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A composition and liver injury technology, applied in the field of medicine, to achieve the effect of improving pathological changes and reducing the level of TNF-α
Inactive Publication Date: 2018-09-07
石鹏飞
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At present, there is still no effective treatment for liver injury. Therefore, there is an urgent need in this field to develop new drugs with good curative effect for alleviating or treating symptoms of liver injury and reducing mortality.
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experiment example 1
[0020] The characterization of experimental example 1 medicine of the present invention
[0021]
[0022] 1 H NMR (400MHz, DMSOd 6 ):δ8.80(s,1H),8.03(d,1H),7.37(s,1H),7.33(d,1H),4.48(dd,1H),4.35-4.22(m,2H),3.72( t,2H),3.31-3.38(m,1H),3.33(s,3H),3.24-3.16(m,1H),1.62(td,1H),0.88(d,3H),0.71(d,3H) .
[0023] MS measured value (ESI + )[(M+H) + ]:376.
experiment example 2
[0024] Experimental example 2 The therapeutic effect of the medicine of the present invention on liver injury
[0025] Animal grouping and dosing
[0026] 60 mice were randomly divided into 6 groups, respectively normal group, model group, positive control group, low, medium and high dose groups of the drug of the present invention, with 10 mice in each group. References (Xiao Xiaohua, Xu Liying, Zhou Yanyan, et al. Study on the hepatoprotective effect of geniposide and crocin I on liver injury in mice induced by ANIT[J]. Shi Zhen Guo Yi Guo Yao, 2014, 25(7): 1600-1601 .) Modeling, continuous administration for 7 days, normal group and model group were administered with normal saline every day, and the positive control group was given bifendate 10mg·kg every day -1 , the low, middle and high dose groups of the medicine of the present invention are given 5, 10, 20 mg·kg respectively every day -1 Drugs in Example 1. 1 hour after administration on the fifth day, igα-naphthyl i...
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Abstract
The present invention relates to a liver injury treating pharmaceutical composition, which comprises a compound represented by the following formula and used as an effective pharmaceutical component,and a pharmaceutically acceptable auxiliary additive, wherein the formula is defined in the specification, and R1 is independently selected from H or alkyl. According to the present invention, by inhibiting the lipid peroxidation reaction and scavenging the free radicals, the liver injury treating pharmaceutical composition can produce the anti-liver-injury effect, reduce the TNF-alpha level in serum, and significantly improve the pathological change of liver tissue.
Description
technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating liver damage. Background technique [0002] The liver is the largest organ in the body and has extremely important functions such as digestion and metabolism, detoxification, and reuse of metabolites. The loss of liver cell metabolic function and damage to the structural integrity of cytoplasmic junction caused by various injury factors will cause the loss of liver functions such as choleretic, blood coagulation, and synthesis, and produce a series of clinical symptoms. At present, there is still no effective treatment for liver injury. Therefore, there is an urgent need in this field to develop new drugs with good curative effect for alleviating or treating symptoms of liver injury and reducing mortality. Contents of the invention [0003] The object of the present invention is to provide a pharmaceutical composition for...
Claims
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Application Information
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