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Xingnaojing sustained release tablet and preparation method thereof

A technology of slow-release tablets and Xingnaojing, which is applied in the direction of pharmaceutical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc. Convenience and other issues, to achieve the effect of high acquisition rate, good fluidity and compressibility

Inactive Publication Date: 2018-09-18
WUXI JIYU SHANHE PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Injections are inconvenient to carry and use, and are only sold in hospitals, and cannot be purchased in retail pharmacies. Injections have a strong effect during first aid, but they cannot exert a sustained and stable drug effect for a long time after first aid. Therefore, now Developed a Xingnaojing sustained-release tablet, which is easy to carry, use, purchase and has a stable drug release rate

Method used

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  • Xingnaojing sustained release tablet and preparation method thereof
  • Xingnaojing sustained release tablet and preparation method thereof
  • Xingnaojing sustained release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] A preparation of Xingnaojing sustained-release tablets, the weight of the Xingnaojing sustained-release tablets is 0.5g. In this embodiment, the amount of raw materials containing Xingnaojing sustained-release tablets is calculated according to the amount of 2000 tablets. The Xingnaojing sustained-release tablets The raw materials and weight percentages of static slow-release tablets are: 50g of mixture, 650g of skeleton material, 200g of pregelatinized starch, 92g of microcrystalline cellulose, and 8g of magnesium stearate; the skeleton material is carbomer; For the preparation of static slow-release tablets, the mixture is pulverized according to the above weight percentage and passed through a 120 mesh sieve and then added to a three-dimensional motion mixer. Carbomer, pregelatinized starch, microcrystalline cellulose, and magnesium stearate are pulverized and passed through an 80 mesh After sieving, add a three-dimensional kinematic mixer; the rotating speed of the t...

Embodiment 2

[0071] A preparation of Xingnaojing sustained-release tablets, the weight of the Xingnaojing sustained-release tablets is 0.5g. In this embodiment, the amount of raw materials containing Xingnaojing sustained-release tablets is calculated according to the amount of 2000 tablets. The Xingnaojing sustained-release tablets The raw materials and weight percentages of static slow-release tablets are: mixture 60g, skeleton material 620g, pregelatinized starch 205g, microcrystalline cellulose 105g, magnesium stearate 10g; described skeleton material is carbomer; For the preparation of static slow-release tablets, the mixture is pulverized according to the above weight percentage and passed through a 120 mesh sieve and then added to a three-dimensional motion mixer. Carbomer, pregelatinized starch, microcrystalline cellulose, and magnesium stearate are pulverized and passed through an 80 mesh After sieving, add a three-dimensional kinematic mixer; the rotating speed of the three-dimens...

Embodiment 3

[0073] A preparation of Xingnaojing sustained-release tablets, the weight of the Xingnaojing sustained-release tablets is 0.5g. In this embodiment, the amount of raw materials containing Xingnaojing sustained-release tablets is calculated according to the amount of 2000 tablets. The Xingnaojing sustained-release tablets The raw materials and weight percentages of static slow-release tablets are: 70g of mixture, 590g of skeleton material, 215g of pregelatinized starch, 115g of microcrystalline cellulose, 10g of magnesium stearate; the skeleton material is carbomer; For the preparation of static slow-release tablets, the mixture is pulverized according to the above weight percentage and passed through a 120 mesh sieve and then added to a three-dimensional motion mixer. Carbomer, pregelatinized starch, microcrystalline cellulose, and magnesium stearate are pulverized and passed through an 80 mesh After sieving, add a three-dimensional kinematic mixer; the rotating speed of the thr...

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Abstract

The invention relates to a preparation method of a Xingnaojing sustained release tablet, comprising the following steps: (1) smashing fructus gardeniae, sifting, performing CO2 supercritical extraction to obtain a fructus gardeniae extract and a fructus gardeniae raffinate, including the fructus gardeniae extract with beta-cyclodextrin and smashing to obtain an inclusion complex 1; (2) smashing radix curcumae and sieving, performing CO2 supercritical extraction to obtain a radix curcumae extract and a radix curcumae raffinate, and including the radix curcumae extract with beta-cyclodextrin andsmashing to obtain an inclusion complex 2; (3) including borneol with beta-cyclodextrin and smashing to obtain an inclusion complex 3; (4) mixing the inclusion complex 1, the inclusion complex 2, theinclusion complex 3 and artificial musk according to a ratio to obtain a mixture; (5) taking the mixture as a pharmaceutically active ingredient, and adding a necessary auxiliary material for the sustained-release tablet to prepare the Xingnaojing sustained release tablet.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine sustained-release tablet, in particular to a preparation method of a Xingnaojing sustained-release tablet. Background technique [0002] Xingnaojing Injection is derived from the classic prescription - Angong Niuhuang Pills, and is refined through modern pharmaceutical technology. It is mainly used for apoplexy, coma, hemiplegia and oral cavity caused by qi and blood inversion, brain stasis; traumatic headache, coma; alcohol poisoning attacking the heart, headache, nausea, coma and convulsions. Cerebral embolism, acute cerebral hemorrhage, craniocerebral trauma, acute alcoholism see the above symptoms. [0003] Supercritical technology is more and more widely used in the extraction of traditional Chinese medicine. The main reason is that supercritical fluid technology has simple process, convenient operation, low energy consumption and material consumption, and more comple...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K47/32A61K47/36A61K47/34A61K47/12A61K47/69A61K36/9066A61P9/10A61P7/02A61P7/04A61P25/00A61P29/00A61P1/08A61P39/02A61K31/045A61K35/55
CPCA61K9/2027A61K9/2013A61K9/2054A61K9/2059A61K31/045A61K35/55A61K36/744A61K36/9066A61K47/6949A61K2236/39A61P1/08A61P7/02A61P7/04A61P9/10A61P25/00A61P29/00A61P39/02A61K2300/00
Inventor 华军樊小平於江华闵江蔡洁洁姚皆周宇蒋洁
Owner WUXI JIYU SHANHE PHARM CO LTD