A method for detecting illegal drugs by using internally modified molecular tubes as chemical sensors
A technology of chemical sensors and molecular tubes, applied in the field of drug detection, can solve problems such as time-consuming, labor-intensive, costly, and high
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Embodiment 1
[0039] At 25 °C, 100 μL of the inner modified molecular tube shown in formula I (5 × 10 -6 The aqueous solution of M) was added to the 96-well plate, and then 50 μL of synephrine solutions of different concentrations prepared with simulated urine were added successively. Detected with a fluorescence reader, the detection conditions were excitation wavelength 350 nm, emission wavelength 403 nm, repeated 12 times. The result is as follows figure 1 shown.
[0040] from figure 1 It can be seen that the detection limit of synephrine for the inner modified molecular tube shown in formula I is 1.4 μg / mL, and the linear range is 0-50 μM.
Embodiment 2
[0042] At 25 °C, 100 μL of the inner modified molecular tube shown in formula I (5 × 10 -6 The aqueous solution of M) was added to the 96-well plate, and then 50 μL of procaine hydrochloride solutions of different concentrations prepared with simulated urine were added successively. The concentrations of ephedrine in each sample were 0, 15, 20, 25, 30, 40, 50 and 80 μM, detected with a fluorescence reader, the detection conditions were excitation wavelength 350 nm, emission wavelength 403 nm, repeated 12 times. The result is as follows figure 2 shown.
[0043] from figure 2 It can be seen that the detection limit of procaine hydrochloride by the inner modified molecular tube shown in formula I is 0.7 μg / mL, and the linear range is 0-30 μM.
Embodiment 3
[0045] At 25°C, 100 μL of the inner modified molecular tube (5×10 -6 The aqueous solution of M) was added to the 96-well plate, and then 50 μL of procaine hydrochloride solutions of different concentrations prepared with simulated urine were added successively. The concentrations of ephedrine in each sample were 0, 15, 20, 25, 30, 40, 50 and 80 μM, detected with a fluorescence reader, the detection conditions were excitation wavelength 350 nm, emission wavelength 403 nm, repeated 12 times. The result is as follows image 3 shown.
[0046] from image 3 It can be seen that the detection limit of procaine hydrochloride by the inner modified molecular tube shown in formula II is 3.1 μg / mL, and the linear range is 0-80 μM.
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