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Coupling model control method for particle movement in terminally closed microchannels

A control method and coupled model technology, applied in the field of microfluidics, can solve the problems of applying electric field and force incompetence, and achieve the effect of rapid parameter identification

Active Publication Date: 2021-02-26
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As one of the main research hotspots in microfluidics in the past ten years, electrodynamic drive has relatively mature research on particle movement, but it seems powerless to apply an electric field in these relatively biased "branch" structures with terminal closures.
However, through chemical methods, designing the chemical conditions for particle movement poses a great challenge to existing technologies.

Method used

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  • Coupling model control method for particle movement in terminally closed microchannels
  • Coupling model control method for particle movement in terminally closed microchannels
  • Coupling model control method for particle movement in terminally closed microchannels

Examples

Experimental program
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Effect test

Embodiment 1

[0062] like Figure 1 to Figure 8 As shown, the particle movement coupling model control method in the terminal closed microchannel includes a model channel and a control device; the model channel includes a main microchannel and a branch channel, and one end of the main microchannel and the branch channel is connected and fixed, and the branch channel The other end of the road channel is closed, and the inlet of the main micro channel is provided with a micropump to control the solution entering, and the branch channel is in a vacuum state; the solution includes NaCl solution with fluorescent particles, NaCl solution and oil droplets; wherein the injection of oil droplets is In order to prevent the NaCl solution with fluorescent particles from mixing with the NaCl solution; the control device includes a micropump, a mobile control chip and a high-speed camera, and the micropump and the high-speed camera are connected to the mobile control chip. The specific mobile chip process...

Embodiment 2

[0091] like Figure 1 to Figure 8As shown, the fluorescent particle movement coupling model control method in the branch channel includes a model channel, a control device and an observation device; the model channel includes a main microchannel, a branch channel and a solution entry channel, and the control device includes a micropump, A mobile control chip, the observation device includes a microscope objective lens, a color filter, a high-speed camera, and a laser. The mobile control chip is set on the branch channel, and the position where the laser is set passes through the excited light source, and the generated optical path passes through the microscope objective lens to reach the mobile control chip, and the high-speed camera monitors the concentration information of the two-dimensional fluorescent particles in the branch channel, thereby establishing a micro control model.

[0092] Specifically include the following steps:

[0093] 101) Model building step: the main...

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Abstract

The invention discloses a control method for a migration coupling model of fluorescent particles in a terminal closed micro-channel, and the method employs a model channel and a control device. The model channel includes a main micro-channel and a branch channel, wherein the main micro-channel is fixedly connected with one end of the branch channel, and the other end of the branch channel is closed. The inlet of the main micro-channel is provided with a micro-pump for controlling the entry of solution, and the branch channel is in a vacuum state. The solution contains NaCl solution with fluorescent particles, NaCl solution and oil drops. The control device comprises a micro-pump, a mobile control chip and a high speed camera, wherein the micro-pump and the high speed camera are connected with the mobile control chip. The method provided by the invention achieves the fast parameter identification and optimal and precise control of the mobile diffusion of boundary solution.

Description

technical field [0001] The invention relates to the field of microfluidics, more specifically, it relates to a particle movement coupling model control method in a terminal closed microchannel. Background technique [0002] In the 20th century, people achieved strategic information science and technology with the help of "information" obtained by the flow of electrons in semiconductors or metals; in the 21st century, mobile control chips are controlled by aqueous solutions with soluble biomolecules or suspended cells. Flowing on channels or planes to study life, understand life, and even partially transform life, it will also be possible to achieve a new strategic science and technology: microfluidics. Particle movement in microchannels is one of the hotspots in microfluidics research. However, in a terminally closed microchannel, since its one-end closed geometry does not allow a net fluid flow, how to effectively transport particles into the terminally closed geometry is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G05B13/04
CPCG05B13/042
Inventor 陈特欢蔡振宇
Owner NINGBO UNIV