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Cell culture device and cell culture system

A cell culture and cell technology, applied in the direction of tissue cell/virus culture device, measurement device, biochemical cleaning device, etc., can solve the problems of cell development influence, achieve the effect of reducing pollution, relieving stress, and simple device structure

Inactive Publication Date: 2018-08-03
OLYMPUS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in order to check the degree of deterioration of the medium, the operator needs to take out or put the sample into the incubator. At this time, stress such as environmental changes such as temperature and impact during transportation are applied to the cells, which may affect the growth of the cells.

Method used

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  • Cell culture device and cell culture system
  • Cell culture device and cell culture system
  • Cell culture device and cell culture system

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Experimental program
Comparison scheme
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no. 1 Embodiment approach

[0059] The cell culture device 100 according to the first embodiment of the present invention is figure 1 The structure shown in the device. The cell culture device 100 is a device for replacing the medium A in the cell culture container 4 provided in the incubator 5 , and includes an optical data acquisition unit 1 , a medium replacement unit 2 , a control unit 3 , the cell culture container 4 and the incubator 5 .

[0060] Such as Figure 2A As shown, the optical data acquisition unit 1 includes an irradiation optical system 1a for irradiating monochromatic light to the culture medium A in the cell culture container 4, and a measurement unit for measuring the light intensity of the monochromatic light irradiated from the irradiation optical system 1a. Optical system 1b.

[0061] The irradiation optical system 1 a includes a light source 11 for emitting monochromatic light, and the light irradiated from the light source 11 becomes substantially parallel light by a collimat...

no. 2 Embodiment approach

[0078] The cell culture apparatus of the second embodiment of the present invention is equipped with Figure 5A The device of the optical data acquisition unit shown in the first embodiment differs from the first embodiment in that it has a measurement optical system 1c on the optical axis connecting the illumination optical system 1a and the measurement optical system 1b of the cell culture device of the first embodiment. different. Other than that, it is the same as the first embodiment.

[0079] The optical data acquisition unit 1 of this embodiment includes an irradiation optical system 1a for irradiating monochromatic light to the culture medium A in the cell culture container 4, and for measuring A measuring optical system (the first measuring optical system) 1c for measuring the light intensity of a part of the light, and a measuring optical system (the second measuring optical system) for measuring the light intensity of the other part of the monochromatic light irrad...

no. 3 Embodiment approach

[0089] Such as Figure 6A As shown, the cell culture apparatus according to the third embodiment of the present invention is equipped with a drive member 41 for moving the irradiation optical system 1 a and the measurement optical system 1 b of the cell culture apparatus according to the first embodiment relative to each other with respect to the cell culture container 4 This point is different from the first embodiment. Other than that, it is the same as the first embodiment.

[0090] The driving part 41 is controlled by the control unit 15, and can integrate the irradiation optical system 1a (light source 11, collimator lens 12) and the measurement optical system 1b (condensing lens 13, light quantity detector 14) in the horizontal direction (connected to The optical axis of the illuminating optical system 1a and the measuring optical system 1b is moved in a direction perpendicular to the direction).

[0091] The drive member 41 may be provided with, for example, a linear ...

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Abstract

Provided is a cell culture device (100) provided with an incubator (5) capable of maintaining the inside thereof at an environment suitable for cell growth, a cell culture container (4) accommodated inside the incubator (5), an optical data acquiring unit (1) for acquiring optical data of a culture medium in the cell culture container (4), a culture medium exchange unit (2) for exchanging the culture medium in the cell culture container (4), and a control means (3), the cell culture device (100) determining the timing of culture medium exchange on the basis of a temporal change in the opticaldata acquired by the optical data acquiring unit (1).

Description

technical field [0001] The present invention relates to a cell culture device and a cell culture system capable of automatically replacing a medium in a cell culture container. Background technique [0002] In recent years, with the development of stem cell research and regenerative medicine, it is required to modulate a large number of cells. During the culture process, cells absorb oxygen, nutrients and other components needed for development, and emit carbon dioxide and waste. Therefore, since the medium deteriorates when cells are cultured for a long time, it is necessary to periodically replace the medium, and workers must always check the degree of deterioration of the medium. However, in order to check the degree of deterioration of the medium, the operator needs to take out or put the sample into the incubator. At this time, stress such as environmental changes such as temperature and impact during transportation are applied to the cells, which may affect the growth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00C12M3/00
CPCC12M41/00C12M31/00C12M31/08C12M31/10C12M41/06G01N21/0303G01N21/0332C12M41/30G01N21/17C12M25/10C12M29/00C12M31/04
Inventor 佐佐木浩南达哉真柄泰典
Owner OLYMPUS CORP
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