provided with a leading-out slit used for leading out plasma, and the plasma is led out of the arcing chamber. The filament generates a first group of electrons after being heated, and the first group of electrons are used for heating the cathode; after the cathode is heated, a second group of electrons is generated, and the second group of electrons is used for arcing; the reflecting electrode is arranged on one side, opposite to the cathode, in the arcing chamber and is used for constructing an electric field in the arcing chamber; and the vent hole is formed in the inner wall of the arcing chamber and is used for inputting gas into the arcing chamber. The ion source device provided by the invention can obtain a larger and purer carbon ion beam, the electric field intensity is convenient to adjust, the injection quality is improved, and the product yield is improved.

The invention belongs to the technical field of accelerators, and relates to a multi-layer Faraday cup measurement system and method for carbon ion beam measurement, and the system comprises a housing, a plurality of groups of measurement layers, a slot, and a multipath galvanometer. The measuring layer is arranged in the shell and comprises a metal layer and an insulating layer, the metal layer is arranged on the insulating layer, and the measuring plane of the metal layer is perpendicular to the incident direction of a carbon ion beam; the slot is arranged on the shell, is connected with the metal layer in each group of measuring layers and is used for transmitting a charge signal obtained by the metal layer to the multi-path galvanometer; and the multipath galvanometer is used for analyzing the charge signal obtained by the metal layer to obtain the peak position of the charge quantity curve, and the peak position is the range of the carbon ion beam. The range of the carbon ion beam with the energy of 80-430 MeV can be rapidly obtained, and meanwhile the high range resolution ratio is achieved.

The invention relates to a seedling method for irradiating kiwi fruit seeds through high-energy carbon ion beam, and belongs to the technical field of molecular genetic breeding. The method comprisesthe following steps: firstly, laying the kiwi fruit seeds into a transparent container, and performing high-energy carbon ion beam irradiation on the kiwi fruit seeds, with the irradiation strength being 40 to 100Gy, so as to obtain irradiated kiwi fruit seeds; secondly, sowing the irradiated kiwi fruit seeds into a matrix to culture the kiwi fruit seeds, so as to obtain kiwi fruit seedlings; thirdly, transplanting the kiwi fruit seedlings. Control of the radiation dosage of the high-energy carbon ion beam can achieve the purpose of effective radiation mutation, can further reduce the influence of excessive mutation on the kiwi fruit seeds by the high-energy carbon ion beam. The method can ensure that the germination rate of the kiwi fruit seeds subjected to mutation reaches 26 to 44 percent and the transplanting survival rate is greater than 70 percent, simply and effectively keeps high germination rate and survival rate of the kiwi fruit seeds subjected to mutation, and provides basic conditions for the future research on kiwi fruit materials subjected to high-energy ion mutation and realizing of high-efficiency breeding of kiwi fruit.

The present disclosure provides a method for calculating carbon ion dose distribution in lattice radiotherapy, comprising: obtaining image data of a target, the image data being generated based on a target object according to a target ray; generating a plurality of candidate points according to the image data, the candidate points representing the radiation positions of the carbon ion beams; repeating the following steps until a preset condition is met to obtain the target carbon ion dose distribution: adjusting each candidate point and the corresponding carbon ion beam parameters according to the target parameters and the physical characteristics of the carbon ions; in response to meeting the stop condition, calculating the target carbon ion lattice dose distribution according to the position distribution of each adjusted candidate point and the corresponding carbon ion beam parameters.

The invention discloses a method of manufacturing a ZnO strip optical waveguide by a combination of carbon ion beam irradiation and lithography, which belongs to the technical field of optoelectronicdevice manufacturing. Optical polishing is carried out on the surface and two end surfaces of single crystal ZnO, a strip mask is manufactured on the surface of a sample, carbon ion beam irradiation is then carried out, a photoresist mask is cleaned, and a channel strip optical waveguide is obtained; or, carbon ion beam irradiation is firstly used, the photoresist mask is then made, an Ar ion beamis then used for etching, and a rib optical waveguide is obtained. The formed strip optical waveguide can well keep the optical features of the ZnO crystal and has a hidden application value in aspects of manufacturing of an optical switch and an optical modulator.

The present invention relates to a kind of carbon-based multilayer thin film, it is characterized in that, comprises substrate, transition layer and ta-C layer, and described transition layer comprises metal Ta layer, metal Ti layer and TiC layer, and described metal Ta layer, metal Ti TiC layer, TiC layer and ta-C layer are sequentially stacked on the substrate. The present invention utilizes electric arc combined with bias to generate high-energy carbon ion beams to bombard the metal Ti surface, and forms a TiC layer by implanting carbon ions on the Ti surface, so that the metal Ti layer and the ta-C layer have a strong interfacial bond, which can significantly improve the use of the film. performance and longevity.

The invention discloses a method for reducing the cutting error of a capacitor and battery metal foil cutter. The method comprises the following steps: ultrasonically cleaning the metal foil cutter to remove grease, dehydrating and drying, and putting into a vacuum chamber; starting a cold cathode gas ion source, inputting argon into the cold cathode gas ion source, and performing ion beam polishing treatment on the surface of the metal foil cutter in the vacuum chamber through the led-out argon ions; turning off the cold cathode gas ion source, and turning on the arc ion source, wherein a cathode target and an anode cylinder of the arc ion source are both graphite, arc discharge is generated on the graphite cathode target surface, and then carbon plasma is generated; and leading out carbon ions in carbon plasma through an extraction electrode, enabling the carbon ions to enter a filtering magnetic field, forming pure carbon ion beams through screening of the filtering magnetic field and focusing of a magnetic lens, depositing the pure carbon ion beams on a metal foil cutter through a magnetic scanning deflection field, and forming a uniform amorphous tetrahedral carbon film.

The invention discloses a breeding method for rapidly improving prematurity of corn, and belongs to the technical field of corn breeding. According to the method, the maize inbred line seeds are treated through high-energy carbon ion beam radiation, rapid homozygosis is performed on the screened early-maturing mutants by using a haploid breeding technology, and the improved early-maturing maize DH line can be obtained only through four generations. Compared with a common conventional breeding technology, the method has the advantages that the breeding period is greatly shortened, excellent agronomic characters of original parents are kept while the prematurity is improved, and the purpose of quickly improving the prematurity of the corn is achieved.

The invention discloses a method for improving the surface abrasion performance and prolonging the service life of a nitride coating cutter. The method comprises the following steps that ultrasonically cleaning is carried out on the nitride coating cutter, then dehydrating and drying are carried out, and then the nitride coating cutter is put into a vacuum chamber; a cold cathode penning ion source is utilized, high-energy argon ion beams are adopted for carrying out homogenized ion sputtering treatment on the nitride surface of the nitride coating cutter, then argon ion beam extraction voltage is reduced, ion beam polishing treatment is carried out, and the smoothness of the nitride surface is improved; and arc discharge is utilized, arc discharge is generated on the surface of a cathode graphite target of an arc ion source, carbon plasmas are generated in an anode graphite cylinder of the arc ion source, the carbon plasmas enter a filtering magnetic field to be filtered, then pure carbon ion beams are formed, and the pure carbon ion beams enter a scanning magnetic field after being focused through a magnetic lens field, and uniformly depositing is carried out on the surface of a nitride coating of the polished nitride coating cutter through a magnetic field scanning technology to form an amorphous tetrahedral carbon film.