Citicoline injection pharmaceutical composition, as well as preparation method and application thereof

Abstract

The invention concretely relates to a citicoline injection, as well as a preparation method and application thereof. The citicoline injection provided by the invention is prepared from the following raw materials: citicoline, activated carbon, traditional Chinese medicine extracts and water for injection. The preparation method of the citicoline injection comprises the following steps of (1) preparing and weighing various raw materials according to a prescription; (2) adding an appropriate amount of water for injection into a concentration tank, adding corresponding raw materials in order, stirring, completely dissolving, adding the activated carbon, stirring, filtering after stirring, and obtaining a concentration solution; (3) feeding to a dilution tank, adding the water for injection into the dilution tank until reaching to full dose, reflowing for stirring, then adjusting a ph value, and finally adding the water for injection until reaching the preparation amount; (4) detecting, filling and sterilizing the pharmaceutical solution. The injection prepared through the preparation method provided by the invention has a good treatment effect on hemiplegia and extremities dysfunctioncaused by cerebral apoplexy, and dysfunction and disturbance of consciousness caused by other central nervous system acute injury.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a citicoline injection pharmaceutical composition, its preparation method and application. Background technique [0002] Statistics show that as of the end of 2016, China's elderly population aged 60 and over exceeded 230 million, accounting for 16.7% of the total population; the elderly population aged 65 and above exceeded 150 million, accounting for 10.8% of the total population. It is estimated that by 2050, China's elderly population will reach 480 million, accounting for about two-fifths of the elderly population in Asia and one-quarter of the global elderly population, which is larger than the combined population of the United States, Britain, and Germany. The above data show that my country has entered an aging society ahead of schedule, and taking care of the elderly and allowing them to live a happy old age has become an important issue in our society. [0003] Amon...

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Problems solved by technology

[0003] Among them, the care of the elderly has become the most critical issue, because as the elderly grow older, their physical functions are gradually declining, and they are prone to various diseases such as high blood pressure, diabetes, heart disease and other chronic diseases; Structural changes are not limited to the elderly, but more and more young people are suffering from various diseases such as hyperglycemia, hyperlipidemia, and fatty liver. These diseases not only cause harm to human health, but more importantly, they cause Complications, some will lead to stroke, some will cause damage to organs, and some will cause serious damage to the nervous system of the human body, all of which seriously affect people's quality of life and cause heavy economic losses to individuals, families and society. burden, seriously affecting family happiness and social harmony

[0004] At the same time, because the elderly are older, their movements are slower, and their body reactions and coordination skills are also poorer. They will react more slowly than young people, fall easily, and easily cause various falls and bruises, the most serious of which is head injuries. Bruises can lead to acute trauma to the cranial brain, concussions in mild cases, and disturbance of consciousness and behavior, and craniocerebral injuries in severe cases, which can be life-threatening. Treatment of craniocerebral injuries is sometimes difficult to rely on drugs alone, and surgical treatment is often required. However, the operation is very technically difficult, and it is easy to cause postoperative sequelae. The more common ones are the disturbance of consciousness and physical behavior caused by the acute injury of the central nervous system; There are still few medicines and limb disorders, and citicoline is currently one of the main drugs for the treatment of consciousness and limb behavior disorders caused by acute central nervous injury after surgery, and has a good therapeutic effect, but the current citicoline The preparations of diphosphocholine drugs are mainly western medicine preparations, and less pharmaceutical preparations are used in combination with traditional Chinese medicine, which limits the improvement of its curative effect and the further exertion of its role

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