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Preparation method of polymer microparticles with network structure

A technology of polymer and polymer solution, applied in the high field of network structure, can solve the problems of poor mechanical strength and difficult to achieve mass production process.

Active Publication Date: 2021-01-01
VAIM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned particulate carrier has characteristics such as biodegradability, high porosity, and excellent interconnectivity between pores, but has problems such as poor mechanical strength and difficulty in mass production processes

Method used

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  • Preparation method of polymer microparticles with network structure
  • Preparation method of polymer microparticles with network structure
  • Preparation method of polymer microparticles with network structure

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Experimental program
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Embodiment approach

[0024] The present invention comprises: (1) the polymer solution preparation step, by dissolving the polymer in a mixed solvent comprising ethylene carbonate and dimethyl sulfoxide, to prepare the polymer solution; (2) the solid component preparation step, by increasing the temperature to Liquid hydrocarbons below the freezing point of the mixed solvent are put into the polymer solution obtained in the polymer solution preparation step to prepare a solid component; and (3) a solvent removal step to separate the solid component obtained in the above solid component preparation step solid content, and pour the separated solid content into water to remove the mixed solvent in the solid content.

[0025] Embodiment of the invention

[0026] Hereinafter, the present invention will be described in detail with reference to specific examples.

[0027] The method for preparing polymer fine particles with a network structure of the present invention is characterized in that it includes...

Embodiment 1

[0041] 3.5 g of polylactic acid having a weight average molecular weight of 110,000 was dissolved in 50 ml of ethylene carbonate / dimethylsulfoxide (8:2) mixed solvent to prepare a 7W / V% polymer solution. The above-mentioned polymer solution was sprayed to n-hexane cooled to -15° C. under the conditions that the injection amount of the above-mentioned polymer solution was 5 ml / min and the injection amount of air was 5 l / min. In this case, the sprayed polymer solution is cooled into a spherical shape in low-temperature n-hexane.

[0042] The frozen fine particles thus obtained were poured into cooled (0° C. to 4° C.) distilled water and stirred to remove the mixed solvent, that is, polymer fine particles were obtained by removing ethylene carbonate and dimethyl sulfoxide. After washing with 500 ml of distilled water to remove residual ethylene carbonate and dimethyl sulfoxide, the polymer fine particles of the present invention were obtained by freeze-drying.

Embodiment 2

[0044] Except that ethylene carbonate / dimethyl sulfoxide (8:2) mixed solvent is replaced by ethylene carbonate / dimethyl sulfoxide (7:3) mixed solvent, carry out with the same method as above-mentioned embodiment 1, Thus, polymer fine particles are obtained.

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Abstract

The present invention relates to spraying a polymer solution containing ethylene carbonate by dissolving polyester polymers in a mixed solvent of ethylene carbonate and dimethyl sulfoxide to hydrocarbons at a temperature lower than the freezing point of the mixed solvent to obtain a , dimethyl sulfoxide, and polymer solid components, and then pouring the solid components into water to remove the mixed solvent from the solid components, a method for preparing polymer fine particles with a network structure, the present invention is characterized in that it includes : The polymer solution preparation step is to prepare a polymer solution by dissolving the polymer in a mixed solvent comprising ethylene carbonate and dimethyl sulfoxide; the solid component preparation step is to prepare a polymer solution to a liquid state whose temperature is below the freezing point of the above-mentioned mixed solvent A hydrocarbon is charged into the polymer solution obtained in the polymer solution preparation step to prepare a solid component; and a solvent removal step is to separate the solid component obtained in the above solid component preparation step, and to inject the separated solid into water components to remove mixed solvents in solid components.

Description

technical field [0001] The present invention relates to the preparation method of the macromolecule fine particle that has network structure, relate to in more detail to the hydrocarbon injection that temperature is lower than the freezing point of mixed solvent by making polyester macromolecule dissolve in ethylene carbonate (Ethylenecarbonate, EC ) and dimethyl sulfoxide (Dimethyl sulfoxide, DMSO) in a mixed solvent to obtain a solid component comprising ethylene carbonate, dimethyl sulfoxide, and a polymer, and then drop the solid component into water to obtain the solid component from the above A method for preparing polymer microparticles with a network structure by removing mixed solvents from solid components. Background technique [0002] Porous biodegradable polymer fine particles are widely used as drug delivery system (Drug Delivery System) and tissue regeneration scaffold (Scaffold). Such fine polymer particles need to be porous, and in particular, the strength ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12C08L67/04
CPCC08J3/12C08L67/04
Inventor 金根丰
Owner VAIM