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Veterinary procaine penicillin-dihydrostreptomycin sulfate suspension injection and preparation method thereof

A technology of dihydrostreptomycin sulfate and procaine penicillin, which is applied to medical preparations containing active ingredients, liquid delivery, and pharmaceutical formulations, can solve the problems of technical disclosure of the combination of two drugs, and achieve Effects of improving convenience, expanding antibacterial spectrum, and facilitating clinical use

Inactive Publication Date: 2013-09-18
CHONGQING FANGTONG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, there is no disclosure of the technology of compounding the two drugs

Method used

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  • Veterinary procaine penicillin-dihydrostreptomycin sulfate suspension injection and preparation method thereof
  • Veterinary procaine penicillin-dihydrostreptomycin sulfate suspension injection and preparation method thereof
  • Veterinary procaine penicillin-dihydrostreptomycin sulfate suspension injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Procaine penicillin 5g, dihydrostreptomycin sulfate 5g, appropriate amount of citrate buffer, sodium methylparaben 0.02g, polyvinylpyrrolidone 0.5g, sodium carboxymethylcellulose 0.2g, Promethacin hydrochloride Caine 0.5g, sodium dithionite 0.02g, and water for injection were added to 100ml.

[0028] Preparation method: Take 50ml of water for injection, add suspending agent, soak for 8 hours, add polyvinylpyrrolidone to disperse evenly, add procaine penicillin, stir and mix evenly, add preservative dissolved in 20ml of water for injection, procaine hydrochloride Because of sodium dithionite, add buffer solution, adjust the pH value to about 7.0, constant volume, under the set pressure of the equipment 25Mpa, pass through the homogenizer twice, mix evenly, and pack it. The pressure and pH value are only the setting indexes of the operation, and the requirements are not strict, and fluctuations within the scope defined by the present invention are all allowed.

Embodiment 2

[0030] Procaine penicillin 10g, dihydrostreptomycin sulfate 10g, appropriate amount of acetate buffer, methylparaben 0.5g, polyvinylpyrrolidone 2.5g, carboxymethylcellulose sodium 0.3g, procaine hydrochloride 1.0g, 0.3g of sodium dithionite, and water for injection to 100ml.

[0031] The preparation method is the same as in Example 1.

Embodiment 3

[0033] Procaine penicillin 20g, dihydrostreptomycin sulfate 20g, appropriate amount of phosphate buffer, propylparaben 1.05g, polyvinylpyrrolidone 10g, carboxymethylcellulose 0.4g, procaine hydrochloride 1.5g, Sodium dithionite 0.35g, add water for injection to 100ml.

[0034] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a veterinary drug and particularly relates to a veterinary procaine penicillin-dihydrostreptomycin sulfate suspension injection and a preparation method thereof. The injection comprises 5%-30% (w / v) of procaine penicillin, 5%-30% (w / v) of dihydrostreptomycin sulfate, a proper dosage of buffer solution, 0.02%-0.2% (w / v) of a preservative, 0.5%-15% (w / v) of a dispersing agent, 0.2%-20% (w / v) of a suspending agent, 0.5%-2% (w / v) of a stabilizer and local analgesic and 0.02%-0.5% (w / v) of an antioxidant, wherein the dispersion medium is injection water. According to the invention, the procaine penicillin and the dihydrostreptomycin sulfate are creatively formed to a compound preparation, which not only improves the application convenience of the two drugs, but also expands the antibacterial spectrum of the drugs to greatly facilitate the clinical use of veterinaries, and meanwhile, specific ingredients are selected and utilized to solve the problem of preparing the suspension injection with water as medium.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to a procaine penicillin-dihydrostreptomycin sulfate suspension injection and a preparation method thereof. Background technique [0002] Procaine penicillin is a β-lactam antibiotic commonly used in veterinary clinics. Due to its inherent characteristics, its aqueous solution is easily hydrolyzed and ineffective. Therefore, procaine penicillin powder injection and procaine penicillin suspension injection prepared with oil as the dispersion medium are traditionally used. [0003] Dihydrostreptomycin sulfate is obtained by reducing the aldehyde group of streptomycin in streptomycin to a primary alcohol group. Although it has been listed as an obsolete species in medical clinics, it still has a certain market in veterinary clinics. , especially in the United States, Europe, Southeast Asia and other countries. In clinical application, the commonly used dosage form is powder injection. [0004] I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K9/10A61P31/04A61K31/43
Inventor 唐建华龚聪宋小红
Owner CHONGQING FANGTONG ANIMAL PHARMA
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