Unlock instant, AI-driven research and patent intelligence for your innovation.

Method of filling a container with a foaming composition

A composition and container technology, applied in the field of preparation of compositions containing gaseous microbubbles, capable of solving problems such as continuation and inability to reach headspace gas

Active Publication Date: 2021-08-10
GE HEALTHCARE AS
View PDF15 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the applicant faced the problem that when filling the container with the contrast medium, foam and large air-containing balloons are occasionally produced, possibly due to the Venturi effect, and such large air bubbles The headspace gas continues to exist during the delivery of the headspace gas into the vessel
As a result, the desired amount of headspace gas cannot always be achieved in said headspace

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: comparative example -- exhaust air after utilization, Optison TM Filling into containers using a Groninger filling machine for filling with Optison TM vials are aseptically dispensed, stoppered, capped and crimped.

[0037] The Optison solution was pumped from the bulk container by means of a peristaltic pump and dispensed into 500 3 mL vials. The pump speed was set at 140 rpm and the pump acceleration was 100%. Thereafter, the vial was deaerated by flowing perfluoropropane gas (OFP) at a flow rate of 300 cc / min in and down the tube. Afterwards, the Groninger filler stoppers, caps and crimps the caps.

[0038] In the course of testing a production batch of perfluoropropane headspace, 90 samples were tested and 3 of them did not meet the headspace standard of at least 60% headspace. For 3 non-conforming samples, carry to the end of the run. In order to verify the test results, repeat and additional experimental tests were performed. These tests includ...

Embodiment 2

[0040] Example 2: Optison TM Filling into containers using a Groninger filling machine for filling with Optison TM vials are aseptically dispensed, stoppered, capped and crimped.

[0041] Referring to Example 1, investigations have shown that perfluoropropane headspace content is not optimized using post-fill purge. However, it was determined that pre-fill perfluoropropane purge of empty vials prior to filling at a purge rate of 500 cc / min significantly improved perfluoropropane headspace content.

[0042] At a flow rate of 500 cc / min, 500 3 mL vials were pre-vented by flowing perfluoropropane gas into and surrounding the empty vials. The Optison solution is then pumped from the bulk container by means of a peristaltic pump and dispensed into vials. The pump speed was set at 100 rpm and the pump acceleration was 50%. Afterwards, the Groninger filler stoppers, caps and crimps the caps.

[0043] During the described procedure, 90 vials out of 500 were withdrawn for headspac...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a process for the preparation of compositions comprising gaseous microbubbles. More particularly, the invention relates to methods of filling such compositions into containers. The prepared composition is preferably an ultrasound contrast agent composition which can be provided in a container, wherein the headspace of the container contains the same gas as the gas in the microbubbles.

Description

[0001] This application is a divisional application of an invention application with a filing date of April 26, 2013, a Chinese national application number of 201380022644.4, and an invention title of "Method for Filling a Foaming Composition into a Container". technical field [0002] The present invention relates to a method of preparing a composition comprising gaseous microbubbles. More particularly, the present invention relates to methods of filling said compositions into containers. The prepared composition is preferably an ultrasound contrast agent composition provideable in a container, wherein the headspace of the container contains the same gas as the microbubbles, and wherein the gas is different from air. Background technique [0003] It is well known that ultrasound imaging comprises a valuable diagnostic tool, for example for the study of the vascular system, especially for cardiography, and for the study of tissue microvasculature. A variety of ultrasound co...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B65B31/00B67C3/10B01D19/02C09K23/30
CPCB65B31/00B65B3/003B01D19/02A61J1/00A61K49/223B65B31/04B65B31/042B65B7/28
Inventor S.克瓦勒C.P.通塞思O.J.托克鲁德
Owner GE HEALTHCARE AS