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Application of traditional Chinese medicine composition in preparation of medicine for treating oral ulcer

A technology for oral ulcers and compositions, which is applied to the application field of traditional Chinese medicine compositions in the preparation of drugs for treating oral ulcers, can solve the problems of oral mucosal exfoliation, uncertain curative effect, single action target, etc., and achieves reduction of TNF-α level, The effect of reducing the area of ​​oral ulcers and improving immune function

Pending Publication Date: 2021-09-17
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The drugs for the above treatments are mainly western medicines, mostly hormones, anesthesia, immunomodulators, and vitamins. These drugs have uncertain curative effects, many side effects, etc., and are prone to drug resistance, with high recurrence rates and adverse reactions. In severe cases, it can cause flora imbalance, oral mucosal peeling and superimposition, and the target is single. Long-term use will affect the health of patients

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicine for treating oral ulcer
  • Application of traditional Chinese medicine composition in preparation of medicine for treating oral ulcer
  • Application of traditional Chinese medicine composition in preparation of medicine for treating oral ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Experimental Study of Shenqi Jiangtang Granules on Oral Ulcers in Rats

[0021] Oral ulcer models were made with acetic acid, and Shenqi Jiangtang granules were given to oral ulcer model rats a certain number of times a day to observe whether Shenqi Jiangtang granules could reduce ulcers.

[0022] 1 Experimental animals, drugs

[0023] Animals: 60 SPF rats, half male and half female, body weight 180-220 g, provided by Lunan Pharmaceutical Group Co., Ltd., license: SYXK (Lu) 20180008.

[0024] Shenqi Jiangtang Granules (Z10950075, produced by Lunan Houpu Pharmaceutical Co., Ltd.); Guilin Watermelon Cream (Z45021599, produced by Guilin Sanjin Pharmaceutical Co., Ltd.). Other reagents or materials can be obtained through commercial channels unless otherwise specified.

[0025] 2 test method

[0026] 2.1 Model establishment: Except for the blank group, the above rats were anesthetized with 10% chloral hydrate at a dose of 0.35ml / 100g. After anesthesia, 20% acet...

experiment example 2

[0042] Experimental Example 2 Experimental Study of Shenqi Jiangtang Granules on Oral Ulcers in Rats

[0043] Rats were modeled by immunological methods. After the model was successfully established, rats in the oral ulcer model group were given a certain dose of Shenqi Jiangtang Granules every day, and the CD of T cell subsets in rat serum was determined. 4 + 、CD 8 + Content and CD 4 + / CD 8 + value.

[0044] 1 Experimental materials

[0045] Experimental animals SPF grade rats were provided by Lunan Pharmaceutical Group Co., Ltd., a total of 70, half male and half male, weighing 180-220g. Shenqi Jiangtang Granules (Z10950075, produced by Lunan Houpu Pharmaceutical Co., Ltd.); Vitamin B12 (produced by China Resources Zizhu Pharmaceutical). Complete Freund's adjuvant was purchased from Sigma, CD 3 + 、CD 4 + 、CD 8 + Immunohistochemical kits were purchased from Boster; other reagents or materials can be obtained through commercial channels unless otherwise specifi...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses application of a traditional Chinese medicine composition in preparation of a medicine for treating oral ulcer. The traditional Chinese medicine composition comprises 11 medicinal materials such as ginseng stem and leaf total saponins, astragalus membranaceus, rehmannia, Chinese yam, radices trichosanthis, raspberry, radix ophiopogonis, schisandra chinensis, fructus lycii, rhizoma alismatis and poria cocos. The traditional Chinese medicine composition disclosed by the invention can be used for remarkably reducing an area of oral ulcer and effectively reducing a level of TNF-alpha in oral ulcer tissues of rats. For recurrent oral ulcer caused by decline of immune functions of rats, after the composition is adopted for intervention, CD3 + cell level in serum of the rats is increased, and meanwhile, a ratio of CD4 + / CD8 + is up-regulated, indicating that the composition can improve immune functions of rats, effectively treat oral ulcer caused by abnormal immune function, and enrich selectivity of clinical medication.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of a traditional Chinese medicine composition in the preparation of medicines for treating oral ulcers. Background technique [0002] Oral ulcer (oral ulcer, OU) is a common oral disease that often recurs, and the prevalence rate in the population is very high, which can be as high as more than 20%. Folks generally call it "oral burning" or "oral sores". It is a localized ulcer injury of the oral mucosa characterized by periodic and repeated attacks, which can heal itself and can occur in any part of the oral mucosa. It is more common in the mucous membranes of the lips, cheeks, soft palate, or gums of the oral cavity, where single or multiple round or oval ulcers of various sizes occur, the surface is covered with gray or yellow pseudomembrane, the center is depressed, the boundary is clear, and the surrounding mucosa is red Sli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P1/02
CPCA61K36/258A61K36/79A61K36/57A61K36/481A61K36/8945A61K36/804A61K36/73A61K36/8968A61K36/076A61K36/428A61K36/884A61K36/815A61P1/02A61K2300/00
Inventor 李蔚群沈素芹
Owner LUNAN PHARMA GROUP CORPORATION
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