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A fluorescent-magnetic dual-functional microsphere and its preparation method

A dual-function, magnetic technology, applied in the direction of inorganic material magnetism, instruments, measuring devices, etc., to achieve the effect of remarkable fluorescence characteristics and magnetic resonance characteristics, easy availability of raw materials and good effects

Active Publication Date: 2021-03-05
湖北新纵科病毒疾病工程技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Magnetic silica microspheres as a new type of magnetic material and phycoerythrin as an excellent fluorescent material are excellent choices for preparing fluorescent-magnetic dual-functional materials, but no in-depth reports on this aspect have been seen in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A kind of fluorescence-magnetic bifunctional microsphere, its preparation method comprises the steps:

[0024] S1. Weigh 1g of magnetic iron ferric oxide nanoparticles, add 10mL of 0.01M hydrochloric acid solution, ultrasonically treat for 20min (20-40kHz, 100-500W), separate with a magnet and wash with ultrapure water until neutral, then add 80mL of absolute ethanol in turn , 20mL ultrapure water, 0.4mL ammonia water and 0.5mL tetraethyl orthosilicate, ultrasonically reacted for 2h (20-40min, 100-500W), washed with ultrapure water until neutral to obtain magnetic silica microspheres.

[0025] S2. Weigh 1g of magnetic silica microspheres, add 80mL of absolute ethanol, 20mL of ultrapure water, 0.4mL of ammonia water and 0.5mL of KH-560 for ultrasonic reaction for 2h (20~40kHz, 100~500W), and then separate the solid and liquid. Wash with ultrapure water until neutral to obtain epoxidized magnetic silica microspheres.

[0026] S3. Take 2g of iminodiacetic acid and dissolv...

Embodiment 2

[0029] A kind of fluorescence-magnetic bifunctional microsphere, its preparation method comprises the steps:

[0030] S1. Weigh 1g of magnetic iron ferric oxide nanoparticles, add 40mL of 0.05M hydrochloric acid solution, ultrasonically treat for 30min (20-40kHz, 100-500W), separate with a magnet and wash with ultrapure water until neutral, then add 110mL of absolute ethanol in turn , 50mL ultrapure water, 1.2mL ammonia water and 3mL tetraethyl orthosilicate, ultrasonically reacted for 4h (20-40kHz, 100-500W), washed with ultrapure water until neutral to obtain magnetic silica microspheres.

[0031] S2. Weigh 1g of magnetic silica microspheres, add 120mL absolute ethanol, 50mL ultrapure water, 1.1mL ammonia water and 2mL KH-560 ultrasonic reaction for 3h (20~40kHz, 100~500W), and separate the solid and liquid with Wash with ultrapure water until neutral to obtain epoxidized magnetic silica microspheres.

[0032] S3. Weigh 2-4g of iminodiacetic acid and dissolve it in 25mL of ...

Embodiment 3

[0035] A kind of fluorescence-magnetic bifunctional microsphere, its preparation method comprises the steps:

[0036] S1. Weigh 1g of magnetic iron ferric oxide nanoparticles, add 40mL of 0.1M hydrochloric acid solution, ultrasonically treat for 40min (20-40kHz, 100-500W), separate with a magnet and wash with ultrapure water until neutral, then add 160mL of absolute ethanol in turn , 80mL ultrapure water, 1.6mL ammonia water and 4mL tetraethyl orthosilicate, ultrasonically reacted for 5h (20-40kHz, 100-500W), washed with ultrapure water until neutral to obtain magnetic silica microspheres.

[0037]S2. Weigh 1g of magnetic silica microspheres, add 160mL absolute ethanol, 20-80mL ultra-pure water, 1.6mL ammonia water and 4mL KH-560 ultrasonic reaction for 5h (20-40kHz, 100-500W), and separate the solid and liquid , washed with ultrapure water until neutral to obtain epoxidized magnetic silica microspheres.

[0038] S3. Take 4g of iminodiacetic acid and dissolve it in 30mL of 1....

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PUM

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Abstract

The present invention relates to a fluorescent-magnetic bifunctional microsphere and a preparation method thereof. The method comprises the following steps: S1. Preparation of magnetic silica microspheres; S2. Conducting magnetic silica microspheres through KH-560 and related solvents Epoxidation to obtain epoxidized magnetic silica microspheres; S3. Carboxylation of epoxidized magnetic silica microspheres to obtain carboxylated magnetic silica microspheres; S4. The compound of phycoerythrin and carboxylated magnetic silica microspheres is obtained. The beneficial effects are: for the first time, using magnetic silica microspheres as the magnetic material and phycoerythrin as the fluorescent material, a fluorescent-magnetic dual-functional microsphere was successfully compounded, with remarkable fluorescence and magnetic response characteristics; first passed KH-560 The silica microspheres are epoxidized, and then the epoxidized silica microspheres are carboxylated, the carboxylation effect is better, and the ability of coupling and binding to phycoerythrin is also significantly enhanced.

Description

technical field [0001] The invention belongs to the field of functional materials, in particular to a fluorescent-magnetic double-functional microsphere and a preparation method thereof. Background technique [0002] Magnetic materials in the prior art are roughly divided into four categories: metals, metal ions, iron oxides, and metal ferrites. Magnetic mesoporous silica new nanocomposite material is a new type of magnetic material, its structure can be adjusted in micropore, mesopore and macroscopic, so that it can be used in targeted drug, biological enrichment and separation, magnetic hyperthermia, Immobilized enzymes, macromolecular catalysis, adsorption separation and other fields have great application prospects and have attracted the attention of many scientific researchers. The new nanocomposite material not only has the characteristics of unique magnetic response function, low toxicity and easy surface functionalization, but also has the following excellent proper...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/533G01N33/543H01F1/01
CPCG01N33/533G01N33/54326H01F1/01
Inventor 王华林张涛张科登
Owner 湖北新纵科病毒疾病工程技术有限公司