Cinnamyl amino acid compound and application thereof

A technology of cinnamoyl amino acids and compounds, applied in the field of cinnamoyl amino acid compounds, can solve problems such as difficult to pass through the blood-brain barrier, concentration maintenance time period, and limited clinical application, and achieve clear pharmacological effects, small toxic and side effects, and inhibition of iNOS Effect
CN108484431AInactive Publication Date: 2018-09-04CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2018-09-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a cinnamyl amino acid compound and application thereof, relates to the fields of medicinal chemistry and pharmacotherapeutics and in particular relates to a cinnamyl amino acidcompound with inducible nitric oxide synthase (iNOS) inhibitory activity or pharmaceutically acceptable salts or esters thereof, pharmaceutical compositions containing the compounds and medical application thereof, particularly application in prevention and treatment of neuronal cell damage related neurodegenerative diseases comprising ischemic cerebral apoplexy, Parkinson's disease and other aspects.
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Description

technical field

[0001] The present invention relates to a cinnamoyl amino acid compound, in particular to a cinnamoyl amino acid compound having inducible nitric oxide synthase (iNOS) inhibitory activity, and its use in the treatment and prevention of ischemic stroke and Parkinson's disease The application in the medicine of the present invention belongs to the technical field of pharmacy. Background technique

[0002] Acute ischemic stroke is characterized by high incidence, high disability and high mortality. Epidemiological survey results show that the onset of this type of disease is gradually becoming younger, which has attracted extensive attention. Inflammation plays an important role in the pathological process of ischemia-induced brain injury. One of the important signs of inflammatory response after cerebral ischemia is the activation of glial cells. Glial cells are the most numerous type of immune cells in the central nervous system. They can not only provide nu...

Claims

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