Sleep-quality-improving composition prepared by virtue of biological method

A technology for improving sleep quality and composition, applied in the directions of drug combinations, medical preparations containing active ingredients, plant raw materials, etc. Improve sleep quality and good compatibility

Inactive Publication Date: 2018-09-21
杨俊杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Western medicines commonly used clinically to treat insomnia mainly include benzodiazepines, such as diazepam, nitrosepam, etc., barbiturates, such as phenobarbital, secobarbital, diphenylmethanes, such as Antaile, and others. Such as zolpidem, triazolam, zolpidone, etc.; although the curative effect is definite and quick, but there are also problems: first, taking western medicine is easy to produce dependence and drug resistance, so that the dose will increase The larger the dose, the easier it is to exceed the safe dosage range, and it is easy to produce serious adverse consequences if taken for a long time; secondly, western medicines are generally antibiotic drugs, which have certain toxicity, and long-term use will affect liver and kidney functions, and will cause many organ dysfunctions, disorders, Such as gastrointestinal dysfunction leading to nausea, loss of appetite, abdominal distension, constipation, dry mouth, bitter mouth, dry mouth and tongue, dizziness, vertigo and other symptoms after getting up in the morning;
[0004] Commonly used Chinese patent medicines for treating insomnia in clinical practice, such as Tianwang Buxin Pill, Niuhuang Qingxin Pill, Tongren Baizi Yangxin Pill, Anshen Buxin Pill, Zhusha Anshen Pill, etc. These medicines are generally aimed at a specific type of insomnia, such as Tianwang Buxin Dan is aimed at insomnia caused by yin deficiency and blood deficiency, while Niuhuang Qingxin Pill is aimed at insomnia caused by exuberant heart fire, etc. However, some people with sleep disorders are more difficult to be identified as the above-mentioned specific types
In addition, traditional Chinese medicine does not improve sleep quality significantly, and some effects are slow
[0005] In addition, there are still a small number of patients taking foreign imported medicines. Although the effect is remarkable, they are expensive and have a certain degree of dependence, so it is difficult to take them for a long time
In order to reduce the adverse reactions of drugs, many people with sleep disorders choose health products and expect to replace them. Although there are many brands of health products that improve sleep quality, it is difficult to achieve better results for drug substitutes that improve sleep quality

Method used

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  • Sleep-quality-improving composition prepared by virtue of biological method
  • Sleep-quality-improving composition prepared by virtue of biological method
  • Sleep-quality-improving composition prepared by virtue of biological method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A composition for improving sleep quality prepared by a biological method, comprising the following raw materials: 40kg of fermented centipede, 30kg of fermented Acanthopanax, 5kg of jujube extract and 3kg of glucuronic acid derivatives;

[0034] The fermented heartwood is prepared according to the following steps:

[0035] Crush the heartwood to 100-200 mesh, then add water and soak for 30 minutes to obtain the heartwood pulp, add cellulase to it, stir evenly, put it at a temperature of 30°C to ferment for 3 days, and then add sugar to it , Bacillus subtilis and Candida utilis were fermented at 35°C for 1 day to obtain a fermentation stock solution, adding distilled water to the fermentation stock solution, filtering, and freeze-drying the filtrate to obtain fermented fenugreek; wherein fencent wood, water, The mass ratio of cellulase, white sugar, Bacillus subtilis, Candida utilis and distilled water is 1:0.5:0.03:0.01:0.04:0.03:3; the activity of cellulase is 200U / g, B...

Embodiment 2

[0042] A composition for improving sleep quality prepared by a biological method, comprising the following raw materials: 50kg of fermented fenugreek, 40kg of fermented Acanthopanax, 10kg of jujube extract and 8kg of glucuronic acid derivatives;

[0043] The fermented heartwood is prepared according to the following steps:

[0044] Crush the heartwood to 100-200 mesh, then add water to soak for 45 minutes to obtain the heartwood pulp, add cellulase to it, stir it evenly, put it at a temperature of 40°C to ferment for 5 days, and then add sugar to it , Bacillus subtilis and Candida utilis were fermented at 50°C for 2 days to obtain a fermented stock solution, adding distilled water to the fermented stock solution, filtering, and lyophilizing the filtrate to obtain fermented fenugreek; wherein fencented wood, water, The mass ratio of cellulase, white sugar, Bacillus subtilis, Candida utilis and distilled water is 1:1:0.06:0.05:0.08:0.06:6; the activity of cellulase is 500U / g, Ba...

Embodiment 3

[0051] A composition for improving sleep quality prepared by a biological method, comprising the following raw materials: 42kg of fermented centipede, 34kg of fermented Acanthopanax, 8kg of jujube extract and 6kg of glucuronic acid derivatives;

[0052] The fermented heartwood is prepared according to the following steps:

[0053] Crush the heartwood to 100-200 mesh, then add water to soak for 40 minutes to obtain the heartwood pulp, add cellulase to it, stir evenly, put it at a temperature of 35°C to ferment for 4 days, and then add sugar to it , Bacillus subtilis and Candida utilis were fermented at 40° C. for 1.5 days to obtain a fermentation stock solution, adding distilled water to the fermentation stock solution, filtering, and lyophilizing the filtrate to obtain fermented fenugreek; wherein fencent wood, water, The mass ratio of cellulase, white sugar, Bacillus subtilis, Candida utilis and distilled water is 1:0.6:0.04:0.02:0.05:0.04:4; the activity of cellulase is 300U...

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Abstract

The invention discloses a sleep-quality-improving composition prepared by virtue of a biological method. The composition contains the following raw materials: fermented diaphragma juglandis, fermentedacanthopanax root, a Chinese date extract and a glucuronic acid derivative. By virtue of reasonable compatibility of the components, the composition has a very good synergistic interaction effect, has efficacies of tonifying spleen-stomach, replenishing vital energy, nourishing blood, calming nerves, helping sleeping, invigorating stomach, eliminating liver fire and dredging lungs, has good actions and effects on the improvement of sleeping and relieving of mood and is specific in taste and high in safety and capable of improving the sleep; the composition has no toxic or side effect, does not generate dependence and can be eaten for a long time; and the composition is capable of obviously improving the sleep quality, a sleep-quality-improving effect basically similar to Western medicinescan be achieved, and the symptom does not relapse after drug withdrawal.

Description

technical field [0001] The invention relates to the technical field of biological fermentation, and relates to a composition for improving sleep quality prepared by a biological method. Background technique [0002] Insomnia is the most common clinical sleep disorder type, long-term insomnia will have a serious negative impact on people's normal life and work, and even lead to malignant accidents. Insomnia belongs to the category of insomnia and insomnia in traditional Chinese medicine. It mainly occurs due to evil disturbance of the mind or lack of nourishment of the mind, resulting in yang not communicating with yin or mind not keeping the house. Another theory holds that the pathogenesis of insomnia is mostly caused by wet food producing phlegm, stagnant phlegm generating heat and disturbing the mind. [0003] Western medicines commonly used clinically to treat insomnia mainly include benzodiazepines, such as diazepam, nitrosepam, etc., barbiturates, such as phenobarbita...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61P25/20A61K31/7012
CPCA61K31/7012A61K36/254A61K36/52A61K36/725A61K2236/19A61P25/20A61K2300/00
Inventor 杨俊杰张磊
Owner 杨俊杰
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