Anti-thrombotic bone cement

Abstract

The invention discloses anti-thrombotic bone cement. The bone cement is PMMA bone cement with a two-ingredient system, the two-ingredient system is prepared from a powder ingredient and a liquid ingredient, and in the powder ingredient, each 40g powder contains 4000 to 24000 AxaU of enoxaparin sodium. The bone cement disclosed by the invention can ensure that thrombus cannot be formed in a part towhich the bone cement is applied and reduce the risk of bone cement pulmonary embolism under the situation that subcutaneous injection of low-molecular-weight heparin sodium is paused before operation; not only is hypocoagulability caused by subcutaneous injection heparin anticoagulation of a whole-body coagulation system avoided, but also thrombus is effectively prevented from being formed at anoperation part and a part at the bone cement embedding periphery; furthermore, the situation that a patient generally uses anticoagulant drugs 12 hours after operation is not affected, and very highclinical application value is achieved. In addition, the bone cement disclosed by the invention ensures that the enoxaparin sodium can be slowly released under the premise that biological mechanical property is not changed relative to that of existing bone cement; thus, an effect on the whole-body coagulation system of the paint is small, and safety is higher.

Description

technical field [0001] The invention relates to a medical bone cement composite material, in particular to an antithrombotic bone cement. Background technique [0002] Bone cement is a commonly used material for joint prosthesis fixation in orthopedic surgery. After a short period of rehabilitation after surgery, the replaced joint can function. Moreover, this kind of fixation is quite reliable and can last for more than ten years, or even more than twenty years. Bone cement has formed two major systems during the development process, one is calcium phosphate bone cement, and the other is polymethyl methacrylate bone cement. Polymethyl methacrylate (PMMA) bone cement is generally a two-component system (liquid component and powder component). When used, as long as it is mixed in a certain proportion, it can undergo polymerization reaction at room temperature and gradually solidify. The process only takes ten minutes. [0003] The liquid components of PMMA bone cement mainl...

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide an antithrombotic bone cement to solve the problems of a series of complications such as blood pressure drop, dyspnea, deep vein thrombosis, and pulmonary embolism after implantation that exist in the application of existing PMMA bone cement.

Images