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Method for generating micro-droplets by controlling flow focusing type microfluidic chip through vibration pipeline

A microfluidic chip, a technology for controlling flow, which can be used in measuring tubes/pipettes, chemical instruments and methods, and containers for laboratory use. Process instability and other problems, to achieve the effect of consistent particle size, improved stability, and improved production efficiency

Inactive Publication Date: 2018-09-07
CHINA JILIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a new method for the existing flow-focused microfluidic chip to generate micro-droplets, which are difficult to control the size of micro-droplets, experimental repeatability, and unstable generation process. Controlling the generation of microdroplets in a flow-focused microfluidic chip

Method used

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  • Method for generating micro-droplets by controlling flow focusing type microfluidic chip through vibration pipeline
  • Method for generating micro-droplets by controlling flow focusing type microfluidic chip through vibration pipeline

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Embodiment Construction

[0015] Such as figure 2 As shown, taking the process of generating micro-droplets in the flow-focused microfluidic chip as an example, the specific embodiment of the present invention is to push the micro-sampler 8 through the syringe pump 9 to make the fluid enter The dispersed phase pipeline 6 passes through the mechanical vibrator 7 to make the fluid flow into the flow-focused microfluidic chip 13 . The syringe pump 10 pushes the micro-sampler 11 to make the fluid enter the continuous phase pipeline 12 and flow into the flow-focused microfluidic chip 13 . Two immiscible fluids meet in a narrow channel and touch each other, breaking apart to form droplets. Due to the fluid flow, the micro-droplets enter the collection bottle 4 through the outlet pipeline 5, and this process continuously generates micro-droplets. When the mechanical vibrator 7 is activated, the size of the micro-droplets can be precisely controlled by changing the amplitude and frequency of the mechanical ...

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Abstract

The invention discloses a method for generating micro-droplets by controlling a flow focusing type microfluidic chip through a vibration pipeline. According to the method disclosed by the invention, in a system for generating the micro-droplets through the flow focusing type microfluidic chip, mechanical vibration with controllable amplitude and frequency is applied to a dispersion-phase fluid pipeline of the outer part of the chip through a mechanical vibrator, and the generation of the micro-droplets in the flow focusing type microfluidic chip is controlled. According to the method disclosedby the invention, the amplitude and frequency of the mechanical vibrator of the outer part are controlled to realize the aims of generating the micro-droplets with different sizes, controlling the generation frequency of the droplets and also improving the generation frequency of the micro-droplets.

Description

technical field [0001] The invention belongs to the field of fluid machinery, and relates to a method for controlling a flow-focused microfluidic chip to generate microdroplets by a vibrating pipeline. Background technique [0002] In recent years, micro-droplet technology has received widespread attention due to its important influence in the field of scientific research and special applications in the field of engineering. Researchers have proposed many methods to form approximately monodisperse micro-droplets, such as dripping faucets, nozzle release, microfluidic technology and so on. Among these technologies, droplet microfluidics is the most common method, which can be used in food delivery, drug delivery, chemical reaction, health monitoring and some other bioanalysis fields. In general, there are three typical geometries that can be used to generate microdroplets: T-shaped pipes, flow-focusing pipes, and coaxial flow pipes. Among them, the flow-focusing pipeline ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00B01L3/00B01L3/02
Inventor 包福兵林晓会凃程旭尹招琴高晓燕张凯孔明
Owner CHINA JILIANG UNIV
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